CAS: 112914-13-3; 2-Aminomethy-4-(4-Fluorobenzyl)Morpholine

相似化合物

110859-47-7 186293-55-0 214273-17-3

上下游产品

2-乙酰氨甲基-4-(4-氟苄基)吗啉 2-<(Acetylamino)Methyl>-4-(4-Fluorobenzyl)Morpholine 112913-94-7
2-(N-Acetylaminomethyl)-4-Benzylmorpholine 112913-96-9
[4-(3,4-Dichlorobenzyl)Morpholin-2-Yl]Methylamine 407640-03-3
2-[4-(4-Fluoro-Benzyl)-Morpholine-2-Yl-Methyl]-Isoindole-1,3-Dion 636582-78-0

<2-(Acetylamino)Methyl>Morpholine Acetyl Salt置于盐酸,Potassium Carbonate,Potassium Iodide体系中,用 丁酮 用作溶剂,化学反应 21.0H,反应生成2-氨甲基-4-(4-氟苄基)吗啉
参考文献:Novel Benzamides As Selective And Potent Gastrokinetic Agents. 2. Synthesis And Structure-Activity Relationships Of 4-Amino-5-Chloro-2-Ethoxy-N-[[4-(4-Fluorobenzyl)-2-Morpholinyl]Methyl]Benzamide Citrate (As-4370) And Related Compounds
标题:Novel Benzamides As Selective And Potent Gastrokinetic Agents. 2. Synthesis And Structure-Activity Relationships Of 4-Amino-5-Chloro-2-Ethoxy-N-[[4-(4-Fluorobenzyl)-2-Morpholinyl]Methyl]Benzamide Citrate (As-4370) And Related Compounds
摘要:The Title Compounds (19-55) With A 4-Substituted 2-(Aminomethyl) Morpholine Group Were Prepared And Evaluated For The Gastrokinetic Activity By Determining Their Effect On Gastric Emptying Of Phenol Red Semisolid Meal In Rats. Introduction Of Chloro,Fluoro,And Trifluoromethyl Groups To The Benzyl Group Of The Parent Compounds 1A And 1B Enhanced The Activity. Among Compounds Tested,4-Amino-5-Chloro-2-Ethoxy-N-[[4-(4-Fluorobenzyl)-2-Morpholinyl] Methyl]Benzamide (23B) Showed The Most Potent Gastic Emptying Activity (Effects On Phenol Red Semisolid Meal In Rats And Mice,And On Resin Pellets Solid Meal In Rats). The Gastrokinetic Activity Of 23B Citrate (As-4370) Compared Very Favorably With That Of Cisapride And Was Higher Than That Of Metoclopramide. In Contrast To Metoclopramide And Cisapride,As-4370 Was Free From Dopamine D2 Receptor Antagonistic Activity In Both In Vitro ([h-3]Spiperone Binding) And In Vivo (Apomorphine-Induced Emesis In Dogs) Tests.
Doi:10.1021/jm00106A023

专利信息

专利号:US-2024051897-A1
优先权日:2022-07-26
标题:Synthesis of complex 15n-labeled molecules
发明人：DORSHEIMER JULIA; ROVIS TOMISLAV
权利人:UNIV COLUMBIA
摘要:Methods for conversion of a broad range of amines to their 15N isotopic counterparts and the compounds produced thereby.

专利号:EP-1515958-A2
优先权日:2002-06-13
标 题:Process for the synthesis of mosapride

专利号:WO-03106440-A2
优先权日:2002-06-13
标题:Process for the synthesis of a benzamide derivative

专利号:CN-118108572-A
优先权日:2024-01-09
标 题:Synthesis method of alkyl trifluoromethyl compounds