专利号:US-2005043532-A1 优先权日:2003-08-22 标 题 :Direct synthesis of di-heteroatom containing cyclic organic compounds 发明人:SISKIN MICHAEL; MOZELESKI EDMUND J 摘要:The present invention provides for the simplified, direct synthesis of di-heteroatom containing cyclic organic compounds by forming an aqueous mixture of material of the formula 1 n n nwherein X and Y are heteroatoms which may be the same or different and X is selected from the group consisting of O, S and N, and both Y's are the same and are selected from the group consisting of O, S and N, and R 1 through R 8 are the same or different and are selected from the group consisting of H, C 1 to C 10 alkyl radicals, C 1 to C 10 aryl radicals, C 1 to C 10 alkyl aryl radicals, and z is zero when X and Y are O or S, and z is 1 when X and Y are N, and water at a mole ratio of water to material of formula I in the range of about 10:1 to about 0.001:1 and heating the mixture to a temperature in the range of about 250° C. to about 350° C. under autogeneous pressure for a time of from about 0.5 to 10 hours. Trace amounts of liquid, solid or gaseous acid can be present to further accelerate dehydration, dehydrosulfurization or deamination and cyclization.
专利号:US-9475780-B2 优先权日:2011-07-20 标 题 :Process for the synthesis of cyclic alkylene ureas 发明人:GUPTA RAM; KOBYLANSKA IRINA; TREASURER URVEE; FLOOD LAWRENCE 权利人:GUPTA RAM; KOBYLANSKA IRINA; TREASURER URVEE; FLOOD LAWRENCE; ALLNEX IP S AR L 摘要:The invention relates to a process for the synthesis of cyclic alkylene ureas comprising reacting in the presence of a basic catalyst, a difunctional amine A having two primary amino groups, and an aliphatic organic carbonate component C selected from the group consisting of dialkyl carbonates CD and of alkylene carbonates CA, wherein the ratio of the amount of substance Ji(—NH2) of primary amino groups —NH2 in the difunctional amine A to the sum M(C) of the amount of substance n(CD) of carbonate groups of a dialkyl carbonate CD and the amount of substance n(CA) of carbonate groups in an alkylene carbonate CA, is at least more than 2, and to the product obtained by this process.
专利号:US-10995076-B2 优先权日:2017-05-24 标 题:Halogenated benzoxazine for use in the synthesis of polybenzoxazine 发明人:FEDURCO MILAN; RIBEZZO MARCO 权利人:MICHELIN & CIE 摘要:A halogenated benzoxazine compound, which can be used in particular as monomer in the synthesis of polybenzoxazine, corresponds to the formula (the symbol Hal representing at least one halogen): n nin which: each benzene nucleus bears at least one halogen; R 1 and R 2 , which are identical or different, represent hydrogen or an alkyl comprising from 1 to 8 carbon atoms; “x 1 â€? and “x 2 â€?, which are identical or different, are integers equal to or greater than 1; “x 3 â€? is an integer equal to or greater than 1; and X is a heteroatom chosen from O and S.
专利号:US-10800795-B2 优先权日:2017-05-31 标 题:Borated benzoxazine for use in the synthesis of polybenzoxazine 发明人:FEDURCO MILAN; RIBEZZO MARCO 权利人:MICHELIN & CIE 摘要:A borated benzoxazine compound, which can be used in particular as monomer in the synthesis of polybenzoxazine, corresponds to the formula: n nin which: Z represents an at least divalent, aliphatic, cycloaliphatic or aromatic, bonding group comprising at least one carbon atom and optionally at least one heteroatom chosen from O, S and P; and R 1 , R 2 , R 3 and R 4 , which are identical or different, represent hydrogen or an alkyl comprising from 1 to 12 carbon atoms, it being possible for R 1 and R 2 , on the one hand, and R 3 and R 4 , on the other hand, optionally to form a heterocycle with the two oxygen atoms and the boron atom to which they are respectively bonded.
专利号:US-5674729-A 优先权日:1991-06-24 标 题 :De novo cell-free synthesis of picornavirus 发明人:WIMMER ECKARD; MOLLA AKHTERUZZAMAN; PAUL ANIKO V 权利人:UNIV NEW YORK STATE RES FOUND 摘要:A process for the de novo synthesis of a picornavirus using a cell-free medium has been developed. The cell-free medium is prepared from a lysate of mammalian cells from which the nuclei and mitochondria has been removed, endogenous mRNA deactivated and supplemented with nucleoside triphosphates, tRNA, amino acids and precursors necessary for generating proteins. The genomic RNA of the picornavirus or rhinovirus is added to the cell-free medium and after incubation at about 30° C. to 40° C. of from about 4 to 24 hours infectious, mature virus particles are formed.
专利号:US-5329022-A 优先权日:1991-01-16 标 题:Process for the synthesis of citraconimides 发明人:TALMA AUKE G; HOOFT HENDRIKA P M; VAN DE BOVENKAMP-BOUWMAN ANNA 权利人:AKZO AMERICA INC 摘要:The present invention relates to an improved synthesis method for the making of citraconimides wherein a citraconic anhydride is reacted with 0.5 to 2.0 equivalents of at least one amine salt. This process may be carried out in a solvent and generally leads to excellent yields of the citraconimides with high selectivity and easy purification. The present inventional so relates to a process for the production of citraconic anhydride from itaconic anhydride with an amine or phosphine catalyst and in a cosolvent.
1: Pignatello R, Impallomeni G, Pistarà V, Cupri S, Graziano AC, Cardile V, Ballistreri A. New amphiphilic derivatives of poly(ethylene glycol) (PEG) as surface modifiers of colloidal drug carriers. III. Lipoamino acid conjugates with carboxy- and amino-PEG(5000) polymers. Mater Sci Eng C Mater Biol Appl. 2015 Jan;46:470-81. doi: 10.1016/j.msec.2014.10.054. Epub 2014 Oct 23. doi: 10.1039/c0cc02615h. Epub 2010 Nov 26. doi: 10.1016/j.jpba.2010.07.008. Epub 2010 Aug 1. doi: 10.1039/b811818c. Epub 2008 Sep 16.
合成参考文献
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