CAS: 1310584-14-5; [2'-(Amino-?N)[1,1'-Biphenyl]-2-Yl-?C]Chloro[dicyclohexyl[2',4',6'-Tris(1-Methylethyl)[1,1'-Biphenyl]-2-Yl]Phosphine]Palladium

Palladium Diacetate,2-氨基联苯,Lithium Chloride,2-二环己基磷-2,4,6-三异丙基联苯 以 甲苯 用作溶剂,以83%的收率获得氯(2-二环己基膦基-2',4',6'-三异丙基-1,1'-联苯基)[2-(2'-氨基-1,1'-联苯)]钯(II)
参考文献:A New Palladium Precatalyst Allows For The Fast Suzuki−miyaura Coupling Reactions Of Unstable Polyfluorophenyl And 2-Heteroaryl Boronic Acids
标题:A New Palladium Precatalyst Allows For The Fast Suzuki−miyaura Coupling Reactions Of Unstable Polyfluorophenyl And 2-Heteroaryl Boronic Acids
摘要:Boronic Acids Which Quickly Deboronate Under Basic Conditions,Such As Polyfluorophenylboronic Acid And Five-Membered 2-Heteroaromatic Boronic Acids,Are Especially Challenging Coupling Partners For Suzuki-Miyaura Reactions. Nevertheless,Being Able To Use These Substrates Is Highly Desirable For A Number Of Applications. Having Found That Monodentate Biarylphosphine Ligands Can Promote These Coupling Processes,We Developed A Precatalyst That Forms The Catalytically Active Species Under Conditions Where Boronic Acid Decomposition Is Slow. With This Precatalyst,Suzuki-Miyaura Reactions Of A Wide Range Of (Hetero)Aryl Chlorides,Bromides,And Triflates With Polyfluorophenyl,2-Furan,2-Thiophene,And 2-Pyrroleboronic Acids And Their Analogues Proceed At Room Temperature Or 40 Degrees C In Short Reaction Times To Give The Desired Products In Excellent Yields.
Doi:10.1021/ja1073799