CAS: 76513-69-4; 2-(Trimethylsilyl)Ethoxymethyl Chloride

上下游产品

formaldehyd 2-(Trimethylsilyl)ethanol chloro-trimethyl-silane 1-bromo-2-(chloromethoxy)ethane 1-[(2-(trimethylsilyl)ethoxy)methyl]-1H-pyrazole 1-(2-Trimethylsilylethoxymethyl)-1H-benzoimidazole Phenyl-acetic acid 2-trimethylsilanyl-ethoxymethyl ester methyl>-2-phenylimidazole3-2-(trimethylsilyl)ethoxymethyl-2-phenylimidazole

三甲基氯硅烷,1-溴-2-氯甲氧基-乙烷置于正丁基锂,甲基氯化镁体系中,用 四氢呋喃,正己烷 作为反应溶剂,化学反应 0.66H,以85.8%的收率获得产物2-(三甲基硅烷基)乙氧甲基氯
参考文献:一种抗骨髓纤维化鲁索利替尼的重要中间体sem-Cl的简便合成方法
标题:一种抗骨髓纤维化鲁索利替尼的重要中间体sem-Cl的简便合成方法
摘要:本发明公开了一种抗骨髓纤维化鲁索利替尼的重要中间体sem‑cl的简便合成方法,以2‑溴乙醇为主原料,以石油醚作为反应溶剂,多聚甲醛和氯化氢为氯甲基化试剂,浓硫酸为吸水剂,合成氯甲基化中间体;再以格氏试剂和丁基锂的配合物为碱拔溴,和三甲基氯硅烷反应,两步合成目标产物,原材料简单易得,成本低,操作简单方便,收率高,三废少,工艺合理,质量稳定.

专利信息

专利号:US-2020079715-A1
优先权日:2018-09-06
标题 :2-position modification for synthesis of resorcinol scaffolding
发明人：DAVIS ROBERT; BLACK JACOB; SMELTZER THOMAS; COLVIN SEAN
权利人:CANOPY HOLDINGS LLC
摘要:A resorcinol with modifications at the 2-position is provided. The reactant resorcinol may have a variety of functional groups at each of the 1, 3, and 5 position such as a hydroxide, a lower alkyl group, a phenyl, a substituted phenyl, a lower alkenyl, or a lower alkynyl sp 2 carbon group (e.g., substituted phenyl, vinyl), sp (e.g., alkyne), hydrogen. The resorcinol is modified at the 2-position with a nucleophile or an electrophile. The resulting resorcinol may serve as a stable intermediate for the synthesis of cannabinoid or cannabinoid derivatives.

专利号:US-2025236633-A1
优先权日:2022-03-28
标 题:Synthesis of isomerically pure polyol-based phosphoramidites
发明人：BANASIK BRENT; DIAZ CORRAL JULIAN ANDRES; JACOBS AARON; JUD LUKAS; KUCHELMEISTER HANNES; NBAVI MELUD; PFAFFENEDER TONI; SIMONYIOVA SONA; TABONE JOHN C; THUER WILMA
权利人:ROCHE SEQUENCING SOLUTIONS INC
摘要:The present disclosure relates to a process for the regiochemically and enantiomerically controlled synthesis of phosphoramidite-containing monomers, and to intermediate products of this process. In some embodiments, the phosphoramidite-containing monomers or their precursors are regioisomerically and/or enantiomerically pure and may be polymerized into polymers or copolymers.

专利号:US-2013012706-A1
优先权日:2010-03-01
标 题 :Methods and Intermediates for the Synthesis of 4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazines
发明人：HUMMERSONE MARC GEOFFERY; COUSIN DAVID
权利人:PHARMINOX LTD; HUMMERSONE MARC GEOFFERY; COUSIN DAVID
摘要:The present invention provides a compound of general formula (II), or a salt or solvate thereof: n n n n n n n n n n n n wherein n A is independently -A 1 , -A 2 , -A 3 , -A 4 , -A 5 , -A 6 , or -A 7 , wherein:n -A 1 is independently C 5-12 heteroaryl, and is optionally substituted; -A 2 is independently thioamido or substituted thioamido; -A 3 is independently imidamido, substituted imidamido, N-hydroxyimidamido, or substituted N-hydroxyimidamido; -A 4 is independently hydroxamic acid or hydroxamate; -A 5 is independently carboxamide or substituted carboxamide; -A 6 is independently aliphatic C 2-6 alkenyl, and is optionally substituted; and -A 7 is independently carboxy or C 1-4 alkyl-carboxylate;n nand its use in the synthesis of temozolomide and analogues thereof.

专利号:US-2025091989-A1
优先权日:2023-09-19
标 题 :Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:WO-2022238500-A1
优先权日:2021-05-12
标题 :Radiosynthesis of [18f] talazoparib
发明人：BOWDEN GREGORY DAVID; MAURER ANDREAS; STOTZ SOPHIE; KINZLER PAUL JOHANNES OSKAR MARIA; LAEMMERHOFER MICHAEL; ZENDER LARS; PICHLER BERND
权利人:UNIV TUEBINGEN MEDIZINISCHE FAKULTAET
摘要:The present invention relates to the synthesis of Poly (ADP ribose) polymerase (PARP) inhibitors and particularly to the radiosynthesis of PARP 1 inhibitors, more particularly to the synthesis of [18F] talazoparib.

专利号:US-2025197439-A1
优先权日:2022-03-18
标 题:Decarboxylative acetoxylation using mn(ii) or mn(iii) reagent for synthesis of 4'-acetoxy-nucleoside and use thereof for synthesis of corresponding 4'-(dimethoxyphosphoryl)methoxy-nucleotide
发明人：VAGLE KURT EDRIC; BHADURI SAYANTAN; YANG GUOHAN
权利人:DICERNA PHARMACEUTICALS INC
摘要:The present invention relates to the preparation of nucleic acids, nucleosides, nucleotides, and analogues thereof useful as potent and stable RNA interference agents. The present invention provides improved yields and avoids the use of lead tetraacetate for decarboxylative acetylation which decreases the overall cost of production by removing the need for lead remediation and offers a significant reduction in the environmental costs in production.