CAS: 74115-12-1; 5-Chloro-3-Hydroxypyridine

相似化合物

95881-83-7 110860-92-9 209328-72-3

上下游产品

5-chloro-2-methoxypyridine 3,5-dichloropyridine furan-2-ylmethanamine 4-methyl-2-pentanone Phosphoric acid dibenzyl ester 5-chloro-pyridin-3-yl ester 2,5-Dichloro-3-hydroxypyridine 2,5,6-Trichloro-3-hydroxypyridine 5.6-Dichloro-3-hydroxypyridine

3,5-二氯吡啶置于sodium Methylate,Mesna体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 6.0H,反应生成 5-氯-3-羟基吡啶
参考文献:一些卤代吡啶与甲醇盐和甲硫醇盐离子在二甲基甲酰胺中的反应
标题:一些卤代吡啶与甲醇盐和甲硫醇盐离子在二甲基甲酰胺中的反应
摘要:2,6-和2,5-二溴吡啶和2,3-和3,5-二氯吡啶与异丙硫醇钠和甲硫醇钠的反应根据实验条件提供单取代或双取代的产物.相同的吡啶与甲醇钠反应,得到非常好收率的单取代产物.仅在2,6-二溴-和3,5-二氯吡啶中容易发生双取代.还描述了从卤代甲氧基吡啶或卤代硫代甲氧基吡啶开始的一些甲氧基硫代甲氧基吡啶的合成.双(烷硫基)吡啶可被hmpa中的钠裂解,得到双(巯基)吡啶.
DOI:10.1016/s0040-4020(01)96539-1

专利信息

专利号:US-4756739-A
优先权日:1985-12-21
标题 :Pyridine derivatives and the N-oxides thereof, and the use thereof as intermediates for the synthesis of plant protecting agents
发明人：FUSS ANDREAS; KOCH VOLKER
权利人:HOECHST AG
摘要:The compounds of the formula I (I) in which A denotes N or N->O, Z denotes O or NH, R denotes H, (halo)alkyl, (halo)alkenyl, (halo)alkynyl or alkoxycarbonyl, R1 denotes hydrogen, halogen, amino, -NHOH, hydroxyl, (substituted) phenylazo or a radical of the formulae Y=C=N-, Y1Y2C=N-, Y3NH- or K denotes 0 or 1, and m and n, independently of one another, denote a number from 1 to 4, with the proviso that, when Z-R denotes OH or NH2, (R1)n denotes at least one radical of the formula or represents two radicals, in the 5 or 6 position of the heterocyclic ring, which, in the 5 position, denote halogen and, in the 6 position, denote a radical of the group comprising halogen, amino, hydroxyl or phenylazo, which may be substituted as specified above, are valuable intermediates in the synthesis of plant protection agents.

专利号:US-7816375-B2
优先权日:2000-09-11
标 题 :Ligands for monoamine receptors and transporters, and methods of use thereof
发明人：AQUILA BRIAN M; BANNISTER THOMAS D; CUNY GREGORY D; HAUSKE JAMES R; HOLLAND JOANNE M; PERSONS PAUL E; RADEKE HEIKE; WANG FENGJIANG; SHAO LIMING
权利人:SEPRACOR INC
摘要:One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian cellular receptors, including dopamine, serotonin, or norepinephrine transporters. The compounds of the present invention will find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to addiction, anxiety, depression, sexual dysfunction, hypertension, migraine, Alzheimer's disease, obesity, emesis, psychosis, schizophrenia, Parkinson's disease, inflammatory pain, neuropathic pain, Lesche-Nyhane disease, Wilson's disease, and Tourette's syndrome. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the heterocyclic compounds, and the screening of those libraries for biological activity, e.g., in assays based on dopamine transporters.

专利号:WO-2008028776-A1
优先权日:2006-09-06
标题 :Agents containing bioquinones and specific emulsifiers
发明人：SCHULZE ZUR WIESCHE ERIK; SCHEUNEMANN VOLKER; POPPE ELISABETH; WELSS THOMAS; GIESEN MELANIE
权利人:HENKEL KGAA; SCHULZE ZUR WIESCHE ERIK; SCHEUNEMANN VOLKER; POPPE ELISABETH; WELSS THOMAS; GIESEN MELANIE
摘要:The invention relates to cosmetic agents, in particular hair treatment agents, containing at least one specific emulsifier and at least one bioquinone. Treating the hair with said agents activates the keratin synthesis of hair keratin that declines with age.

专利号:WO-0056709-A1
优先权日:1999-03-24
标 题:Indolinone compounds as kinase inhibitors
发明人：TANG PENG CHO; SUN LI; MCMAHON GERALD; MILLER TODD ANTHONY; SHIRAZIAN SHAHRZAD; WEI CHUNG CHEN; HARRIS G DAVIS; XIAOYUAN LI; LIANG CONGXIN
权利人:SUGEN INC; TANG PENG CHO; SUN LI; MCMAHON GERALD; MILLER TODD ANTHONY; SHIRAZIAN SHAHRZAD; WEI CHUNG CHEN; HARRIS G DAVIS; XIAOYUAN LI; LIANG CONGXIN
摘要:The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds of the invention. The invention also relates to methods of modulating the function of protein kinases using indolinone compounds of the invention and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.

专利号:US-6689806-B1
优先权日:1999-03-24
标 题 :Indolinone compounds as kinase inhibitors
发明人：TANG PENG CHO; SUN LI; MCMAHON GERALD; MILLER TODD ANTHONY; SHIRAZIAN SHAHRZAD; WEI CHUNG CHEN; HARRIS JR G DAVIS; LI XIAOYUAN; LIANG CONGXIN
权利人:SUGEN INC
摘要:The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds of the invention. The invention also relates to methods of modulating the function of protein kinases using indolinone compounds of the invention and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.

专利号:CN-111233931-B
优先权日:2020-03-26
标题:Synthesis method of Reidesciclovir