CAS: 127199-45-5; (S)-Tert-Butyl 5-Azaspiro[2.4]Heptan-7-Ylcarbamate

相似化合物

127199-44-4 152513-88-7 144282-37-1

上下游产品

CAS号58632-95-4 2-(叔-丁氧基碳酰胺)-2-苯乙腈 | CAS号127199-41-1 7-(S)-amino-5-[... | CAS号127199-38-6 7-(S)-amino-5-[... | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号180506-32-5 (R)-5-benzyl-7-... | CAS号144282-41-7 (S)-7-Amino-5-b... | CAS号129306-04-3 5-苄基-5-氮杂螺[2.4]... | CAS号127254-12-0 西他沙星

1-乙酰基环丙烷羧酸乙酯置于4-二甲氨基吡啶,Lithium Aluminium Tetrahydride,5%-Palladium/activated Carbon,Ammonium Acetate,溴,Ammonium Formate,Sodium Cyanoborohydride,溶剂黄146,三乙胺体系中,用 四氢呋喃,乙醇,二氯甲烷 用作溶剂,化学反应 36.0H,反应生成(7S)-5-氮杂螺[2.4]庚烷-7-基氨基甲酸叔丁酯
参考文献:西他沙星五元环侧链中间体的制备方法
标题:西他沙星五元环侧链中间体的制备方法
摘要:本发明涉及一种西他沙星五元环侧链中间体的制备方法,包括以下步骤:原料1的酮羰基在醋酸铵或氯化铵存在下与氰基硼氢化钠或三醋酸硼氢化钠反应,所得产物的酰胺羰基用四氢铝锂还原,还原产物的游离氨基在碱的存在下与二碳酸二叔丁酯反应,所得产物的苯乙基在钯‑碳的存在下用甲酸或甲酸盐还原脱除,即得所述西他沙星侧链中间体(产物5).该方法反应条件温和,对设备要求低,制备过程安全,立体选择性好,原料试剂廉价易得,制备成本低.

专利信息

专利号:US-7074837-B2
优先权日:2000-08-08
标题 :Processes for preparation of bicyclic compounds and intermediates therefor
发明人：NAKAYAMA KEIJI; MUTO MAKOTO; SAITO TATSURU; TANI YUICHIRO; AKIBA TOSHIFUMI
权利人:DAIICHI SEIYAKU CO
摘要:A process for preparing intermediate compound (VII), compound (VIII) and compound (XIV) which will be raw materials for the synthesis of a synthetic antibactrial compound, via compound (I) or compound (X) and then, compound (II), the compounds each being shown below; and novel compounds useful for the preparation.

专利号:US-10358417-B2
优先权日:2016-05-06
标 题 :Method for preparing efficiently synthetic sitafloxacin intermediate (7S)-5-azaspiro[2.4]heptane-7-yl tert-butyl carbamate
发明人：LAI YINGJIE; YE DABING; LANG FENGRUI; LONG XIANGTIAN
权利人:CHEN STONE GUANGZHOU CO LTD
摘要:The present invention discloses a preparation method for efficient synthesis of sitafloxacin intermediate (7S)-5-azaspiro[2.4]heptane-7-yl-tert-butyl carbamate, comprising the following steps: reacting n nto obtainn n nreactingn n nto obtainn n nreactingn n nto obtainn n nand reactingn n nto obtainn n nIn the present invention, a single compound with a relatively high ee value can be obtained, the unnecessary waste of materials is avoided, the yield is significantly improved, the operation is simple, the industrial scale-up is easy, and the production cost is reduced.

专利号:US-2005113397-A1
优先权日:2002-01-31
标题:Imidazo[1,2-a]pyridine derivative
发明人：TAKEMURA MAKOTO; TAKAHASHI HISASHI; KAWAKAMI KATSUHIRO; TAKESHITA HIROSHI; KIMURA YOUICHI; WATANABE JUN; SUGIMOTO YUICHI; KITAMURA AKIHIRO; NAKAJIMA RYOHEI; KANAI KAZUO; FUJISAWA TETSUNORI
摘要:A compound reprsented by the following formula (I), its salts or nsolvates thereof capable of specifically or selectively expressig an antifungal activity in a broad spectrum based on the novel mechanism thereof of 1,6-β-glucan synthesis inhibition, and an antifungal agent containing any of them.