CAS: 116574-71-1; Tert-Butyl 3-(Hydroxymethyl)Piperidine-1-Carboxylate

相似化合物

140695-84-7 140695-85-8 39945-51-2

上下游产品

CAS号4606-65-9 3-哌啶甲醇 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号148763-41-1 N-B°C-3-哌啶甲酸甲酯 | CAS号121-44-8 三乙胺 | CAS号68-22-4 炔诺酮 | CAS号71962-74-8 呱啶乙酯 | CAS号205194-11-2 (R)-(1-甲基哌啶-3-基)甲醇 | CAS号194726-46-0 (R)-3-甲酰基哌啶-1-甲酸叔丁酯 | CAS号191092-07-6 (R)-3-(甲苯磺酰氧基甲基... | CAS号191092-05-4 3-(甲苯磺酰氧基甲基)哌啶-... | CAS号876589-09-2 3-(氯甲基)-1-哌啶甲酸叔丁酯 | CAS号155541-67-6 (R)-tert-butyl ... | CAS号116574-71-1 1-B°C-3-羟甲基哌啶 | CAS号140695-84-7 (S)-1-B°C-3-羟甲基哌啶 | CAS号118156-93-7 1-B°C-3-哌啶甲醛

N-Boc-3-哌啶甲酸甲酯置于lithium Aluminium Tetrahydride,Glauber'S Salt体系中,用 四氢呋喃 用作溶剂,化学反应 2.0H,以99%的收率获得1-Boc-3-羟甲基哌啶
参考文献:2-Substituted-Ethynylthiazole Derivatives And Uses Of Same
标题:2-Substituted-Ethynylthiazole Derivatives And Uses Of Same
摘要:本发明提供了公式(i)的2-取代-乙炔基噻唑衍生物:其中r1,R2和x如此处定义,或其药学上可接受的盐;以及使用相同的药物组合物和方法.

专利信息

专利号:US-7816375-B2
优先权日:2000-09-11
标 题 :Ligands for monoamine receptors and transporters, and methods of use thereof
发明人：AQUILA BRIAN M; BANNISTER THOMAS D; CUNY GREGORY D; HAUSKE JAMES R; HOLLAND JOANNE M; PERSONS PAUL E; RADEKE HEIKE; WANG FENGJIANG; SHAO LIMING
权利人:SEPRACOR INC
摘要:One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian cellular receptors, including dopamine, serotonin, or norepinephrine transporters. The compounds of the present invention will find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to addiction, anxiety, depression, sexual dysfunction, hypertension, migraine, Alzheimer's disease, obesity, emesis, psychosis, schizophrenia, Parkinson's disease, inflammatory pain, neuropathic pain, Lesche-Nyhane disease, Wilson's disease, and Tourette's syndrome. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the heterocyclic compounds, and the screening of those libraries for biological activity, e.g., in assays based on dopamine transporters.

专利号:US-6872716-B2
优先权日:2000-09-11
标题:Antipsychotic sulfonamide-heterocycles, and methods of use thereof
发明人：WU XINHE; AQUILA BRIAN M; SHAO LIMING; RADEKE HEIKE; CUNY GREGORY D; HAUSKE JAMES R; XIE ROGER L
权利人:SEPRACOR INC
摘要:One aspect of the present invention relates to heterocyclic compounds comprising a sulfonamide moiety. A second aspect of the present invention relates to the use of the heterocyclic compounds comprising a sulfonamide moiety to treat diseases, afflictions or maladies caused at least in part by abnormal activity of one or more GPCRs or ligand-gated ion channels. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the heterocyclic compounds comprising a sulfonamide moiety, and the screening of those libraries for biological activity, e.g., in animal models of psychosis.

专利号:US-2012115907-A1
优先权日:2009-04-24
标题 :Novel compounds as inhibitors of renin
发明人：THOMBARE PRAVAIN; DESAI JIGAR; JAIN MUKUL R
权利人:THOMBARE PRAVAIN; DESAI JIGAR; JAIN MUKUL R; CADILA HEALTHCARE LTD
摘要:The present invention relates to novel renin inhibitors of general formula (1), novel intermediates involved in their synthesis, their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present invention also relates to a process of preparing compounds of general formula (1), their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.

专利号:US-7511141-B2
优先权日:2001-03-02
标题 :Piperidine-piperazine ligands for neurotransmitter receptors
发明人：PERSONS PAUL E; RADEKE HEIKE
权利人:SEPRACOR INC
摘要:One aspect of the present invention relates to piperidine-piperazine compounds. A second aspect of the present invention relates to the use of the piperidine-piperazine compounds as ligands for various mammalian cellular receptors or transporters or both, including dopamine, serotonin or norepinephrine receptors or transporters, any combination of them, or all of them. The compounds of the present invention will find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to addiction, anxiety, depression, sexual dysfunction, hypertension, migraine, Alzheimer's disease, obesity, emesis, psychosis, analgesia, schizophrenia, Parkinson's disease, restless leg syndrome, sleeping disorders, attention deficit hyperactivity disorder, irritable bowel syndrome, premature ejaculation, menstrual dysphoria syndrome, urinary incontinence, inflammatory pain, neuropathic pain, Lesche-Nyhane disease, Wilson's disease, and Tourette's syndrome. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the piperidine-piperazine compounds, and the screening of those libraries for biological activity, e.g., in assays based on dopamine receptors or transporters or both.

专利号:US-9861636-B2
优先权日:2014-04-29
标题 :Polyfluorinated compounds acting as bruton tyrosine kinase inhibitors
发明人：HE WEI
权利人:HE WEI; ZHEJIANG DTRM BIOPHARMA CO LTD
摘要:Described herein is a novel series of multi-fluoro-substituted pyrazolopyrimidine compounds or salts thereof. These compounds are Bruton's tyrosine kinase (BTK) inhibitors. These compounds may possess better BTK inhibition selectivity and pharmacokinetic properties. Disclosed herein are the synthesis methods of these compounds. Disclosed herein are novel synthesis methods of the multi-fluoro-substituted benzophenone and substituted phenoxy benzene. Also disclosed are pharmaceutical compositions comprising the BTK inhibitors described herein. The present invention also relates to pharmaceutical formulations comprising the compounds described herein as active ingredients. The present invention also includes the therapeutic methods by administering the BTK inhibitors and their formulations to treat and inhibit autoimmune disease, hypersensitivity disease, inflammatory diseases and cancer.

专利号:WO-2025026392-A1
优先权日:2023-08-02
标题 :Kinesin kif18a inhibitor and use thereof
发明人：XIAO YISONG; LAI KUNMIN; GU XIAOHUI; WANG MINGHUA; DENG JIACHEN; HU MIN
权利人:SHANGHAI APEIRON THERAPEUTICS COMPANY LTD
摘要:A KIF18 inhibitor having a structure as shown in formula (I) and a synthesis method therefor. The compound can be used to adjust the KIF18A protein, thereby affecting a cell cycle and cell proliferation process for the treatment of cancer and cancer-related diseases. Further disclosed are a pharmaceutical composition containing the compound, and a method for the treatment of conditions associated with KIF18A activity.