CAS: 890-38-0; 9-((2R,4S,5R)-4-Hydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-yl)-9H-Purin-6-Ol

• 英文名称9-((2R,4S,5R)-4-Hydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-yl)-9H-Purin-6-Ol
• 中文名称2'-脱氧肌苷
• IUPAC名称9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol
• 其它别名2'-Deoxyinosine; Deoxyinosine; Inosine, 2'-Deoxy-; 9-((2R,4S,5R)-4-Hydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-yl)-9H-Purin-6-Ol; 9-(2-Deoxy-Beta-D-Ribofuranosyl)Hypoxanthine; Delta-Ino; D-Ino; Hn0Rq6Sbwq; 9-(2-Deoxy-Beta-D-Erythro-Pentofurano
• CAS编号890-38-0
• MFCD编号:MFCD00005762
• EINECS号:212-964-1
• FDA UNII编号:HN0RQ6SBWQ
• 分子式:C10H12N4O4
• 分子量:252.23
• 产品CID: 1911804
• 产品分类有机原料→生命科学→核苷&核苷酸→其他保护性核苷

• 相似结构搜索
• 产品信息参考;
• InChIKey: VGONTNSXDCQUGY-RRKCRQDMSA-N
• InChI=1S/C10H12N4O4/c15-2-6-5(16)1-7(18-6)14-4-13-8-9(14)11-3-12-10(8)17/h3-7,15-16H,1-2H2,(H,11,12,17)/t5-,6+,7+/m0/s1…
• 计算化学: 氢键受体数8.0氢键供体数3.0可旋转键数2.0

相似化合物

物理性质

• 熔点250°C
• 沸点681.2°C at 760 mmHg
• 闪点365.8°C
• 密度1.9±0.1 g/cm3
• PH:21 º (c=1, H2O 22 °C)
• pKa:8.92±0.70(预测)
• PSA:113.52
• LogP:-0.8274
• 旋光度21º(C=1,H2O22ºC)
• 折射率1.837
• 蒸汽压0.0±1.9 mmHg at 25°C
• 溶解性DMSO (Slightly), Water (Slightly)
• 敏感性常温常压下稳定，避免氧化物 接触
• 外观形态白色至类白色粉末
• 储存条件-20°C
• 产品应用该化合物用于高性能液色谱分析的标准.

MSDS等安全信息

• GHS符号GHS07
• 警示词Warning
• 危险描述H302-H315-H319-H335
• 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
• UN编号NONH for all modes of transport
• 危险品标志Xn,Xi
• 安全声明24/25-37/39-36-26
• 危险类别码20/21/22-36/37/38
• WGK Germany3

上下游产品

合成工艺路线路线简述

• 951-78-0 + 68-94-0 = 890-38-0
  反应条件:1.1 Reagents: Potassium Carbonate,Monopotassium Phosphate Solvents: Water; Ph 10,45 °C1.2 Reagents: Sodium Hydroxide Solvents: Water; Ph 10,45 °C1.3 Catalysts: Purine Nucleoside Phosphorylase (Immobilized Onto Glyoxal Agarose Gel),Uridine Phosphorylase (Immobilized Onto Sepabeads Coated With Polyethyleneamine Followed By Crosslinking With Aldehyde-Dextran); 24 H,45 °C
  标题:Synthesis Of 2'-Deoxynucleosides By Transglycosylation With New Immobilized And Stabilized Uridine Phosphorylase And Purine Nucleoside Phosphorylase
  作者:Ubiali,Daniela; Rocchietti,Silvia; Scaramozzino,Francesca; Terreni,Marco; Albertini,Alessandra M.; Et Al
  参考文献:Advanced Synthesis & Catalysis 日期:2004 卷标:346(11) 页码:1361-1366]
  
  68-94-0 + 50-89-5 = 890-38-0
  反应条件:1.1 Solvents: Water; 2 H,Ph 7,45 °C
  标题:Immobilized Escherichia Coli Bl21 As A Catalyst For The Synthesis Of Adenine And Hypoxanthine Nucleosides
  作者:Trelles,Jorge A.; Bentancor,Leticia; Schoijet,Alejandra; Porro,Silvia; Lewkowicz,Elizabeth S.; Et Al
  参考文献:Chemistry & Biodiversity 日期:2004 卷标:1(2) 页码:280-288]
  
  68-94-0 + 50-89-5 = 890-38-0
  反应条件:1.1 Solvents: Water; Ph 7,45 °C
  标题:Microbial Synthesis Of Antiviral Nucleosides Using Escherichia Coli Bl21 As Biocatalyst
  作者:Rogert,Maria C.; Trelles,Jorge A.; Porro,Silvia; Lewkowicz,Elizabeth S.; Iribarren,Adolfo M.
  参考文献:Biocatalysis And Biotransformation 日期:2002 卷标:20(5) 页码:347-351]
  
