CAS: 58917-85-4; Cbz-D-Phenylalaninol

上下游产品

CAS号5267-64-1 D-苯丙氨醇 | CAS号501-53-1 氯甲酸苄酯 | CAS号2448-45-5 N-CBZ-D-苯丙氨酸 | CAS号1885-14-9 氯甲酸苯酯 | CAS号13139-17-8 苯甲氧羰酰琥珀酰亚胺 | CAS号41518-17-6 (S)-(S)-2-(((be... | CAS号37440-07-6 methyl (2R)-3-p... | CAS号63219-70-5 N-cbz-d-苯丙氨醛 | CAS号58970-76-6 乌苯美司 | CAS号153244-86-1 (4R,5S,6S,7R)-4... | CAS号153223-21-3 (4R,5S,6S,7R)-4... | CAS号153223-23-5 (4R,5S,6S,7R)-1... | CAS号151867-81-1 (4R,5S,6S,7R)-4...

N-苄氧羰基-D-苯丙氨酸置于硼烷体系中,用 四氢呋喃 作为反应溶剂,以84%的收率获得产物cbz-D-苯丙氨醇
参考文献:通过passerini反应有效构建α-羟基-β-氨基酰胺的新合成技术.
标题:通过passerini反应有效构建α-羟基-β-氨基酰胺的新合成技术.
摘要:[反应:见正文]使用吡啶型碱的n-保护的氨基醛,异腈和tfa的passerini反应在温和的条件下进行,并以中等至高收率直接提供α-羟基-β-氨基酰胺衍生物.这些加合物容易水解成α-羟基-β-氨基羧酸.说明了这些关键中间体在简明p(1)-α-酮酰胺蛋白酶抑制剂合成中的应用.
DOI:10.1021/ol0061485

专利信息

专利号:US-5157143-A
优先权日:1988-05-11
标题 :Diastereoselective process for the preparation of intermediates useful for the synthesis of peptide derivatives
发明人：PELLACINI FRANCO; CHIARINO DARIO; CARENZI ANGELO
权利人:ZAMBON SPA
摘要:A diastereoselective process for the preparation of compounds of formula ##STR1## (wherein R and R 1 have the meanings reported in the specification and the asterisks show the asymmetric carbon atoms) starting from the corresponding N-protected 2-amino-3-aryl-propan-1-ol is described. n The compounds of formula I are intermediates useful for the synthesis of pharmacologically active peptides.

专利号:US-5530124-A
优先权日:1994-06-30
标 题:Method for preparing cyclic ureas and their use for the synthesis of HIV protease inhibitors
发明人：RADESCA LILIAN A; HARRIS GREGORY D; WAT EDWARD K W; WALTERMIRE ROBERT E
权利人:DU PONT MERCK PHARMA
摘要:This invention provides improved synthetic processes for the preparation of hydroxy-protected cyclic urea compounds of Formula (IX), ##STR1## which are useful as intermediates for the preparation of cyclic urea human immunodeficiency virus (HIV) protease inhibitors, from N-protected aminoaldehydes. The processes of the present invention provide high yields, can be conducted on multikilogram scale, and eliminate the need for chromatographic purification of intermediates or final product.

专利号:EP-0341462-A1
优先权日:1988-05-11
标题 :Diastereoselective process for the preparation of intermediates useful for the synthesis of peptide derivatives

专利号:EP-0341462-B1
优先权日:1988-05-11
标题 :Diastereoselective process for the preparation of intermediates useful for the synthesis of peptide derivatives

专利号:DE-68902771-T2
优先权日:1988-05-11
标题 :DIASTEREOSELECTIVE METHOD FOR THE PRODUCTION OF INTERMEDIATE PRODUCTS USED FOR THE PEPTIDE DERIVATIVE SYNTHESIS.