CAS: 214210-21-6; 3-Cyano-4-Fluorobenzeneboronic Acid

上下游产品

CAS号5419-55-6 硼酸三异丙酯 | CAS号179897-89-3 5-溴-2-氟苯腈 | CAS号73183-34-3 双戊酰二硼 | CAS号105942-08-3 4-溴-2-氟苯腈

2-氟-5-溴苯腈置于正丁基锂,硼酸三异丙酯,盐酸,水体系中,用 四氢呋喃,正己烷,甲苯 用作溶剂,化学反应 1.0H,反应生成3-氰基-4-氟苯硼酸
参考文献:Wo2006/45350
标题:Wo2006/45350

专利信息

专利号:US-9744252-B2
优先权日:2011-08-17
标 题:Compounds for binding to the platelet specific glycoprotein IIb/IIIa and their use for imaging of thrombi
发明人：BERGER MARKUS; KRUGER MARTIN; LOHRKE JESSICA; REINHARDT MICHAEL; SIEBENEICHER HOLGER
权利人:PIRAMAL IMAGING SA
摘要:The present invention relates to novel fluorine containing compounds, methods for their preparation, the intermediates of the synthesis, their use as diagnostic agents, especially for imaging of thrombi. The invention relates to positron emission tomography (PET) agents and associated precursor reagents, and methods for producing such radiolaveled agents for imaging of thrombi in a mammalian body. More particularly, the invention relates to small nonpeptide, high-affinity, specific-binding glycoprotein IIb/IIIa antagonists for imaging of thrombi.

专利号:US-8507538-B2
优先权日:2009-11-13
标 题:Selective heterocyclic sphingosine 1 phosphate receptor modulators
发明人：BOEHM MARCUS F; MARTINBOROUGH ESTHER; BRAHMACHARY ENUGURTHI; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; YEAGER ADAM RICHARD
权利人:BOEHM MARCUS F; MARTINBOROUGH ESTHER; BRAHMACHARY ENUGURTHI; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; YEAGER ADAM RICHARD; RECEPTOS INC
摘要:Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds is provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.

专利号:US-9481659-B2
优先权日:2011-05-13
标 题 :Selective heterocyclic sphingosine 1 phosphate receptor modulators
发明人：BOEHM MARCUS F; MARTINBOROUGH ESTHER; BRAHMACHARY ENUGURTHI; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; YEAGER ADAM RICHARD
权利人:BOEHM MARCUS F; MARTINBOROUGH ESTHER; BRAHMACHARY ENUGURTHI; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; YEAGER ADAM RICHARD; CELGENE INT II SÀRL
摘要:Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds is provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.