CAS: 89151-44-0; N-Boc-4-Piperidineethanol

相似化合物

622-26-4 21156-84-3 509147-79-9

上下游产品

CAS号622-26-4 4-哌啶乙醇 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号135716-09-5 1-B°C-4-哌啶乙酸乙酯 | CAS号34619-03-9 碳酸二叔丁酯 | CAS号157688-46-5 1-叔丁氧羰基-4-哌啶乙酸 | CAS号28356-58-3 4-吡啶乙酸 | CAS号79099-07-3 1-B°C-4-哌啶酮 | CAS号135716-08-4 2-(1-B°C-4-亚哌啶基)乙酸乙酯 | CAS号13292-87-0 硼烷二甲硫醚 | CAS号6622-91-9 4-吡啶乙酸盐酸盐 | CAS号142355-80-4 1-B°C-4-(4-甲氧基-... | CAS号147699-19-2 1-N-B°C-O-甲磺酰－羟乙基哌啶 | CAS号301221-63-6 4-(1-溴-2-氧代乙基)哌... | CAS号89151-45-1 1-B°C-4-[2-(甲苯-... | CAS号142355-81-5 1-B°C-4-(4-溴丁基)-哌啶 | CAS号142374-19-4 4-(2-氧代乙基)哌啶-1-羧酸叔丁酯 | CAS号142355-83-7 4-(1-B°C-4-哌啶基)-1-丁醇 | CAS号347873-67-0 4-(2-苯氧基乙基)哌啶 | CAS号142247-38-9 N-B°C-4-哌啶丁酸 | CAS号146093-46-1 2-(N-B°C-4-哌啶基)乙胺

1-Boc-4-哌啶甲酸乙酯置于lithium Aluminium Tetrahydride体系中,用 四氢呋喃 作为反应溶剂,化学反应生成 N-Boc-4-哌啶乙醇
参考文献:具有(2R)-2-[((1R)-3,3-二氟环戊基]-2-羟基苯基乙酰胺结构的毒蕈碱m(3)受体拮抗剂.第2部分.
标题:具有(2R)-2-[((1R)-3,3-二氟环戊基]-2-羟基苯基乙酰胺结构的毒蕈碱m(3)受体拮抗剂.第2部分.
摘要:进行了我们原始毒蕈碱型m(3)受体拮抗剂1的胺部分的优化,以鉴定出优于1的m(3)受体拮抗剂.对氮原子上带有疏水取代基的各种二胺部分的化合物进行了筛选. M(3)受体的结合亲和力和m(3)超过m(1)和m(2)受体的选择性.该过程导致了4-氨基哌啶酰胺(2L),其k(i)值为5.1 Nm,M(3)受体的选择性比m(2)受体大46倍.通过插入间隔基或将烷基引入胺部分进一步2L衍生化,从而鉴定出k(i)值为3的4-(氨基乙基)哌啶酰胺2L-B.
DOI:10.1016/s0960-894X(03)00350-0

专利信息

专利号:US-12441733-B2
优先权日:2018-03-26
标题:Substituted 2,4-dioxotetrahydropyrimidines as intermediates in the synthesis of bruton's tyrosine kinase inhibitors
发明人：ARISTA LUCA; HEBACH CHRISTINA; HOLLINGWORTH GREGORY JOHN; HOLZER PHILIPP; IMBACH-WEESE PATRICIA; LORBER JULIEN; MACHAUER RAINER; SCHMIEDEBERG NIKO; VULPETTI ANNA; ZOLLER THOMAS
权利人:NOVARTIS AG
摘要:The invention relates to compounds of the formulae (I), (III), (IIIa), (XXIa), (XXIII), and/or (XLVI)or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.

