2,6-二硝基甲苯置于ammonium Sulfide体系中,化学反应 0.0H,反应生成 2-氟-6-硝基甲苯 参考文献:Evidences For The Direct Field Effect. Ii.1 The Alkaline Rearrangement Of Fluorosubstituted α-Diketones2 标题:Evidences For The Direct Field Effect. Ii.1 The Alkaline Rearrangement Of Fluorosubstituted α-Diketones2 摘要: DOI:10.1021/ja01486A022
专利号:US-5763599-A 优先权日:1994-12-16 标题:Nucleoside derivatives with photolabile protective groups 发明人:PFLEIDERER WOLFGANG; GIEGRICH HEINER 权利人:PFLEIDERER WOLFGANG 摘要:The invention relates to nucleoside derivatives having photolabile protective groups of the general formula (I) ##STR1## in which R 1 â•?H, NO 2 , CN, OCH 3 , halogen or alkyl or alkoxyalkyl having 1 to 4 C atoms n R 2 â•?H, OCH 3 n R 3 â•?H, F, Cl, Br, NO 2 n R 4 â•?H, halogen, OCH 3 , or an alkyl radical having 1 to 4 C atoms n R 5 â•?H or a usual functional group for preparing oligonucleotides n R 6 â•?H, OH, halogen or XR 8 , where Xâ•?O or S and R 8 represents a protective group usual in nucleotide chemistry, n B=adenine, cytosine, guanine, thymine, uracil, 2,6-diaminopurin-9-yl, hypoxanthin-9-yl, 5-methylcytosin-1-yl, 5-amino-4-imidazolcarboxamid-1-yl, or 5-amino-4-imidazolcarboxamid-3-yl, where in the case of B=adenine, cytosine or guanine, the primary amino function optionally exhibits a permanent protective group. n These derivatives may be used for the light-controlled synthesis of oligonucleotides on a DNA chip.
专利号:EP-1465880-B1 优先权日:2001-11-28 标题 :5-sulphanyl-4h-1,2,4-triazole derivatives and their use to treat disorders associated with somatostatine 发明人:GALCERA CONTOUR MARIE-ODILE; SIDHU ALBAN; ROUBERT PIERRE; THURIEAU CHRISTOPHE 权利人:IPSEN PHARMA 摘要:The invention concerns novel 5-sulphanyl-4H-1,2,4-triazole derivatives of formula (I), wherein: R1, R2 and R3 represent variable groups and the methods for preparing them by liquid-phase parallel synthesis processes. Said product exhibit good affinity for certain sub-types of somatostatin receptors; they are particularly useful for treating pathological conditions or diseases wherein one (or more) somatostatin receptors is (are) involved. The invention also concerns pharmaceutical compositions containing said products and their use for preparing a medicine.
参考标题:New Synthetic Technology For The Construction Of N-Hydroxyindoles And Synthesis Of Nocathiacin I Model Systems 作者:K.C. Nicolaou,Anthony A. Estrada,Graeme C. Freestone,Sang Hyup Lee,Xavier Alvarez-Mico |发布日期:2007.7 摘要:Nucleophilic Additions To In Situ Generated Alpha,Beta-Unsaturated Nitrones (III) Through Carbon-Carbon And Carbon-Heteroatom Bond Formation. The New Synthetic Technology Was Applied To The Synthesis Of Nocathiacin I (1) Model Systems (2 And 3A-C) Containing The N-Hydroxyindole Structural Motif.
合成参考文献
摘要:Aitken, K. M.; Aitken, R. A., Science of Synthesis, (2007) 31, 1234.