CAS: 72402-14-3; ((3Ar,4R,6Ar)-6-Methoxy-2,2-Dimethyltetrahydrofuro[3,4-D][1,3]Dioxol-4-yl)Methanol

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4099-85-8 4099-88-1 4137-56-8

上下游产品

methanol D-Ribose 2,2-dimethoxy-propane acetone4-Benzoyl-1-(2,3-O-isopropylidene-α-D-ribofuranosyl)-cytosineN4-Benzoyl-1-(2,3-O-isopropylidene-α-D-ribofuranosyl)-cytosine 4-N-benzoyl-2',3'-O-isopropylidenecytidine 1-O-methyl-5-O-benzyl-2,3-O-isopropylidene-D-ribofuranoside 5-O-benzoyl-2,3-isopropylidene-1-methoxy-D-ribofuranoside

卡培他滨杂质25置于硫酸体系中,化学反应 12.83H,反应生成 甲基-2,3-O-异亚丙基-D-呋喃核糖苷
参考文献:一种l-来苏糖的制备工艺
标题:一种l-来苏糖的制备工艺
摘要:本发明属于l‑来苏糖制备技术领域,具体涉及一种l‑来苏糖的制备工艺,包括1‑甲基‑d‑核糖的合成,2,3‑丙叉‑甲基‑d‑核糖的合成,2,3‑丙叉‑甲磺酰基‑甲基‑d‑核糖的合成,2,3‑丙叉‑甲基‑l‑来苏糖和l‑来苏糖的合成.本发明公开的一种l‑来苏糖的制备工艺以d‑核糖为原料,经过上甲基,上丙叉,上保护基(甲磺酰酯),转换脱保护,D变l,脱甲基脱丙叉合成l‑来苏糖.整个制备工艺转化效率高,工艺相对简单,原料廉价易得,操作简便,安全,所得产物纯度高.

专利信息

专利号:EP-2666771-A1
优先权日:2012-05-24
标题 :Synthesis of Aminocyclopentanetriol Derivatives
发明人：STERK DAMJAN; CASAR ZDENKO
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific intermediates suitable for the preparation of triazolopyrimidine compounds such as ticagrelor. nThe present invention provides in particular a process for the preparation of a compound of formula Vn ncomprising: na) providing a compound of formula IVn n, and nb) reducing the compound of formula IV with activated zinc in the presence of copper to give the compound of formula V.

专利号:US-9278972-B2
优先权日:2011-12-23
标题 :Synthesis of triazolopyrimidine compounds
发明人：MARAS NENAD; GAZIC SMILOVIC IVANA; STERK DAMJAN
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific intermediates suitable for the preparation of triazolopyrimidine compounds such as ticagrelor.

专利号:US-6765091-B1
优先权日:1999-08-30
标题:Oligosaccharides derived from ribose-ribitol-phosphate, and vaccines containing them
发明人：BENCOMO VICENTE GUILLERMO VERE; ROY RENE
权利人:UNIV LA HABANA; UNIV OTTAWA
摘要:The present invention relates to the field of the Medicine, in particular with the chemical synthesis of oligosaccharide mixtures derived of ribose-ribitol-phosphate, which are used as active principle in vaccines for the prevention of infections caused by Haemophilus influenzae type b (Hib), as well as with the vaccines containing said oligosaccharide mixtures. n The oligasaccharide mixtures obtained by chemical synthesis of the present invention, comprise repeating units of formulae (phosphate-ribosa-ribitol)n or (ribose-ribitol-phosphate)n of at least 5 compounds of structure A or B, which represent the repeating unit of the capsular polysaccharide of Haemophilus influenzae type b and differ only by n, being n a value contained between 4 and 25 (n≧4 y≦25), and wherein R 1 or R 2 is a spacer for conjugation to a carrier, with the condition of R 1 =spacer if R 2 =H, or R 2 =spacer if R 1 =H. n The invention also is related with the immunogens containing such oligosaccharide mixtures, with the vaccines containing said immunogens and with the methods to prepare these oligosaccharides as mixtures. Furthermore, the invention includes the use of the vaccines, alone or combined with other vaccines, for the prevention of the infections caused by Haemophilus influenzae type b.

专利号:US-2014371449-A1
优先权日:2011-12-23
标题 :Synthesis of Triazolopyrimidine Compounds

专利号:EP-2794575-A1
优先权日:2011-12-23
标题 :Synthesis of triazolopyrimidine compounds

专利号:EP-2794575-B1
优先权日:2011-12-23
标题 :Synthesis of triazolopyrimidine compounds