CAS: 1072-97-5; 5-Bromopyridin-2-Amine

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CAS号504-29-0 2-氨基吡啶 | CAS号664988-25-4 5-bromo-2-(dibe... | CAS号444811-18-1 5-bromo-N,N-bis... | CAS号39856-50-3 5-溴-2-硝基吡啶 | CAS号157020-26-3 pyridinium N-[2... | CAS号899452-28-9 2(1H)-Pyridinim... | CAS号33245-29-3 5-溴-n-硝基吡啶-2-胺 | CAS号138888-98-9 N'-(5-溴吡啶-2-基)-... | CAS号112357-06-9 N'-(5-Bromo-2-p... | CAS号106730-70-5 4-(dimethylamin... | CAS号33421-40-8 2-氨基-5-苯基吡啶 | CAS号92-52-4 联苯 | CAS号503536-74-1 5-(4-甲基苯基)-2-氨基吡啶 | CAS号381233-96-1 2-氨基-3-碘-5-溴吡啶 | CAS号356560-80-0 6-溴-[1,2,4]三唑并[... | CAS号38185-55-6 2-氨基-3-氯-5-溴吡啶 | CAS号35486-42-1 2-氨基-3,5-二溴吡啶 | CAS号4044-99-9 6-溴-2-甲基咪唑并[1,2-a]吡啶

2-氨基吡啶置于四丁基溴化铵体系中,用 二氯甲烷 用作溶剂,化学反应 5.5H,以37%的收率获得2-氨基-5-溴吡啶
参考文献:使用 N Bu4Nbr 对富电子芳香环进行电化学区域选择性溴化
标题:使用 N Bu4Nbr 对富电子芳香环进行电化学区域选择性溴化
摘要:使用化学计量的四丁基溴化铵 (N Bu4Nbr) 在温和条件下完成了富电子芳环的电化学区域选择性溴化.该协议为构建具有广泛官能团耐受性的中等至高产率的 C-Br 键提供了一种环境友好且简单的方法.
Doi:10.1055/s-0037-1611545

专利信息

专利号:EP-0842924-B1
优先权日:1996-11-14
标 题 :Pyridine intermediates, useful in the synthesis of beta-adrenergic receptor agonists
发明人：WRIGHT STEPHEN WAYNE
权利人:PFIZER
摘要:The present invention relates to certain compounds of the formula (I), which are useful in the synthesis of certain beta -adrenergic receptor agonists. The invention also relates to a process for synthesizing the compounds of formula (I) and to compounds of the formula (II), wherein R<1>, R<2> and R<4> are defined herein, which are useful in the synthesis of the compounds of formula (I). The invention also relates to a process for synthesizing a compound of formula (II). The invention further relates to processes for synthesizing compounds of formula (Z*), R<1>, R<2> and Y<2*> are defined herein.o

专利号:US-4557866-A
优先权日:1984-05-15
标 题 :Process for the synthesis of pyrido-imidazo rifamycins
发明人：CANNATA VINCENZO; TAMAGNONE GIAN F
权利人:ALFA FARMACEUTICI SPA
摘要:A new process for the synthesis of pyrido-imidazo-rifamycins of formula I wherein R is hydrogen or acetyl, R1 and R2 independently represent hydrogen, (C1-4)-alkyl, benzyloxy, mono- or di-(C1-3)-alkylamino-(C1-4)-alkyl, (C1-3)-alkoxy-(C1-4)-alkyl, hydroxymethyl, hydroxy-(C2-4)-alkyl, cyano, halogen, nitro, mercapto, (C1-4)-alkylthio, phenylthio, carbamoyl, mono- or di-(C1-4)-alkyl-carbamoyl, or R1 and R2 taken together with two consecutive carbon atoms of the pyridine nucleus form a benzene ring optionally substituted by one or two methyl or ethyl groups. The process comprises reacting the rifamycin O of formula II with a 2-aminopyridine of formula III wherein R1 and R2 have the same meanings as before.

专利号:US-7884125-B2
优先权日:2008-04-30
标 题:Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues
发明人：STEVENS CHRISTIAN; HEUGEBAERT THOMAS
权利人:UNIV GENT
摘要:The present invention relates to a group of substituted-7-azabicyclo-[2.2.1]heptyl derivatives with biological activity. The present invention also relates to synthetic methods for producing said substituted-7-azabicyclo-[2.2.1]heptyl derivatives. The present invention also relates to certain intermediates for producing such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as a synthetic method for producing such intermediates. The present invention also relates to pharmaceutical compositions comprising such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as their use as medicaments for the treatment of diseases mediated by a Nicotinic Acetylcholine Receptor or a receptor being a member of the Neurotransmitter-gated Ion Channel Superfamily, such as pain, Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy and nicotine addiction.

专利号:US-9695147-B2
优先权日:2013-07-25
标题 :Process for the preparation of perampanel
发明人：BUCHLOVIC MARIAN
权利人:TEVA PHARMACEUTICALS INT GMBH
摘要:The present invention provides intermediates useful for the synthesis of Perampanel and processes employing said intermediates for preparing Perampanel. The invention also provides processes for making the intermediates, crystalline forms of the intermediates and the use of the crystalline forms for preparing Perampanel.

专利号:EP-0332033-A2
优先权日:1988-03-11
标 题:N-cyclopropyl anilines and their use in processes for the synthesis of 1-cyclopropyl-quinolone-carboxylic acids and their derivatives
发明人：SCHRIEWER MICHAEL DR; PETERSEN UWE DR; GROHE KLAUS DR; KREBS ANDREAS DR
权利人:BAYER AG
摘要:N-Cyclopropylanilines of the formula (IV) in which R<1>, X<1>, X<2>, X<3>, A, Z and R<2> have the meaning given in the description, which are suitable for the preparation of 4-quinolone- 3-carboxylic acids, and processes for the preparation of quinolone- carboxylic acid derivatives using N-cyclopropylanilines.

专利号:US-8926801-B2
优先权日:2009-01-16
标题 :Methods of electrospray chemical synthesis and device for use therein
发明人：REHMAN ATIQ
权利人:REHMAN ATIQ; CANAM BIORES INC
摘要:The present invention relates to methods of production of chemical bonds and subsequent molecules by electrospray ionization and the design of an electrospray chemical synthesizer, for use in chemical synthesis and expedited organic chemical reactions.