CAS: 130931-83-8; (1S,4R)-2-Azabicyclo[2.2.1]Hept-5-En-3-One

相似化合物

79200-56-9 49805-30-3 162427-15-8

上下游产品

2-氮杂双环[2.2.1]庚-5-烯-3-酮 2-Azabicyclo[2.2.1.]Hept-5-En-3-One 49805-30-3
(-)-文斯内酯 (-)-2-Azabicyclo[2.2.1]Hept-5-En-3-One 79200-56-9
2-羟甲基-2-氮杂双环[2.2.1]庚-5-烯-3-酮 2-Hydroxymethyl-2-Azabicyclo<2.2.1>Hept-5-En-3-One 157732-10-0
Racemic N-Hydroxymethyl Vince Lactam

Cis-1,2,3,6-Tetrahydrophthalic Anhydride置于sodium Tetrahydroborate,Camphor-10-Sulfonic Acid,(4R,5R)-2,2-二甲基-A,A,A',A'-四苯基-1,3-二氧戊环-4,5-二甲醇体系中,用 二氯甲烷 用作溶剂,化学反应 14.0H,反应生成(1S)-(+)-2-氮杂双环[2.2.1]庚-5-烯-3-酮
参考文献:的非还原对映体选择性开环ñ-二异丙与α,α,α',α'-四芳基-1,3-二氧戊环-4,5-Dimethanolate(甲基磺酰基)二甲
标题:的非还原对映体选择性开环ñ-二异丙与α,α,α',α'-四芳基-1,3-二氧戊环-4,5-Dimethanolate(甲基磺酰基)二甲
摘要:二环丙氧基钛taddolate将双环和三环内消旋-N-(甲基磺酰基)二甲酰亚胺1A-F对映体转化为异丙基[(磺酰胺基)羰基]-羧酸盐2A-F(产率为75-92%;参见方案3).产物的对映体比例在86:14至97:3之间,并且从ch 2 Cl 2 /己烷中重结晶得到对映体纯的磺酰胺基酯2(方案3).对映选择性与所用taddol的对映体过量显示线性关系(图3).还原酯基和羧酰胺基(lialh 4)和酰亚胺开环的产物2中磺酰胺基(red-Al)的额外还原裂解分别得到羟基磺酰胺3和氨基醇4(流程4).磺酰胺基酯2的绝对构型是通过化学相关性(与2A,B;方案6),对3E的樟脑酸酯的x射线分析(图1)以及对羟基苯甲酸酯的19 F-NMR分析确定的羟基磺酰胺3的较硬酯(表1).对于伯醇和胺的的绝对构型的分配的一般建议式hxch 2 Chr 1-[r 2,X = O,Nh,建议(见11在表1中).从2
Doi:10.1002/hlca.19960790328

专利信息

专利号:US-9334273-B1
优先权日:2014-03-05
标题:Efficient and stereoselective synthesis of 2′-fluoro-6′-methylene-carbocyclic adenosine (FMCA)
发明人：CHU DAVID C K; SINGH UMA S
权利人:UNIV GEORGIA
摘要:The invention provides a new convergent approach for the synthesis of 2′-fluoro-6′-methylene-carbocyclic adenosine (FMCA) from a readily available starting material (Vince lactam) in fourteen steps. An efficient and practical methodology for stereospecific preparation of a versatile carbocyclic key intermediate, D -2′-fluoro-6′-methylene cyclopentanol by diazotization, elimination, stereoselective epoxidation, fluorination and oxidative reduction of the Vince lactam in twelve steps is also provided.

专利号:US-2010204463-A1
优先权日:2007-08-07
标题 :Preparation Of Synthetic Nucleosides via Pi-Allyl Transition Metal Complex Formation
发明人：LIOTTA DENNIS C; LI YONGFENG
权利人:LIOTTA DENNIS C; LI YONGFENG
摘要:This invention provides highly regioselective and stereoselective processes for preparing synthetic nucleosides. A process for the preparation of synthetic nucleosides is provided that comprises a) preparing a bicycloamide derivative, b) reacting the bicycloamide derivative with a nucleic acid base or heterocyclic base or salt thereof in the presence of a transition metal catalyst to form a cyclopentenecarboxamide, and c) cleaving a carboxamide group from the cyclopentenecarboxamide to form the synthetic nucleoside. The processes according to the invention can be used for the synthesis of a variety of anti-viral agents, including Abacavir, Carbovir, and Entecavir, as well as derivatives thereof.

专利号:US-12331006-B2
优先权日:2018-05-25
标 题 :Process for the synthesis of (s) 3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid
发明人：SILVERMAN RICHARD B; MOSCHITTO MATTHEW
权利人:UNIV NORTHWESTERN
摘要:Provided herein are processes, compounds and compositions for making (S)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid. Also provided herein a pharmaceutical compositions containing (S)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid.

专利号:EP-3440041-A1
优先权日:2016-04-07
标 题:Synthesis of 2'-fluoro-6'-methylene-carbocyclic adenosine (fmca) and 2'-fluoro-6'-methylene-carbocyclic guanosine (fmcg)

专利号:WO-9703053-A1
优先权日:1995-07-10
标题 :N-(acyloxymethyl or hydroxymethyl) (optionally (oxa or thia) substituted)bicyclo([2.2.1] or [2.2.2])azalk(an or en)one compounds
发明人：PETRE DOMINIQUE; DARNAND ELIANE; MARSEIGNE ISABELLE; LEON PATRICK; BOTANNET DANIELLE
权利人:RHONE POULENC RORER PHARMA; PETRE DOMINIQUE; DARNAND ELIANE; MARSEIGNE ISABELLE; LEON PATRICK; BOTANNET DANIELLE
摘要:The present invention is directed to N-(acyloxymethyl or hydroxymethyl)-(optionally (oxa or thia) substituted)bicyclo([2.2.1] or [2.2.2])azalk(an or en)one compounds which are useful as intermediates in the synthesis of cardiovascular agents, including anti-anginal agents, antihypertensives and anti-ischemics, anti-viral agents, anti-neoplastic agents, antifungal agents and antimicrobial agents, and to their preparation.

专利号:EP-4410773-A2
优先权日:2018-05-25
标 题:Process for the synthesis of (s) 3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid