CAS: 1334-76-5; Methyl Furoate

专利信息

专利号:US-5292903-A
优先权日:1991-08-22
标 题:One step method for the preparation of difurfuryl diamines
发明人：CONNER ANTHONY H; HOLFINGER MICHAEL S; HILL JR CHARLES G; MCKILLIP WILLIAM J; REIMANN ROLF H
权利人:US DEPARTMENT OF AGRICULTURE A
摘要:A synthetic procedure for the synthesis of diamino difurfuryl compounds via a one-step, low-temperature reaction that does not require additional steps for the protection of the amino functionalities in the reactant or the deprotection of the amino functionalities in an intermediate product to give the final product is disclosed. The importance of acid concentration, reaction temperature, and reaction time to the one step method are disclosed.

专利号:US-7193077-B2
优先权日:2003-08-30
标 题 :Exocyclic amine triaryl methyl protecting groups in two-step polynucleotide synthesis
发明人：DELLINGER DOUGLAS J; SIERZCHALA AGNIESZKA B; CARUTHERS MARVIN H
权利人:AGILENT TECHNOLOGIES INC
摘要:Precursors for use in the synthesis of polynucleotides and methods of using the precursors in synthesizing polynucleotides are disclosed. The precursors include a heterocyclic base having an exocyclic amine group and a substituted or unsubstituted triaryl methyl protecting group bound to the exocyclic amine group.

专利号:US-7427679-B2
优先权日:2003-08-30
标 题:Precursors for two-step polynucleotide synthesis
发明人：DELLINGER DOUGLAS J; SIERZCHALA AGNIESZKA B; CARUTHERS MARVIN H
权利人:AGILENT TECHNOLOGIES INC
摘要:Precursors for use in the synthesis of polynucleotides are disclosed. The precursors include a heterocyclic base having an exocyclic amine group and a substituted or unsubstituted triaryl methyl protecting group bound to the exocyclic amine group. In particular embodiments, the precursor has the structure: n nwherein:n O and H represent oxygen and hydrogen, respectively, R 1 is hydrido, hydroxyl, protected hydroxyl, lower alkyl, modified lower alkyl, or alkoxy, one of R 2 or R 3 is a hydroxyl protecting group; and the other of R 2 or R 3 is a reactive group capable of reacting with a reactive site hydroxyl, Base is a heterocyclic base having an exocyclic amine group, and Tram is a triaryl methyl group having the structure (V) n nwherein the broken line represents a bond to the amino nitrogen of the exocyclic amine group, and R 4 , R 5 and R 6 are independently selected from unsubstituted or substituted aryl groups, provided that at least one of R 4 , R 5 , and R 6 is an aryl group other than phenyl and other than substituted phenyl.

专利号:US-7417139-B2
优先权日:2003-08-30
标 题 :Method for polynucleotide synthesis
发明人：DELLINGER DOUGLAS J; SIERZCHALA AGNIESZKA B; CARUTHERS MARVIN H; DELLINGER GERALDINE F
权利人:AGILENT TECHNOLOGIES INC
摘要:Methods of forming an internucleotide bond are disclosed. Such methods find use in synthesis of polynucleotides. The method involves contacting a functionalized support with a precursor having an exocyclic amine triaryl methyl protecting group under conditions and for a time sufficient to result in internucleotide bond formation. The functionalized support includes a solid support, a triaryl methyl linker group, and a nucleoside moiety having a reactive site hydroxyl, the nucleoside moiety attached to the solid support via the triaryl methyl linker group. In particular embodiments, the precursor has the structure: n nwherein:n O and H represent oxygen and hydrogen, respectively R1 is hydrido, hydroxyl, protected hydroxyl, lower alkyl, modified lower alkyl, or alkoxy, one of R2 or R3 is a hydroxyl protecting group; and the other of R2 or R3 is a reactive group capable of reacting with the reactive site hydroxyl, Base is a heterocyclic base having an exocyclic amine group, and Tram is the exocyclic amine triaryl methyl protecting group.

专利号:US-5278337-A
优先权日:1992-10-14
标 题:Enantiomeric resolution of aryl-substituted aliphatic carboxylic acids
发明人：MANIMARAN THANIKAVELU; STAHLY G PATRICK; HERNDON JR R CARL
权利人:ETHYL CORP
摘要:A process for obtaining a substantially pure enantiomer of an aryl-substituted aliphatic carboxylic acid is described. The process utilizes first an enantiomerically enriched mixture the of aryl-substituted aliphatic carboxylic acid obtained from kinetic resolution, diastereomeric crystallization or asymmetric synthesis processes. This enriched mixture is reacted with a base producing a salt that has the following properties: n 1) has at least one eutectic point; n 2) a composition that is not at the eutectic point; and n 3) a eutectic composition that is closer to the racemic composition than is the eutectic composition of said aryl-substituted carboxylic acid. n Substantially pure, enantiomeric salt is separated, leaving a mother liquor comprising the solvent and aryl-substituted aliphatic carboxylic acid enriched in the other enantiomer.

专利号:WO-2022069554-A1
优先权日:2020-10-01
标 题:Method for producing 4-bromfuran-2-carboxylates
发明人：REMBIAK ANDREAS
权利人:BAYER AG
摘要:The invention relates to a method for producing 4-bromofuran-2-carboxylates of general formula (I) and to the use thereof as important precursors for the synthesis of agrochemical and pharmaceutical active substances. (I).