CAS: 2386-57-4; Sodium Methanesulfonate

相似化合物

2386-52-9 2550-61-0 22515-76-0

上下游产品

CAS号75-75-2 甲基磺酸 | CAS号1912-32-9 甲烷磺酸丁酯 | CAS号123-95-5 硬脂酸丁酯 | CAS号57-11-4 硬脂酸 | CAS号66-27-3 甲基磺酸甲酯 | CAS号16156-52-8 °Ctyl methanesu... | CAS号16562-77-9 sodium 2-oxopro... | CAS号80653-56-1 N,N-Dimesyl-O-m... | CAS号532-32-1 苯甲酸钠 | CAS号924-80-1 methanesulfonic... | CAS号1950-85-2 硫甲磺酸钠 | CAS号254878-95-0 3-氟-4-(甲基磺酰基)苯甲醛 | CAS号28995-82-6 Benzene,[1-iodo... | CAS号82956-11-4 甲磺酸萘莫司他 | CAS号15436-11-0 (E)-(2-(Methyls... | CAS号61081-34-3 1-[(甲基磺酰基)甲基]-4-硝基苯 | CAS号41138-92-5 甲磺酰溴

甲基磺酰氯 在 碳酸氢钠,Sodium Sulfite体系中,用 水作为反应溶剂,反应 2.25H,以93%的收率获得methanesulfonic Acid Sodium Salt
参考文献:发现,合成和评估的ketol酸还原异构酶抑制剂.
标题:发现,合成和评估的ketol酸还原异构酶抑制剂.
摘要:支链氨基酸生物合成途径中的第二种酶-酸还原酶(Kari)是细菌感染的潜在药物靶标,包括结核分枝杆菌.在这里,我们已经针对纯净的结核分枝杆菌(Mt)Kari筛选了用于疟疾风险病原体药箱的药物,并确定了两个k I值低于200 N M的化合物.在山细胞敏感性测定这些化合物中的一种表现出的ic 50为0.8μ值米.该化合物3-(((甲基磺酰基)甲基)-2-H-苯并[ B]的共结晶] [1,4]恶嗪-2-酮(Mmv553002)与金黄色葡萄球菌kari的复合物与mt Kari,Nadph和mg 2+具有56%的同一性,其结构分辨率为1.72å.但是,在活性位点仅观察到了抑制剂的水解产物(即3-(甲基磺酰基)-2-氧代丙酸,缺少2-氨基苯酚的连接).令人惊讶的是,山细胞敏感性试验表明,2-氨基苯酚产物在很大程度上负责母体化合物的抗tb活性.因此,3-(甲基磺酰基)-2-氧代丙酸被确定为有效的kari
Doi:10.1002/Chem.202000899

专利信息

专利号:US-2015080598-A1
优先权日:2012-03-30
标题:Asymmetric synthesis for preparing fluoroleucine alkyl esters
发明人：HUMPHREY GUY; CHUNG CHEOL; RIVERA NELO; BELYK KEVIN
权利人:MERCK SHARP & DOHME
摘要:The instant invention describes a novel asymmetric synthesis of fluoroleucine alkyl esters which utilizes a phase transfer catalyst and a solid additive.

专利号:US-6114523-A
优先权日:1997-10-22
标题:Process for the recycle of a waste product of diltiazem synthesis
发明人：ALLEGRINI PIETRO; MARCHIORO GAETANO; BARRECA GIUSEPPE; VILLA MARCO; RUSSO LAURA
权利人:ZAMON GROUP S P A
摘要:A process which allows the re-use of compounds of formula ##STR1## in diltiazem synthesis through a process of conversion to a mixture of enantiomers III-(2R,3R) and III-(2S,3S) is described.

专利号:US-4950368-A
优先权日:1989-04-10
标 题 :Method for paired electrochemical synthesis with simultaneous production of ethylene glycol
发明人：WEINBERG NORMAN L; GENDERS JOHN D; MAZUR DUANE J
权利人:ELECTROSYNTHESIS CO INC; SKA ASS
摘要:Paired electrochemical synthesis reactions in which ethylene glycol is formed at the cathode of a membrane divided cell at high concentrations and current efficiencies, up to 99 percent. Simultaneously, a compatible process is also conducted at the anode of the same electrochemical cell by reacting indirectly generated anode products with organic substrates to form secondary products, such as polybasic acids. The process is especially advantageous in that such secondary products, where appropriate can be further reacted with the ethylene glycol prepared from the catholyte of the same cell to form useful tertiary products, especially polyesters like polyethylene terephthalate. Mole ratios of ethylene glycol and polybasic acid can be controlled through selective use of regeneratable redox reactant.

专利号:US-9200118-B2
优先权日:2010-09-14
标 题 :Quaternised polybenzimidazole
发明人：KHARUL ULHAS KANHAIYALAL; KUMBHARKAR SANTOSH CHANDRAKANT; BHAVSAR RUPESH SUDHAKAR
权利人:KHARUL ULHAS KANHAIYALAL; KUMBHARKAR SANTOSH CHANDRAKANT; BHAVSAR RUPESH SUDHAKAR; COUNCIL SCIENT IND RES
摘要:The invention discloses polymeric forms of ionic liquids, PFILs, based on polybenzimidazole (PBI) and a process for the synthesis of such polymeric forms of ionic liquids. The invention also relates to use of PBI based polymeric forms of ionic liquids and their membranes for gas sorption, permeation and separation.

专利号:US-4002459-A
优先权日:1974-04-18
标题 :Germination factors
发明人：JOHNSON ALAN W; ROSEBERY GERALD
权利人:INT DEV RESEARCH CENTER
摘要:Active compounds, some of which are new, are described for the control of various parasitic weeds of the genus Striga and Orobanche. These compounds all include cyclic lactone structures and are related to the naturally occurring substance strigol. Methods of synthesis of the compounds are given, as well as compositions and methods for controlling the parasitic weeds.

专利号:US-9505799-B2
优先权日:2011-05-13
标题:18F-labeled precursor of PET radioactive medical supplies, and preparation method thereof
发明人：CHI DAE-YOON; LEE BYOUNG-SE; PARK CHANSOO; LEE MIN-HYUNG; CHA HYOJIN; CHO WOOJIN; KANG HEEWON; KIM KYUNGHUN
权利人:CHI DAE-YOON; LEE BYOUNG-SE; PARK CHANSOO; LEE MIN-HYUNG; CHA HYOJIN; CHO WOOJIN; KANG HEEWON; KIM KYUNGHUN; FUTURECHEM CO LTD
摘要:The present invention relates to a precursor of positron emission tomography (PET) radioactive medical supplies, a preparation method thereof, and an application thereof, and more specifically, to a precursor having a tetravalent organic salt leaving group, a preparation method, and a method for preparing desired PET radioactive medical supplies in a high radiochemical yield within a short preparation time by introducing 18 F using the same through a single step. The precursor having a tetravalent organic salt leaving group of the present invention can simplify the known complex multistep preparation of radioactive medical supplies into a single step, can save production costs because an excessive amount of a phase transfer catalyst is not required, facilitates separation of a compound after reaction, and enables rapid reaction velocity. The features are appropriate for the mass production of PET radioactive medical supplies by an automated synthesis system.