CAS: 153-98-0; Serotonin Hydrochloride

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CAS号108560-71-0 3-(2-Aminoethyl... | CAS号608-07-1 5-甲氧基色胺 | CAS号487-93-4 蟾蜍色胺 | CAS号1892-21-3 2-(5-hydroxy-1H... | CAS号3000-36-0 1H-Pyrido[3,4-b... | CAS号374680-35-0 3,4,5,6-tetrahy... | CAS号20776-45-8 5-苄氧基色胺 | CAS号73-31-4 褪黑素 | CAS号53157-50-9 BENZYL[2-(5-HYD... | CAS号52055-23-9 5-苄氧基色胺盐酸盐

N-叔-丁基氧羰基血清素置于盐酸体系中,用 甲醇,水,乙酸乙酯 用作溶剂,化学反应 0.17H,反应生成5-羟基色胺盐酸盐
参考文献:一种利用含5-羟色胺的酶催化发酵液制备5-羟色胺盐酸盐的方法
标题:一种利用含5-羟色胺的酶催化发酵液制备5-羟色胺盐酸盐的方法
摘要:本发明公开一种利用含5‑羟色胺的酶催化发酵液中制备5‑羟色胺盐酸盐的方法,涉及5‑羟色胺提取技术领域,包括将含5‑羟色胺的酶催化发酵液经减压浓缩后和有机溶剂混合,低温条件下依次滴加三乙胺,Boc酸酐,滴加结束后升温至20‑25oc反应得到n‑boc‑5‑羟色胺反应液,加入乙酸乙酯萃取得乙酸乙酯有机相;向乙酸乙酯有机相中加入含有盐酸的乙酸乙酯反应,反应结束后抽滤得5‑羟色胺盐酸盐粗产物;将所得5‑羟色胺盐酸盐粗产物进一步纯化得5‑羟色胺盐酸盐.通过对酶催化发酵液中5‑羟色胺提纯方法的优化,制得高纯度的5‑羟色胺盐酸盐,改变酶催化发酵液中5‑羟色胺难以通过简单的提取来制得5‑羟色胺盐酸盐的现状.

专利信息

专利号:US-11485734-B2
优先权日:2018-10-02
标 题:Beta-carbolines as positive allosteric modulators of the human serotonin receptor 2C (5-HT2C)
发明人：SCHEIDT KARL A; MELTZER HERBERT Y; CSAKAI ADAM J
权利人:UNIV NORTHWESTERN
摘要:Disclosed are novel small molecules, methods of synthesis of the small molecules, and uses of the small molecules for modulating activity of the human serotonin receptor 2C (5-HT 2c ), preferably selectively. The small molecules have a substituted beta-carboline core structure, which optionally may be saturated at one or more bonds to provide a dihydro-beta-carboline core or a tetrahydro-beta-carboline core. The small molecules may be administered to treat and/or prevent diseases, disorders, and/or conditions associated with human serotonin receptor 2C (5-HT 2C ) including psychiatric, mental, and/or neurological diseases, disorders, and conditions such as cognitive impairment, addiction, and obsessive compulsive disorder. The disclosed small molecules also may be administered to treat and/or prevent obesity, for example, via appetite suppression.

专利号:US-2024366804-A1
优先权日:2021-07-30
标题 :Biocompatible imaging particles, their synthesis and use in imaging techniques
发明人：BONNARD THOMAS; JACQMARCQ CHARLÈNE; GAUBERTI MAXIME; MARTINEZ DE LIZARRONDO SARA; VIVIEN DENIS
权利人:INST NAT SANTE RECH MED; UNIV CAEN; CENTRE HOSPITALIER UNIV DE CAEN NORMANDIE
摘要:The present invention relates to novel biocompatible imaging particles comprising superparamagnetic iron oxide (SPIO) assembled into submicromiter-sized clusters within a biodegradable polycathecolamine or polyserotonine matrix, their synthesis and use in imaging techniques. These particles overcome the issues of toxicity and unreliable signal of the molecules from the prior art by providing similar contrast to that of the microparticles of iron oxide and rapidly disassemble into isolated SPIO particles once they reach the acidic lysosomal compartment of the MPS cells, thus enabling their digestion. The present invention is thus directed to a particle having a hydrodynamic diameter comprised between 100 nm and 2000 nm, said particle comprising nanoparticles of iron oxide embedded within a matrix of polycathecolamine or polyserotonine, each of said nanoparticles of iron oxide being coated by a polymer which is different from polycathecolamine or polyserotonine

专利号:US-10618030-B2
优先权日:2016-06-30
标 题:Metal oxide-based biocompatible hybrid sorbent for the extraction and enrichment of catecholamine neurotransmitters and related compounds, and method of synthesis
发明人：MALIK ABDUL; ALHENDAL ABDULLAH AWADH
权利人:UNIV SOUTH FLORIDA
摘要:The subject invention concerns metal or metalloid oxide-based sol-gel hybrid sorbent and methods of synthesis. In one embodiment, the sorbent is a ZrO 2 polypropylene oxide based sol-gel. The subject invention also concerns a hollow tube or capillary internally coated with a sorbent of the invention. Sorbent coated tubes and capillaries of the invention can be used in extraction and/or enrichment of samples to be analyzed for catecholamines and related compounds.

专利号:US-9550000-B2
优先权日:2011-09-09
标题 :Compositions, methods, and systems for the synthesis and use of imaging agents
发明人：ROBINSON SIMON P; YU MING
权利人:ROBINSON SIMON P; YU MING; LANTHEUS MEDICAL IMAGING INC
摘要:The present invention relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, the imaging agent is enriched in 18 F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs. In some embodiments, methods and compositions for assessing perfusion and innervation mismatch in a portion of a subject are provided.

专利号:CN-118562906-A
优先权日:2024-07-31
标题 :Application of OsSNAT4 protein and its encoding gene in catalyzing the synthesis of N-acetyl-5-hydroxytryptamine from 5-hydroxytryptamine

专利号:CN-118879805-A
优先权日:2024-08-02
标题:AtSNAT4 protein and application of coding gene thereof in catalyzing synthesis of N-acetyl-5-hydroxytryptamine from 5-hydroxytryptamine