乙酰丙酸置于双氧水,Potassium Hydroxide体系中,用 水 作为反应溶剂,化学反应 1.0H,以45%的收率获得产物3-羟基丙酸 参考文献: Preparation Of Compounds From Levulinic Acid[fr] Préparation De Composés à Partir D'Acide Lévulinique 标题: Preparation Of Compounds From Levulinic Acid[fr] Préparation De Composés à Partir D'Acide Lévulinique 摘要:本发明提供了一种从γ-戊内酸制备羧酸的方法,例如琥珀酸和3-羟基丙酸,通过将γ-戊内酸与过氧化氢在酸性或碱性条件下反应.
专利号:WO-2012017400-A1 优先权日:2010-08-03 标 题 :Synthesis of acyl-pantetheine derivatives and the use thereof in the synthesis of acyl-coenzyme a derivatives 发明人:VAN DIJK ALBERDINA AIKE; BADENHORST CHRISTOFFEL PETRUS STEPHANUS 权利人:UNIV NORTHWEST; VAN DIJK ALBERDINA AIKE; BADENHORST CHRISTOFFEL PETRUS STEPHANUS 摘要:The present invention relates to a novel synthesis method for acyl-pantetheine derivatives. The present invention further relates to the use of said synthesized acyl-pantetheine derivatives as a starting material in the enzymatic synthesis of acyl-coenzyme A derivatives. According to a first aspect thereof, the present invention provides a method for the synthesis of acyl-pantetheine derivatives, the method including the steps of: a) providing a source of pantetheine; b) providing a source of acyl ester; and c) contacting the source of pantetheine with the source of acyl ester to form the corresponding acyl-pantetheine derivative, having the general formula (I), wherein R is an acyl group.The present invention also provides a method for the synthesis of acyl-coenzyme A derivatives as well as the use of a source of pantetheine and a source of acyl ester in the preparation steps of these two methods.
专利号:US-11512303-B2 优先权日:2017-05-27 标 题 :Engineered polypeptides and their applications in the synthesis of beta-hydroxy-alpha-amino acids 发明人:CHEN HAIBIN; BONG YONG KOY; XU QING; ZHOU AMENG; SHEN TIANRAN; YANG JIADONG; YANG ZHUHONG 权利人:ENZYMASTER NINGBO BIO ENG CO LTD 摘要:The present invention provides engineered polypeptides that are useful for the asymmetric synthesis of β-hydroxy-α-amino acids under industrial-relevant conditions. The engineered polypeptides disclosed in this invention were developed through directed evolution based on the ability of catalytic synthesis of (2S, 3R)-2-amino-3-hydroxy-3-(4-nitrophenyl) propanoic acid. The present disclosure also provides polynucleotides encoding engineered polypeptides, host cells capable of expressing engineered polypeptides, and methods of producing β-hydroxy-α-amino acids using engineered polypeptides. Compared to other processes of preparation, the use of the engineered polypeptides of the present invention for the preparation of β-hydroxy-α-amino acids results in high purity of the desired stereoisomers, mild reaction conditions, low pollution and low energy consumption. So, it has good industrial application prospects.
专利号:US-9035013-B2 优先权日:2010-08-04 标 题 :Sulphur-containing triazine monomer that can be used for the synthesis of a polymer membrane for a fuel cell 发明人:FEDURCO MILAN 权利人:FEDURCO MILAN; MICHELIN & CIE; MICHELIN RECH TECH 摘要:A sulphur-containing triazine monomer is provided that can be used in the synthesis of a polymer membrane for a PEM-type fuel cell. The sulphur-containing triazine monomer has a structure corresponding to a formula (I): n nin which:n Tz represents a 1,3,5-triazine nucleus; X 1 and X 2 , which are identical or different, represent S, SO, or SO 2 ; Ar 1 , Ar 2 , Ar 4 and Ar 5 , which are identical or different, represent a substituted or unsubstituted phenylene group; Ar 3 represents a substituted or unsubstituted phenyl group; and Z 1 and Z 2 , which are identical or different, are selected from a group that includes halogens, hydroxyl, alkoxyl, thiol, carboxyl, carboxylates, amine, sulphonamide, acyl chlorides, sulphonyl chlorides, sulphonyl fluorides, isocyanates, and combinations thereof.
