CAS: 67467-83-8; 2,6-Dimethyl-4-(2-Methyl-3-(4-(Tert-Pentyl)Phenyl)Propyl)Morpholine

上下游产品

Bepromoline Hcl
1-(2-甲基-3-苯基丙基)哌啶 N-(2-Methyl-3-Phenylpropyl)Piperidine 74879-98-4
1-(2-Methyl-3-Phenyl-Propyl)-3,5-Dimethyl-Piperidine

Bepromoline Hcl,2-氯代-2-甲基丁烷置于iron(Iii) Chloride 盐酸,Sodium Hydroxide,Sodium Phosphate体系中,用 二氯甲烷,水 作为反应溶剂,化学反应 2.5H,反应生成 阿莫罗芬
参考文献:Process Of Producing Bepromoline
标题:Process Of Producing Bepromoline
摘要:本发明涉及一种制造公式(Ia)化合物的过程:所述过程包括:(I)在钯催化剂,甲醇和氢气的存在下,将公式(Iii)化合物与公式(Iv)化合物接触,所述步骤(I)最好在碱性条件下进行,一旦氢气的消耗停止,加入乙酸.

专利信息

专利号:US-2009131660-A1
优先权日:2006-04-03
标 题 :SYNTHESIS OF 3-[4-(1,1-DIMETHYL-PROPYL)-PHENYL]-2-METHYL-PROPIONALDEHYDE AND cis-4--2,6-DIMETHYL-MORPHOLINE (AMOROLFINE)
发明人：BOITEAU JEAN-GUY; MUSICKI BRANISLAV
权利人:GALDERMA SA
摘要:3-[4-(1,1-Dimethyl-propyl)-phenyl]-2-methyl-propionaldehyde and cis-4-{3-[4-(1,1-dimethyl-propyl)-phenyl]-2-methyl-propyl}-2,6-dimethyl-morpholine (Amorolfine) are synthesized, first by Heck reacting a compound of general formula (VI): n n n n n n n n n n with 2-methyl-prop-2-en-1-ol of formula (VII): n n n n n n n n n n in the presence of a palladium catalyst and a base, in a solvent selected from among N,N-dimethylformamide, polar protic and non-polar organic solvents, and at a temperature ranging from 60° C. to 150° C., and then conducting an amino reduction by reacting the 3-[4-(1,1-dimethyl-propyl)-phenyl]-2-methyl-propionaldehyde of formula (II) with cis-2,6-dimethyl morpholine of formula (IV): n n n n n n n n n n in the presence of a reducing agent and in a solvent.

专利号:EP-0008686-B1
优先权日:1978-08-08
标 题 :Synthesis of phenyl-propyl morpholine and piperidine derivatives

专利号:EP-0008686-A2
优先权日:1978-08-08
标题:Synthesis of phenyl-propyl morpholine and piperidine derivatives