CAS: 104-85-8; P-Tolunitrile

上下游产品

CAS号3235-02-7 4-甲基苯甲醛肟 | CAS号106-38-7 对溴甲苯 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号624-31-7 对碘甲苯 | CAS号104-84-7 4-甲基苄胺 | CAS号1158998-82-3 4-methyl-N,N-di... | CAS号13107-39-6 4-vinyltoluene oxide | CAS号589-18-4 4-甲基苄醇 | CAS号14062-78-3 N,N-二甲基-4-甲基苯甲酰胺 | CAS号122334-36-5 N-甲氧基-N,4-二甲基苯甲酰胺 | CAS号10532-64-6 (4-methylphenyl... | CAS号55805-10-2 4-(二氟甲氧基)苯甲腈 | CAS号34490-85-2 1-(4-(氨基甲基)苯基)-... | CAS号3816-66-8 3-羟基-4-甲基苯腈 | CAS号42872-74-2 3-溴-4-甲基苯甲腈 | CAS号52798-01-3 2-(4-氰基苯基)乙酸甲酯 | CAS号50737-29-6 5-(Chloromethyl... | CAS号42872-73-1 2-溴-4-甲基苄腈 | CAS号60710-80-7 3-氨基-4-甲基苯腈 | CAS号5337-93-9 对甲基苯丙酮

对三氟甲基苯腈置于n-Bu4Bf4体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应生成对甲苯腈
参考文献:离子自由基中键断裂的动力学.氟甲基芳烃碳氟键还原裂解的机理和反应性
标题:离子自由基中键断裂的动力学.氟甲基芳烃碳氟键还原裂解的机理和反应性
摘要:在液氨和 Dmf 中,通过循环伏安法和/或氧化还原催化,研究了氟甲基芳烃中碳-氟键的还原裂解机制和反应性,作为氟原子数量和芳基结构的函数部分.三氟化合物的还原,最终导致完全脱氟,涉及作为中间体的二氟和单氟衍生物.卡宾不沿反应途径蒸腾.分子内解离电子转移模型的应用允许在驱动力和内在势垒方面定量合理化初级阴离子自由基的裂解反应性随氟原子数的变化以及芳基部分的结构与介质的溶剂化特性一样.
Doi:10.1021/ja971094O

专利信息

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:US-2006287520-A1
优先权日:2005-05-16
标 题 :Synthesis of salinosporamide A and analogues thereof
发明人：DANISHEFSKY SAMUEL J; ENDO ATSUSHI
权利人:DANISHEFSKY SAMUEL J; ENDO ATSUSHI
摘要:A novel synthesis of salinosporamide A is provided. Salinospoamide A as well as structurally related natural products, omuralide and lactacystin, have been shown to be proteasome inhibitors. Therefore, these compounds as well as analogues of these natural products may be useful in the treatment of proliferative diseases such as cancer, autoimmune diseases, diabetic retinopathy, etc. The invention provides for the synthesis of salinosporamide A as well as analogs thereof using a convenient point for derivatization of the bicyclic core. Pharmaceutical compositions and method of using the inventive compounds are also provided.

专利号:US-11542269-B2
优先权日:2018-01-03
标 题:Prins reaction and compounds useful in the synthesis of halichondrin macrolides and analogs thereof
发明人：CHOI HYEONG-WOOK; FANG FRANCIS G
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods utilizing Prins reaction in the preparation of compounds that may be useful as intermediates in the synthesis of halichondrin macrolides and analogs thereof. The invention also provides compounds that may be useful as intermediates in the synthesis of a halichondrin macrolides and methods for preparing the same.

专利号:US-7910623-B2
优先权日:2005-07-22
标 题 :Synthesis of scabronines and analogues thereof
发明人：DANISHEFSKY SAMUEL J; WATERS STEPHEN P
权利人:SLOAN KETTERING INST CANCER
摘要:A novel synthesis of scabronines, which are related to a broader class of angularly fused tricyclic diterpenoids known as cyathanes, is provided. Scabronine G, its methyl ester derivative, and other analogs have been shown to have neurotrophic activity. Therefore, these compounds are particularly useful in treating neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's diseases, etc. The invention provides for the synthesis of scabronines as well as analogs thereof. Pharmaceutical compositions and method of using the inventive compounds are also provided.

专利号:WO-2012047907-A9
优先权日:2010-10-04
标题 :Synthesis of c5-substituted tetracyclines, uses thereof, and intermediates thereto
发明人：MYERS ANDREW G; WRIGHT PETER M; HECKER EVAN
权利人:HARVARD COLLEGE; MYERS ANDREW G; WRIGHT PETER M; HECKER EVAN
摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides more efficient routes for preparing the enone intermediate and allows for a wide variety of substituents at position 5 of the tetracycline ring system.

专利号:US-10913749-B2
优先权日:2015-05-07
标 题 :Macrocyclization reactions and intermediates and other fragments useful in the synthesis of halichondrin macrolides
发明人：FANG FRANCIS G; KIM DAE-SHIK; CHOI HYEONG-WOOK; CHASE CHARLES E
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods for the synthesis of a halichondrin macrolides through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Horner-Wadsworth-Emmons olefination), catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides and methods for preparing the same.