专利号:US-7582758-B2 优先权日:2004-06-08 标 题:Lewis acid mediated synthesis of cyclic esters 发明人:MARTIN KEVIN V 权利人:METABASIS THERAPEUTICS INC 摘要:Methods for the synthesis of cyclic phosphonic acid diesters from 1,3-diols are described, whereby cyclic phosphonic acid diesters are produced by reacting a chiral 1,3-diol and an activated phosphonic acid in the presence of a Lewis acid.
专利号:EP-0097994-B1 优先权日:1982-06-24 标 题:Method for the solid-phase synthesis of retro-inverso polypeptides 摘要:This invention relates to a method for the solid-phase synthesis of polypeptides containing retro-inverted peptide bonds, using polydimethylacrylamide-co-acryloylsarcosimethylester resin cross-linked with N, N min -ethylene-bis-acrylamide as the insoluble support for lengthening the polypeptide chain in stages by the addition of suitable amino acid derivatives and/or peptides in succession. In particular, the method described in the present invention allows the easy preparation, on the polymer matrix, of monoacylated gem-diamino residues using the reagent I, I-bis (trifluoroacetoxy) iodobenzene in mixed aqueous-organic solvents.
专利号:US-6903044-B2 优先权日:2001-05-18 标题:One-step production of 1,3-propanediol from ethylene oxide and syngas with a catalyst with a N-heterocyclic ligand 发明人:KNIFTON JOHN FREDERICK; JAMES TALMADGE GAIL; ALLEN KEVIN DALE; WEIDER PAUL RICHARD; POWELL JOSEPH BROUN; SLAUGH LYNN HENRY; WILLIAMS TIMOTHY 权利人:SHELL OIL CO 摘要:Disclosed is a new catalyst composition comprising a bimetallic Co—Ru catalyst complexed with a N-heterocylcic ligand that is effective, economical, and provides improvements in oxidative stability in the one step synthesis of 1,3-propanediol (1,3-PDO) from ethylene oxide and synthesis gas. For example, cobalt-ruthenium-2,2′-bipyrimidine, 2,2′-dipyridyl, or 2,4,6-tripridyl-s-triazine catalyst precursors in cyclic ether solvents, such as 1,3-dioxolane, 1,4-dioxolane, 1,4-dioxane, and 2-ethyl-2-methyl-1,3-dioxolane, provide good yields of 1,3-PDO in a one step synthesis.
参考文献:10.3390/ijms12063723 摘要:Arimura G, Ozawa R, Maffei ME. Recent advances in plant early signaling in response to herbivory. Int J Mol Sci. 2011;12(6):3723–39. 参考文献:10.3390/ijms12063831 摘要:Miao S, Shi X, Zhang H, Wang S, Sun J, Hua W, Miao Q, Zhao Y, Zhang C. Proliferation-attenuating and apoptosis-inducing effects of tryptanthrin on human chronic myeloid leukemia K562 cell line in vitro. Int J Mol Sci. 2011;12(6):3831–45. 参考文献:10.1371/journal.pbio.1001099 摘要:Wu G, Liu N, Rittelmeyer I, Sharma AD, Sgodda M, Zaehres H, Bleidißel M, Greber B, Gentile L, Han DW, Rudolph C, Steinemann D, Schambach A, Ott M, Schöler HR, Cantz T. Generation of Healthy Mice from Gene-Corrected Disease-Specific Induced Pluripotent Stem Cells. PLoS Biol. 2011 Jul 12;9(7):e1001099. doi: 10.1371/journal.pbio.1001099. 参考文献:10.3797/scipharm.1011-08 摘要:Naseri Z, Hakimi A, Jalilian AR, Nemati Kharat A, Bahrami-Samani A, Ghannadi-Maragheh M. Preparation and quality control of the [sm]-samarium maltolate complex as a lanthanide mobilization product in rats. Sci Pharm. 2011 Apr;79(2):265–75. 参考文献:10.1002/bmc.1671 摘要:Ikeda A, Nishiumi S, Shinohara M, Yoshie T, Hatano N, Okuno T, Bamba T, Fukusaki E, Takenawa T, Azuma T, Yoshida M. Serum metabolomics as a novel diagnostic approach for gastrointestinal cancer. Biomed Chromatogr. 2012 May;26(5):548–58. doi: 10.1002/bmc.1671.