CAS: 193885-59-5; Fmoc-Octyl-Gly-Oh

相似化合物

67862-03-7 84277-81-6 888725-91-5

上下游产品

(S)-N-Fmoc-2-(7’-辛烯基)甘氨酸 (S)-2-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)Amino)Dec-9-Enoic Acid 1262886-64-5
Fmoc-L-烯丙基甘氨酸 2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-Pent-4-Enoic Acid 146549-21-5
氯甲酸-9-芴基甲酯 (Fluorenylmethoxy)Carbonyl Chloride 28920-43-6
9-芴甲基-N-琥珀酰亚胺基碳酸酯 N-(9H-Fluoren-2-Ylmethoxycarbonyloxy)Succinimide 82911-69-1

(2S)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)Dec-4-Enoic Acid置于氢气体系中,用 甲醇 用作溶剂,20.0 °C,413.69 Kpa 条件下,以88.5 Mg的收率获得(S)-N-Fmoc-辛基甘氨酸
参考文献:串联钌-亚烷基催化的交叉复分解/氢化:亲脂氨基酸的合成.
标题:串联钌-亚烷基催化的交叉复分解/氢化:亲脂氨基酸的合成.
摘要:脂质氨基酸的高效合成可以通过ru-亚烷基催化的长链烯烃与市售的烯丙基甘氨酸的交叉复分解反应实现.然后可以通过使用废复分解催化剂在温和的反应条件下任选地将所得的不饱和类似物氢化.版权所有©2013欧洲多肽协会和john Wiley&sons,Ltd.
Doi:10.1002/psc.2522

专利信息

专利号:US-2015148524-A1
优先权日:2012-07-06
标题:Amino acid analogues and methods for their synthesis
发明人：WANG ZHEN; ROBINSON ANDREA; SPICCIA NICOLAS DANIEL; JACKSON WILLIAM ROY
权利人:UNIV MONASH
摘要:A method for the synthesis of an amino acid analogue or a salt, solvate, derivative, isomer or tautomer thereof comprising the steps of: (i) subjecting an amino acid containing a metathesisable group to metathesis with a compound containing a complementary metathesisable group of formula (I) or (II): (Formulae (I), (II)) wherein R 1 and R 2 are independently selected from H and substituted or unsubstituted C 1 to C 4 alkyl; each R 3 is either absent or independently selected from a heteroatom, a substituted or unsubstituted C 1 to C 20 alkyl, and a substituted or unsubstituted C 1 to C 20 alkyl group interrupted by one or more heteroatoms; and each X is independently selected from H and an effector molecule; in the presence of a reagent to catalyse the metathesis to form a dicarba bridge between the amino acid containing a metathesisable group and the compound containing a complementary metathesisable group; and (ii) reducing the dicarba bridge to form a saturated dicarba bridge, wherein the reagent used to catalyse step (i) also catalyses step (ii).