合成目标产物 Clomazone 主要起始原料 2-Chlorobenzyl Chloride And 4,4-Dimethyl Isoxazolidin-3-One
81778-07-6 + 611-19-8 = 81777-89-1 反应条件:1.1 Catalysts: 1-Butanaminium,N,N,N-Triethyl-,Chloride (1:1) Solvents: Ethanol,Water; Rt -> 85 °C1.2 8 H,85 °C; 4 H,85 °C 标题:Improvement Method For Synthesis Of 2-(2-Chlorophenylmethyl)-4,4-Dimethyl-3-Isoxazolidinone 作者:Li,Chengfan; Et Al 参考文献:Yanbian Daxue Xuebao 日期:2004 卷标:30(4) 页码:270-273]
81778-06-5 + 611-19-8 = 81777-89-1 [标题:Reaction Conditions 标题:A Process For The Preparation Of 2-[(2-Chlorophenyl)Methyl]-4,4-Dimethyl-3-Isoxazolidinone 参考文献:Japan]
专利号:WO-2024256370-A1 优先权日:2023-06-13 标 题 :Synthesis of glufosinate using an amidase-based process 发明人:ZIMMERMANN GUNTHER; POTT MORITZ STEFAN 权利人:BASF SE 摘要:The present invention relates to a method of preparing glufosinate, comprising the steps of hydrolysing an N-carbamoyl glufosinate amide with an Amidase enzyme to form an N- carbamoyl amino acid compound followed by cleaving off the carbamoyl moiety of said N- carbamoyl amino acid compound.
专利号:US-2025120400-A1 优先权日:2021-12-10 标题:Synthesis of glufosinate using a hydantoinase-based process 发明人:DITRICH KLAUS; BREUER MICHAEL; POTT MORITZ STEFAN; ZIMMERMANN GUNTHER; SEEMAYER STEFAN 权利人:BASF SE 摘要:The present invention relates to a method of manufacturing glufosinate, comprising the steps of hydrolysing a hydantoin with a Hydantoinase enzyme to form a N-carbamoyl amino acid compound followed by cleaving off the carbamoyl moiety of said N-carbamoyl amino acid compound.
专利号:WO-2021143617-A1 优先权日:2020-01-16 标题 :Cyclohexadiene oxime ether compound, synthesis method therefor and application thereof 发明人:DENG ZHAOXI; Hu Hewei; GUO SHAOXIONG; CEN JIN; TAN BIN; DU BINGBING; YANG LINA; LI JUNPEI 权利人:ZHENGZHOU INSTITUTE OF CHIRAL DRUGS RES CO LTD 摘要:The present invention provides a cyclohexadiene oxime ether compound having the following structural formula: (I) or (II) or (III); group R 1 and group R 3 are each selected from -H, an aliphatic substituent containing 1-6 carbon atoms, a halogenated aliphatic substituent, a cyano-substituted aliphatic substituent, amino or amide, phenyl, and a halogenated aromatic substituent or a cyano-substituted aromatic substituent; group R 2 is selected from -H, an aliphatic substituent containing 1-6 carbon atoms, a halogenated aliphatic substituent, a cyano-substituted aliphatic substituent, amino or amide, phenyl, a halogenated aromatic substituent, and a cyano-substituted aromatic substituent, a nitro-substituted aromatic substituent or a heterocyclic aromatic substituent; and the heterocyclic aromatic substituent is selected from (iv), (v) or (vi), wherein X is selected from -H, halogen, -CN, -NO 2 , and -CF 3 , -C(CF 3 ) 3 , and n is the number of substituents and is selected from 1, 2, and 3. The present invention also provides a preparation method for the above-mentioned cyclohexadiene oxime ether compound and an application thereof.
专利号:US-11919928-B2 优先权日:2016-03-16 标题 :Method for producing dihydrotentoxin 发明人:KUBO TAKASHI; MACHIDA MASAYUKI; FUJIOKA TOMONORI; YAMAGUCHI Shigenari; KAWAI KIYOSHI 权利人:KUMIAI CHEMICAL INDUSTRY CO 摘要:An object of the present invention is to identify an enzyme having activity of synthesizing dihydrotentoxin that is a tentoxin precursor and an enzyme having activity of synthesizing tentoxin using dihydrotentoxin as a substrate. The present invention concerns a tentoxin synthesis-related gene encoding a protein comprising the amino acid sequence of SEQ ID NO: 16 and having activity of nonribosomal peptide synthesis of dihydrotentoxin and a tentoxin synthesis-related gene encoding a protein comprising the amino acid sequence of SEQ ID NO: 18 and having activity of converting dihydrotentoxin to tentoxin.
