CAS: 13408-56-5; Ponasterone A

上下游产品

Stachysterone C 25,26-didehydroponasterone A 2,3:20,22-di-O-isopropylideneponasterone A 20-hydroxyecdysone-2,3,22-triacetate20-Hydroxyecdysone inokosterone 25-deoxy-20-hydroxyecdyson-26-oic acid 20-hydroxyecdyson-26-oic acid

20-Hydroxyecdysone-2,3,22-Triacetate置于palladium On Activated Charcoal 吡啶,三氯氧磷,Potassium Carbonate,氢气体系中,用 甲醇 用作溶剂,化学反应生成松甾酮a
参考文献:Dimeric Ecdysteroid Analogues And Their Interaction With The Drosophila Ecdysteroid Receptor
标题:Dimeric Ecdysteroid Analogues And Their Interaction With The Drosophila Ecdysteroid Receptor
摘要:三种结构相关的特定类似激素类衍生物,即14-去氧-8(14)-烯类20-羟基脱氧雄甾酮的7,7'-二聚体,通过光化学转化得到,分别为20-羟基脱氧雄甾酮,波纳斯特龙a和阿苏龙c.二聚体激素的结构主要通过核磁共振光谱学鉴定,辅以质谱和红外光谱.二聚体生成产物的收率取决于反应物浓度和光反应条件.惰性气氛支持高产率,而氧气氛完全阻止了二聚体的形成.与相关原始激素相比,在果蝇bii生物检测中,这三种二聚体保留了相当高的激素受体激动活性.
Doi:10.1135/cccc20061229

专利信息

专利号:US-2022228171-A1
优先权日:2019-07-17
标 题 :Compositions and production of nicked closed-ended dna vectors
发明人：ALKAN OZAN; KOTIN ROBERT MICHAEL; KERR DOUGLAS ANTHONY; MONDS RUSSELL; PELLETIER CAROLYN; STANTON MATTHEW
权利人:GENERATION BIO CO
摘要:The present application discloses methods for synthetic production and cell-free synthesis of DNA vectors, particularly closed-ended linear DNA vectors having one or more gaps (e.g., nicked ceDNA vectors, “neDNAâ€?) and adenoassociated-virus (AAV) vector which is single strand DNA having linear and continuous structure, for delivery and expression of a transgene in the host cell. The present invention also relates to an in vitro process for production of closed-ended DNA vectors, corresponding DNA vector products produced by the methods and uses thereof, and oligonucleotides and kits useful in the process of the present invention.

专利号:US-2022220488-A1
优先权日:2019-07-17
标 题 :Synthetic production of single-stranded adeno associated viral dna vectors
发明人：ALKAN OZAN; KOTIN ROBERT MICHAEL; KERR DOUGLAS ANTHONY; MONDS RUSSELL; PELLETIER CAROLYN; STANTON MATTHEW
权利人:GENERATION BIO CO
摘要:The present application discloses methods for synthetic production and cell-free synthesis of single stranded adeno-associated virus (AAV) vectors, for delivery and expression of a transgene in host cells. The present invention also relates to an in vitro process for production of closed-ended DNA vectors and corresponding single stranded AAV DNA vector products synthesized from the closed-ended DNA vectors having nicks.

专利号:US-7235520-B2
优先权日:2000-09-21
标题:Method of inducing apoptosis in lymphoid cells
发明人：GREEN MICHAEL R; DEVIREDDY LAXMINARAYANA; TEODORO JOSE G; RICHARD FABIAN
权利人:UNIV MASSACHUSETTS
摘要:A two-stage, transcriptionally regulated apoptotic program has been discovered. In the first stage, IL-3 withdrawal results in transcriptional activation of the NGAL gene followed by synthesis and secretion of NGAL protein. In the second stage, secreted NGAL protein induces apoptosis in lymphoid cells by an autocrine mechanism. Based on this discovery, the invention provides a method of inducing apoptosis in a lymphoid cell in a mammal, e.g., a human patient. The invention includes administering a therapeutically effective amount of an NGAL polypeptide or NGAL-like polypeptide to a mammal.

专利号:US-2004091918-A1
优先权日:2002-08-01
标 题 :Methods and kits for synthesis of siRNA expression cassettes

专利号:US-7585497-B2
优先权日:2000-05-17
标 题:Induction of apoptosis and cell growth inhibition by protein 4.33
发明人：OH YOUNGMAN; ROSENFELD RON; INGERMANN ANGELA RENAE
权利人:UNIV OREGON HEALTH & SCIENCE
摘要:There is disclosed an isolated cDNA sequence (SEQ ID NO:1) encoding a P4.33 polypeptide and comprising a coding region (SEQ ID NO:2) of the sequence described in SEQ ID NO:1, or a sequence having at least 90% homology with the coding region of SEQ ID NO:1. The P4.33 polypeptide functions as a specific cell-surface receptor for IGFBP-3, and undergoes nuclear translocation in combination with IGFBP-3. IGFBP-3 and P4.33 (IGFBP-3R) cooperatively suppress DNA synthesis and cell growth, and induce caspase activation and apoptosis in cancer cells, indicating that P4.33 is an important mediator of IGF-independent growth inhibitory actions of IGFBP-3. The P4.33:IGFBP-3 system of the present invention can be used, inter alia, in screening and diagnostic assays, and for therapeutic methods for cancer treatment and tumor suppression.

专利号:US-8389244-B2
优先权日:2002-08-01
标 题 :Methods and kits for synthesis of siRNA expression cassettes