  = 890-38-0
  反应条件:1.1 Reagents: Triethylamine Trihydrofluoride Solvents: Tetrahydrofuran
  标题:A Convenient Procedure For The Deprotection Of Silylated Nucleosides And Nucleotides Using Triethylamine Trihydrofluoride
  作者:Pirrung,Michael C.; Shuey,Steven W.; Lever,David C.; Fallon,Lara
  参考文献:Bioorganic & Medicinal Chemistry Letters 日期:1994 卷标:4(11) 页码:1345-6]
  
  958-09-8 = 890-38-0
  反应条件:1.1 Catalysts: Adenosine Deaminase; 2 H
  标题:Coupled Biocatalysts Applied To The Synthesis Of Nucleosides
  作者:Medici,Rosario; Porro,Marisa Taverna; Lewkowicz,Elizabeth; Montserrat,Javier; Iribarren,Adolfo M.
  参考文献:Nucleic Acids Symposium Series 日期:2008 卷标:52(1) 页码:541-542]
  
  951-78-0 + 68-94-0 = 890-38-0
  反应条件:1.1 Catalysts: Nucleoside Deoxyribosyltransferase Solvents: Water; 1 H,Ph 7,65 °C
  标题:Thermus Thermophilus Strains Active In Purine Nucleoside Synthesis
  作者:Almendros,Marcos; Gago,Jose-Vincente Sinisterra; Carlos,Jose Berenguer
  参考文献:Molecules 日期:2009 卷标:14(3) 页码:1279-1287]
  
  958-09-8 = 890-38-0 [标题:Reaction Conditions
  标题:Development Of An Endonuclease V-Assisted Analytical Method For Sequencing Analysis Of Deoxyinosine In Dna
  作者:Zheng,Xiaofang; Chen,Di; Zhao,Yingqi; Dai,Xiaoxia; You,Changjun
  参考文献:Analytical Chemistry (Washington 日期:2022 卷标:94(33) 页码:11627-11632]
  
  951-78-0 + 68-94-0 = 890-38-0
  反应条件:1.1 Catalysts: Nucleoside Deoxyribosyltransferase Solvents: Water; 2 H,Ph 6.5,40 °C
  标题:Enzymatic Synthesis Of Nucleoside Analogues Using Immobilized 2'-Deoxyribosyltransferase From Lactobacillus Reuteri
  作者:Fernandez-Lucas,Jesus; Fresco-Taboada,Alba; Acebal,Carmen; Mata,Isabel; Arroyo,Miguel
  参考文献:Applied Microbiology And Biotechnology 日期:2011 卷标:91(2) 页码:317-327]
  
  68-94-0 = 890-38-0
  反应条件:1.1 Reagents: Monopotassium Phosphate Catalysts: Purine Nucleoside Phosphorylase,Thymidine Phosphorylase Solvents: Water; 5 Min,20 °C; 20 H,20 °C
  标题:Use Of Nucleoside Phosphorylases For The Preparation Of Purine And Pyrimidine 2'-Deoxynucleosides
  作者:Drenichev,Mikhail S.; Alexeev,Cyril S.; Kurochkin,Nikolay N.; Mikhailov,Sergey N.
  参考文献:Advanced Synthesis & Catalysis 日期:2018 卷标:360(2) 页码:305-312]
  
  958-09-8 = 890-38-0
  反应条件:1.1 Catalysts: Adenosine Deaminase
  标题:Nucleic Acid-Related Compounds. 8. Direct Conversion Of 2'-Deoxyinosine To 9-(2-Deoxy-β-D-Erythro-Pentofuranosyl)-6-Chloropurine And Selected 6-Substituted Deoxynucleosides And Their Evaluation As Substrates Of Adenosine Deaminase
  作者:Robins,Morris J.; Basom,Gerald L.
  参考文献:Canadian Journal Of Chemistry 日期:1973 卷标:51(19) 页码:3161-9]
  
  = 890-38-0 [标题:Reaction Conditions
  标题:A New Strategy For The Protection Of Deoxyguanosine During Oligonucleotide Synthesis
  作者:Gaffney,B. L.; Jones,R. A.
  参考文献:Tetrahedron Letters 日期:1982 卷标:23(22) 页码:2257-60]
  