专利号:US-2021386068-A1 优先权日:2018-11-07 标题 :Compositions comprising pyridine carboxylate herbicides and very long chain fatty acid (vlcfa) synthesis inhibitor herbicides 发明人:KISTER JEREMY; SATCHIVI NORBERT M 权利人:CORTEVA AGRISCIENCE LLC 摘要:Disclosed herein are compositions comprising (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a VLCFA synthesis inhibitor herbicide. Also disclosed herein are methods of controlling undesirable vegetation, comprising applying to vegetation or an area adjacent the vegetation or applying in soil or water to control the emergence or growth of vegetation (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof, and (b) a VLCFA synthesis inhibitor herbicide.
专利号:US-2021352899-A1 优先权日:2018-11-07 标题 :Compositions comprising pyridine carboxylate herbicides and fatty acid and lipid synthesis inhibitor herbicides 发明人:KISTER JEREMY; SATCHIVI NORBERT M 权利人:CORTEVA AGRISCIENCE LLC 摘要:Disclosed herein are compositions comprising (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a fatty acid and lipid synthesis inhibitor (FA/LSI) herbicide, an agriculturally acceptable salt or ester thereof, or mixtures thereof. Also disclosed herein are methods of controlling undesirable vegetation, comprising applying to vegetation or an area adjacent the vegetation or applying in soil or water to control the emergence or growth of vegetation (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a fatty acid and lipid synthesis inhibitor (FA/LSI) herbicide, an agriculturally acceptable salt or ester thereof, or mixtures thereof.
1: Van Scoy AR, Tjeerdema RS. Environmental fate and toxicology of clomazone. Rev Environ Contam Toxicol. 2014;229:35-49. doi: 10.1007/978-3-319-03777-6_3. Review. doi: 10.1007/s00128-015-1649-7. Epub 2015 Sep 14. doi: 10.1016/j.jplph.2014.11.009. Epub 2014 Dec 12. doi: 10.1007/s00128-014-1229-2. Epub 2014 Feb 23. doi: 10.1371/journal.pone.0112271. eCollection 2014. 6: Darwish M, Lopez-Lauri F, El Maataoui M, Urban L, Sallanon H. Pretreatment with alternation of light/dark periods improves the tolerance of tobacco (Nicotiana tabacum) to clomazone herbicide. J Photochem Photobiol B. 2014 May 5;134:49-56. doi: 10.1016/j.jphotobiol.2014.03.013. Epub 2014 Mar 29. doi: 10.1021/jf304692c. Epub 2013 Mar 6. doi: 10.1016/j.chemosphere.2016.01.076. Epub 2016 Feb 10. doi: 10.1007/s00128-016-1903-7. Epub 2016 Aug 24. 10: Darwish M, Lopez-Lauri F, Vidal V, El Maâtaoui M, Sallanon H. Alternation of light/dark period priming enhances clomazone tolerance by increasing the levels of ascorbate and phenolic compounds and ROS detoxification in tobacco (Nicotiana tabacum L.) plantlets. J Photochem Photobiol B. 2015 Jul;148:9-20. doi: 10.1016/j.jphotobiol.2015.03.017. Epub 2015 Mar 30. doi: 10.1007/s00244-015-0145-8. Epub 2015 Mar 17. doi: 10.1016/j.etap.2013.07.002. Epub 2013 Jul 10. doi: 10.1002/ps.3275. Epub 2012 Mar 28. doi: 10.1016/S1875-5364(13)60058-8. doi: 10.2166/wst.2016.133. doi: 10.1080/03601234.2014.858007. doi: 10.1016/j.chemosphere.2013.05.024. Epub 2013 Jun 15. doi: 10.1104/pp.110.153296. Epub 2010 Mar 5.
合成参考文献
摘要:U.S. Environmental Protection Agency/Office of Prevention, Pesticides, and Toxic Substances. Reigart, J.R., Roberts, J.R. Recognition and Management of Pesticide Poisonings. 5th ed. 1999. EPA Document No. EPA 735-R-98-003, and available in electronic format at: 摘要: 摘要:Franke C et al; Chemosphere 29: 1501-14 (1994) 摘要:epub ahead of print] (2005) 摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198