CAS: 23513-14-6; (S)-5-Hydroxy-1-(4-Hydroxy-3-Methoxyphenyl)Decan-3-One

该化合物是一种从Zingiber officinale 中提取的自然产生的姜树酮化合物. 这种生物活性分子表现出强大的抗炎和抗氧化性特性,有助于其在疼痛管理,炎症调控和氧化性应激反应缓解方面的潜在治疗应用.

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上下游产品

1-(4-benzyloxy-3-methoxyphenyl)-5-hydroxydecan-3-one (R)-3-[2-(4-Benzyloxy-3-methoxy-phenyl)-ethyl]-5-((1E,3E)-penta-1,3-dienyl)-4,5-dihydro-isoxazole 3-(4-hydroxy-3-methoxyphenyl)acrylic acid 3-(4-hydroxy-3-methoxyphenyl)propionic acid [6]-shogaol [6]-shogaol -diacetylgingerol6-diacetylgingerol 4-(3,4-dimethoxy-phenyl)-butan-2-one

合成工艺路线路线简述

    3-(4-羟基-3-甲氧基苯基)丙酸置于四甲基乙二胺,硫酸,四丁基碘化铵,镍,Sodium Hydride,Lithium Diisopropyl Amide,儿萘酚硼烷体系中,用 四氢呋喃,乙醇,二甲基亚砜 用作溶剂,化学反应 19.25H,反应生成6-姜酚
    参考文献:Solladie,Guy; Ghiatou,Nasser,Bulletin De La Societe Chimique De France,1994,Vol. 131,P. 575-578
    标题:Solladie,Guy; Ghiatou,Nasser,Bulletin De La Societe Chimique De France,1994,Vol. 131,P. 575-578

    海关参考信息

    专利信息


    专利号:US-12428442-B2
    优先权日:2017-06-21
    标题 :Compounds, compositions and methods for synthesis
    发明人:BUTLER DAVID CHARLES DONNELL; HENCKEN CHRISTOPHER P; IWAMOTO NAOKI; KANDASAMY PACHAMUTHU; LANAO ALVARO ANDRES; LU GENLIANG; SHIMIZU MAMORU; DIVAKARAMENON SETHUMADHAVAN; VARGEESE CHANDRA; BOMMINENI GOPAL REDDY; MARAPPAN SUBRAMANIAN
    权利人:WAVE LIFE SCIENCES LTD
    摘要:The present disclosure, among other things, provides technologies for synthesis, including reagents and methods for stereoselective synthesis. In some embodiments, the present disclosure provides compounds useful as chiral auxiliaries. In some embodiments, the present disclosure provides reagents and methods for oligonucleotide synthesis. In some embodiments, the present disclosure provides reagents and methods for chirally controlled preparation of oligonucleotides. In some embodiments, technologies of the present disclosure are particularly useful for constructing challenging internucleotidic linkages, providing high yields and stereoselectivity.

    专利号:US-2018105546-A1
    优先权日:2011-06-14
    标题:Methods for Chemical Synthesis of Biologically Active Compounds Using Supramolecular Protective Groups and Novel Compounds Obtainable Thereby

    专利号:US-6316465-B1
    优先权日:1998-06-27
    标 题:Ophthalmic uses of PPARgamma agonists and PPARgamma antagonists
    发明人:PERSHADSINGH HARRIHAR A; LEVY DANIEL E
    权利人:PHOTOGENESIS INC
    摘要:Methods of treating diseases of ocular tissues expressing the nuclear receptor PPARgamma, by inhibiting the inflammatory response, the neovascularization and angiogenesis, and programmed cell death (apoptosis) in these target tissues, comprising administering to a human or animal in need of treatment an effective amount of a compound that modifies the activity of PPARgamma, or pharmaceutically acceptable salts and solvates thereof.Novel compounds and methods for their synthesis are provided, including a compound having the general structure:

    专利号:US-2016271177-A1
    优先权日:2015-03-18
    标 题:Process for bio synthesis of nano arsenic trioxide and its use in treatment of diseases including cancer

    专利号:WO-2024215360-A2
    优先权日:2022-05-08
    标 题 :Synthesis of shape-controlled polymer nano/microstructures using initiated chemical vapor deposition (icvd) polymerization in structured liquids

    专利号:US-2014243280-A1
    优先权日:2011-06-14
    标题:Methods for chemical synthesis of biologically active compounds using supramolecular protective groups and novel compounds obtainable Thereby
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    主要参考文献


    1: Liu W, Zhou CL, Zhao J, Chen D, Li QH. Optimized microwave-assisted extraction of 6-gingerol from Zingiber officinale Roscoeand evaluation of antioxidant activity in vitro. Acta Sci Pol Technol Aliment. 2014 Apr-Jun;13(2):155-68. Chinese. doi: 10.3389/fphar.2013.00141. eCollection 2013.
    5: Kim SO, Kim MR. [6]-Gingerol Prevents Disassembly of Cell Junctions and Activities of MMPs in Invasive Human Pancreas Cancer Cells through ERK/NF- κ B/Snail Signal Transduction Pathway. Evid Based Complement Alternat Med. 2013;2013:761852. doi: 10.1155/2013/761852. Epub 2013 Sep 24.
    6: Li Y, Tran VH, Koolaji N, Duke C, Roufogalis BD. (S)-[6]-Gingerol enhances glucose uptake in L6 myotubes by activation of AMPK in response to [Ca2+]i. J Pharm Pharm Sci. 2013;16(2):304-12. doi: 10.1155/2013/951758. Epub 2013 Jul 17.

    合成参考文献


    参考文献:10.1002/jssc.200900629
    摘要:Khan I, Pandotra P, Gupta AP, Sharma R, Gupta BD, Dhar JK, Ram G, Bedi YS, Gupta S. RP‐thin layer chromatographic method for the quantification of three gingerol homologs of ultrasonic‐assisted fresh rhizome extracts of Zingiber officinale collected from North Western Himalayas. J of Separation Science. 2010 Mar;33(4-5):558–63. doi: 10.1002/jssc.200900629.
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