CAS: 153775-33-8; 2,4-Difluoro-5-Nitrobenzoic Acid

相似化合物

67152-20-9 125568-71-0 179011-37-1

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CAS号1583-58-0 2,4-二氟苯甲酸 | CAS号125568-71-0 2,4-二氟-5-硝基苯甲酸甲酯 | CAS号89722-54-3 methyl 4-(benzy... | CAS号639858-45-0 5-氨基-2,4-二氟苯甲酸 | CAS号639858-69-8 5-amino-N-cyclo...

2,4-二氟苯甲酸置于硝酸体系中,用 硫酸 用作溶剂,以61%的收率获得2,4-二氟-5-硝基苯甲酸
参考文献:Antibiotic Compounds
标题:Antibiotic Compounds
摘要:本发明涉及碳青霉烯类药物,并提供了如下式(i)的化合物:##str1##或其药用可接受的盐或体内水解酯,其中:R.Sup.1是1-羟乙基,1-氟乙基或羟甲基;R.Sup.2是氢或c.Sub.1-4烷基;R.Sup.3是氢或c.Sub.1-4烷基;R.Sup.4和r.Sup.5相同或不同,选自氢,卤素,氰基,C.Sub.1-4烷基,硝基,羟基,羧基,C.Sub.1-4烷氧基,C.Sub.1-4烷氧羰基,氨基磺酰基,C.Sub.1-4烷基氨基磺酰基,二c.Sub.1-4烷基氨基磺酰基,氨甲酰基,C.Sub.1-4烷基氨甲酰基,二c.Sub.1-4烷基氨甲酰基,三氟甲基,磺酸,氨基,C.Sub.1-4烷基氨基,二c.Sub.1-4烷基氨基,C.Sub.1-4烷酰胺基,C.Sub.1-4烷酰(N-C.Sub.1-4烷基)氨基,C.Sub.1-4烷磺酰胺基和c.Sub.1-4烷基s(O).Sub.N--其中n为零,一或二:但条件是在--Nr.Sup.2--的邻位没有羟基或羧基取代基.它们的制备方法,制备中间体,作为治疗剂的用途以及含有它们的药物组合物.

专利信息

专利号:US-5994575-A
优先权日:1996-04-16
标 题 :Phenylenediamines and process for preparing the same
发明人：YAZAKI AKIRA; YOSHIDA JIRO; NIINO YOSHIKO
权利人:WAKUNAGA PHARMA CO LTD
摘要:Phenylenediamines represented by general formula (1): ##STR1## wherein R represents an alkyl group or an optionally substituted aralkyl group, X 1 represents a hydrogen atom or a halogen atom, and X 2 represents a halogen atom; salts thereof, and a process for preparing the same. The compounds are useful as intermediates for synthesis of pyridonecarboxylic acid derivatives useful as antibacterial agents.

专利号:US-6136823-A
优先权日:1996-11-28
标题 :Pyridonecarboxylic acid derivatives or salts thereof and drugs containing the same as the active ingredient
发明人：SAKAE NOBUYA; YAZAKI AKIRA; KURAMOTO YASUHIRO; YOSHIDA JIRO; NIINO YOSHIKO; OHSHITA YOSHIHIRO; HIRAO YUZO; HAYASHI NORIHIRO; AMANO HIROTAKA
权利人:WAKUNAGA PHARMA CO LTD
摘要:PCT No. PCT/JP97/04326 Sec. 371 Date May 28, 1999 Sec. 102(e) Date May 28, 1999 PCT Filed Nov. 27, 1997 PCT Pub. No. WO98/23592 PCT Pub. Date Jun. 4, 1998The invention relates to pyridonecarboxylic acid derivatives represented by the general formula (1): wherein R1 is -OH, a carboxy-protecting group or (alkyl)amino group, R2 is H, or -NO2, (protected) amino, (protected) hydroxyl, lower alkyl or lower alkoxyl group, R3 is a halogen atom, H, or -NO2, lower alkyl, lower alkoxyl or amino group, R4 is an azido, (substituted) hydrazino, (substituted) amino, lower alkoxyl or hydroxyl group, R5, R6 and R7 are independently H, -NO2, halogen atom or lower alkyl group, R8 is a -NO2, (substituted) amino, -OH or lower alkoxyl group, A is N or C-R12, in which R12 is H, halogen atom, or (substituted) lower alkyl, lower alkenyl, lower alkynyl, lower alkoxyl, lower alkylthio or nitro group, and B is N or C-R13, in which R13 is H or halogen atom, or salts thereof, and medicine comprising such a compound as an active ingredient. The derivatives or the salts thereof exhibit excellent antibacterial action and peroral absorbability, scarcely cause side effects, and are easy of synthesis.

专利号:RU-2117659-C1
优先权日:1992-02-04
标题:Carbopenem derivatives, their pharmaceutically acceptable salts and hydrolyzed in vivo esters (variants), method of synthesis (variants), pharmaceutical composition showing antibacterial activity, derivatives of pyrrolidine-4-ylthiol and protected derivatives of pyrrolidine-4-ylthiol