专利号:US-7645754-B2
优先权日:2001-12-20
标题 :Pyrrolopyrimidine A2B selective antagonist compounds, their synthesis and use
发明人：CASTELHANO ARLINDO; MCKIBBEN BRYAN; STEINIG ARNO
权利人:OSI PHARM INC
摘要:The subject invention provides compounds having the structure: n n n n n n n n n n n n wherein,n R 1 is a substituted or unsubstituted alkyl, wherein the substituent is hydroxyl, dihydroxy, carboxyl, —C(â•?O)NR a R b , —NR a R b , —NR a C(â•?O)NR a R b , —NR a C(â•?O)OR a , —OC(â•?O)NR a R b , or —NHC(â•?O) R a ; R 2 is hydrogen or a substituted or unsubstituted alkyl, wherein the substituent is hydroxyl, dihydroxy, carboxyl, —C(â•?O)NR a R b , —NR a R b , —NR a C(â•?O)NR a R b , —NR a C(â•?O)OR a , —OC(â•?O)NR a R b , or —NHC(â•?O)R a , or R 1 , R 2 and N together form a substituted piperazine, substituted azetidine ring, or a pyrrolidine ring substituted with —(CH 2 ) 2 OH or —CH 2 C(â•?O)OH; R 3 is a substituted or unsubstituted phenyl or a 5-6 membered heteroaryl ring, wherein the substituent is halogen, hydroxyl, cyano, (C 1 -C 15 )alkyl, (C 1 -C 15 )alkoxy, or —NR a R b ; R 4 is hydrogen or substituted or unsubstituted (C 1 -C 15 )alkyl; R 5 is —(CH 2 ) m OR 6 , —CHNOR 7 , —C(â•?O)NR 8 R 9 , —(CH 2 ) m C(â•?O)OR 10 , —(CH 2 ) k C(â•?O)NR 11 R 12 ;n wherein R 6 is a substituted or unsubstituted (C 1 -C 30 )alkyl, (C 3 -C 10 )cycloalkyl, or an aryl, heteroaryl or 4-8 membered heterocyclic ring; R 7 is hydrogen, or a substituted or unsubstituted (C 1 -C 30 )alkyl, (C 1 -C 30 )alkylaryl; R 8 and R 9 are each independently hydrogen, or a substituted or unsubstituted (C 1 -C 30 )alkyl, (C 1 -C 30 )alkylaryl, (C 1 -C 30 )alkylamino, (C 1 -C 30 )alkoxy, or a saturated or unsaturated, monocyclic or bicyclic, carbocyclic or heterocyclic ring, or R 8 , N, and R 9 together form a substituted or unsubstituted 4-8 membered heterocyclic ring; R 10 is hydrogen or a substituted or unsubstituted (C 1 -C 30 )alkyl, (C 3 -C 10 )cycloalkyl, or an aryl, heteroaryl or heterocyclic ring; R 11 , N and R 12 together form a 4-8 membered heterocyclic ring; R a and R b are each independently hydrogen or alkyl; m is 0, 1, 2 or 3; and k is 1, 2 or 3,n nor a specific enantiomer thereof, or a specific tautomer thereof, or a pharmaceutically acceptable salt thereof, and a method for treating a disease associated with the A 2b adenosine receptor in a sbject in need of such treatment comprising administering to the subject a therapeutically effective amount of the compounds of the invention.

专利号:US-9708336-B2
优先权日:2014-01-22
标题 :Metallo-beta-lactamase inhibitors
发明人：MANDAL MIHIR; TANG HAIFENG; XIAO LI; SU JING; LI GUOQING; YANG SHU-WEI; PAN WEIDONG; TANG HAIQUN; DEJESUS REYNALDA; HICKS JACQUELINE; LOMBARDO MATTHEW; CHU HONG; HAGMANN WILLIAM; PASTERNAK ALEX; GU XIN; JIANG JINLONG; DONG SHUZHI; DING FA-XIANG; LONDON CLARE; BISWAS DIPSHIKHA; YOUNG KATHERINE; HUNTER DAVID N; ZHAO ZHIQIANG; YANG DEXI
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.

专利号:US-10399992-B2
优先权日:2016-04-11
标题:Process for preparing AD-35
发明人：ZHONG JINQING; ZHAO XUYANG; BAI HUA; GONG YONGXIANG; ZHANG XINLONG; ZHU QIFENG; LIU WEIWEI; ZHOU YA
权利人:ZHEJIANG HISUN PHARM CO LTD
摘要:Disclosed are a method for preparing a benzodioxole derivative (AD-35) shown by Formula (I) and an intermediate thereof. The method of the present invention involves: using piperic acid as a raw material; and performing bromination, esterification, cyanidation, cyclopropane lactamization, amide nitrogen alkylation, deprotection, piperidine nitrogen alkylation and salification to obtain the compound of Formula (I). The method has cheap and easily available start raw materials, short synthesis routes and simple operation, and is suitable for industrial production.

专利号:MX-PA04005861-A
优先权日:2001-12-20
标题:SELECTIVE ANTAGONIST COMPOUNDS OF PIRROLOPIRIMIDINA A2B, ITS SYNTHESIS AND USE.

专利号:CN-116693417-B
优先权日:2023-05-09
标题:Synthesis method of oxime compound