  68-94-0 + 50-89-5 = 890-38-0
  反应条件:1.1 Reagents: Dipotassium Phosphate,Monopotassium Phosphate Solvents: Water; 24 H,Ph 7,60 °C
  标题:Screening Of Catalytically Active Microorganisms For The Synthesis Of 6-Modified Purine Nucleosides
  作者:Trelles,J. A.; Valino,A. L.; Runza,V.; Lewkowicz,E. S.; Iribarren,A. M.
  参考文献:Biotechnology Letters 日期:2005 卷标:27(11) 页码:759-763]
  
  958-09-8 = 890-38-0
  反应条件:1.1 Catalysts: Adenosine Deaminase Solvents: Water; 2 H,Ph 7,37 °C
  标题:Arthrobacter Oxydans As A Biocatalyst For Purine Deamination
  作者:Medici,Rosario; Lewkowicz,Elizabeth S.; Iribarren,Adolfo M.
  参考文献:Fems Microbiology Letters 日期:2008 卷标:289(1) 页码:20-26]
  
  951-78-0 + 68-94-0 = 890-38-0
  反应条件:1.1 Catalysts: Nucleoside Deoxyribosyltransferase; 60 Min,Ph 7,57 °C
  标题:Synthesis Of 2'-Deoxyibosylnucleosides Using New 2'-Deoxyribosyltransferase Microorganism Producers
  作者:Fernandez-Lucas,J.; Condezo,L. A.; Martinez-Lagos,F.; Sinisterra,J. V.
  参考文献:Enzyme And Microbial Technology 日期:2007 卷标:40(5) 页码:1147-1155]
  
  68-94-0 + 50-89-5 = 890-38-0
  反应条件:1.1 Solvents: Water; 4 H,Ph 7,60 °C
  标题:Aeromonas Hydrophila Strains As Biocatalysts For Transglycosylation
  作者:Nobile,Matias; Terreni,Marco; Lewkowicz,Elizabeth; Iribarren,Adolfo M.
  参考文献:Biocatalysis And Biotransformation 日期:2011 卷标:28(5-6) 页码:395-402]
  
  951-78-0 + 68-94-0 = 890-38-0
  反应条件:1.1 Catalysts: Uridine Phosphorylase1.2 Catalysts: Purine Phosphorylase,Family 2 ( 5′-Methylthioadenosine Phosphorylase) (Methanog...1.3 -
  标题:Correlation Between Yield And Reduced Mass Of Raw Materials In Enzymatic Reactions
  作者:Kawashima,Masatoshi
  参考文献:Chemrxiv 日期:2021 卷标:1 页码:1-4]
  
  68-94-0 + 50-89-5 = 890-38-0
  反应条件:1.1 Catalysts: Purine Nucleoside Phosphorylase,Thymidine Phosphorylase Solvents: Water; 2 H,Ph 7,50 °C
  标题:Enzymatic Synthesis Of Nucleosides By Nucleoside Phosphorylase Co-Expressed In Escherichia Coli
  作者:Ding,Qing-Bao; Ou,Ling; Wei,Dong-Zhi; Wei,Xiao-Kun; Xu,Yan-Mei; Et Al
  参考文献:Journal Of Zhejiang University 日期:2010 卷标:11(11) 页码:880-888]
  
  68-94-0 + 50-69-1 = 890-38-0
  反应条件:1.1 Reagents: 5′-Atp,Potassium Chloride,Manganese Dichloride Catalysts: Ribokinase Solvents: Water; Ph 7.5,20 °C1.2 Catalysts: Phosphoribomutase; 24 H,Ph 7.5
  标题:A New Strategy For The Synthesis Of Nucleosides: One-Pot Enzymatic Transformation Of D-Pentoses Into Nucleosides
  作者:Miroshnikov,Anatoly I.; Esipov,Roman S.; Muravyova,Tat'Yana I.; Konstantinova,Irina D.; Fateev,Ilja V.; Et Al
  参考文献:Open Conference Proceedings Journal 日期:2010 卷标:1 页码:98-102]
  
  68-94-0 + 50-89-5 = 890-38-0
  反应条件:1.1 Catalysts: Purine Nucleoside Phosphorylase,Thymidine Phosphorylase Solvents: Water; 3 H,Ph 7.4,25 °C
  标题:High-Yielding Cascade Enzymatic Synthesis Of 5-Methyluridine Using A Novel Combination Of Nucleoside Phosphorylases
  作者:Visser,Daniel F.; Rashamuse,Konanani J.; Hennessy,Fritha; Gordon,Gregory E. R.; Van Zyl,Petrus J.; Et Al
  参考文献:Biocatalysis And Biotransformation 日期:2010 卷标:28(4) 页码:245-253

海关参考信息

• 2905122000-异丙醇
  2905310000-1,2-乙二醇
  2905320000-1,2-丙二醇
  2905399001-1,3-丙二醇
• 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
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