CAS: 1632-83-3; 1-Methylbenzimidazole

相似化合物

4981-92-4 7181-87-5 10394-40-8

上下游产品

CAS号51-17-2 苯并咪唑 | CAS号74-88-4 碘甲烷 | CAS号50-00-0 甲醛 | CAS号95-54-5 邻苯二胺(OPD) | CAS号4344-61-0 1-methyl-2-(met... | CAS号612-28-2 N-甲基-2-硝基苯胺 | CAS号122-51-0 原甲酸三乙酯 | CAS号2360-22-7 1-甲基-1H-苯并咪唑-2-硫醇 | CAS号83490-13-5 CHEMBRDG-BB 6423830 | CAS号10504-60-6 四氟硼酸甲基联苯硫酯 | CAS号3878-69-1 1-methyl-2-(1-m... | CAS号85510-65-2 1-methyl-2-(1-m... | CAS号106011-94-3 [1-(1-methylben... | CAS号134-81-6 联苯甲酰 | CAS号13745-35-2 (1-methyl-1H-be... | CAS号4411-80-7 6,6′-二甲基-2,2′-联吡啶 | CAS号143266-97-1 1-methyl-2-(6-m... | CAS号5381-78-2 1-甲基-5-硝基-1H -苯... | CAS号5381-79-3 (9ci)-1-甲基-6-硝基...

N-甲基-2-硝基苯胺置于ammonium Formate,锌体系中,用 乙醇 用作溶剂,化学反应 20.0H,反应生成1-甲基苯并咪唑
参考文献:吲哚rsk抑制剂.第2部分:细胞效能和激酶选择性的优化
标题:吲哚rsk抑制剂.第2部分:细胞效能和激酶选择性的优化
摘要:基于1-Oxo-2,3,4,5-Tetrahydro-1 H-[1,4] Diazepino [1,2-A ] Indole-8的一系列90 Kda核糖体s6激酶(rsk)抑制剂对-羧酰胺支架进行了细胞效力和激酶选择性的优化.这导致了化合物24 Bix 02565的鉴定,Bix 02565是在体外和体内用于探索rsk作为治疗心力衰竭靶标的作用的有吸引力的候选药物.
Doi:10.1016/j.Bmcl.2011.10.029

专利信息

专利号:US-2023287032-A1
优先权日:2020-08-14
标 题:Synthesis of fluorinated nucleotides
发明人：CHUNG CHEOL KEUN; LIU ZHIJIAN; MALIGRES PETER E; MAO EDNA; OBLIGACION JENNIFER V; PHILLIPS ERIC M; PIRNOT MICHAEL; POIRIER MARC; SONG ZHIGUO JAKE; WANG TAO
权利人:CHUNG CHEOL KEUN; LIU ZHIJIAN; MALIGRES PETER E; MAO EDNA; OBLIGACION JENNIFER V; PHILLIPS ERIC M; PIRNOT MICHAEL; POIRIER MARC; SONG ZHIGUO JAKE; WANG TAO; MERCK SHARP & DOHME LLC
摘要:The present invention relates to efficient processes useful in the preparation of fluorinated nucleosides, such as (O—{[(2R,3R,4S,5R)-5-(6-amino-9H-purin-9-yl)-4-fluoro-3-hydroxyoxolan-2-yl]methyl}O,O-dihydrogen phosphorothioate, also known as 2′-(S)-fluoro-thio-adenosine monophosphate or 2′-F-thio-AMP. Such fluorinated nucleosides may be useful as a biologically active compound and or as an intermediate for the synthesis of more complex biologically active compounds. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.

专利号:US-2006058532-A1
优先权日:2004-09-10
标 题:Process for the scalable synthesis of 1,3,4,9-tetrahydropyrano[3,4-b]-indole derivatives
发明人：CHEW WARREN; CHEAL GLORIA K; LUNETTA JACQUELINE F; DEMERSON CHRISTOPHER A
权利人:CHEW WARREN; CHEAL GLORIA K; LUNETTA JACQUELINE F; DEMERSON CHRISTOPHER A
摘要:The invention is directed to a process of synthesizing compounds of formula (VI): n n nwherein R 1- R 9 , R 3′ , R 4′ and Y are as set forth in the specification, and said method is useful for large scale synthesis thereof. The invention is also directed to useful intermediates for synthesizing the compounds of formula (VI) and processes of preparing said intermediates.

专利号:US-2008280855-A1
优先权日:2005-06-22
标 题 :Process For the Production of Intermediates For the Preparation of Tricyclic Benzimidazoles
发明人：CHIESA MARIA VITTORIA; PALMER ANDREAS; BUHR WILM; ZIMMERMANN PETER JAN; BREHM CHRISTOF; SIMON WOLFGANG-ALEXANDER; POSTIUS STEFAN; KROMER WOLFGANG; ZANOTTI-GEROSA ANTONIO
权利人:NYCOMED GMBH
摘要:The invention relates to a process for the synthesis of compounds of the formula 1-a and compounds of the formula 1-b. n n n n n n n n n n The compounds of the formula 1-a and the compounds of the formula 1-b, in which the substituents R1, R2, R3, and Ar have the meanings indicated in the description, are valuable intermediates for the preparation of pharmaceutically active compounds.

专利号:US-2007208164-A1
优先权日:2006-02-27
标题:Methods of synthesizing radiolabeled 3-cyano[14C]quinolines
发明人：OLSZEWSKI JOHN D; MAY MICHAEL K; BERGER DAN M
权利人:WYETH CORP
摘要:The present invention is directed to radiolabeled 3-cyanoquinolines of the formula: n n nand methods of synthesizing the same, wherein G 1 , G 2 R 1 , R 4 , Z, X, and n are as defined herein. n nThe present invention is also directed to a radiolabeled intermediate compounds of formula (VII): n n nwherein PG, G 1 , R 1 , R 4 , R 10 , and R 11 are as defined herein, and synthesis of the same.

专利号:US-10077242-B2
优先权日:2014-12-01
标题 :Convergent approach to the total synthesis of telmisartan via a suzuki cross-coupling reaction
发明人：GUPTON FRANK; MARTIN ALEX; SIAMAKI ALI; BELECKI KATHERINE
权利人:UNIV VIRGINIA COMMONWEALTH
摘要:Methods of synthesizing the angiotensin II receptor antagonist telmisartan in high yield and purity are provided. The methods involve the coupling of two structurally distinct benzimidazole units via a Suzuki cross-coupling reaction. Methods of regioselectively synthesizing one of the benzimidazole units are also provided.

专利号:WO-2007141253-A1
优先权日:2006-06-07
标 题 :Process for the production of intermediates for the preparation of tricyclic imidazopyridines
发明人：PALMER ANDREAS; BUHR WILM; ZIMMERMANN PETER JAN; BREHM CHRISTOF; CHIESA MARIA VITTORIA; ZANOTTI-GEROSA ANTONIO
权利人:NYCOMED GMBH; PALMER ANDREAS; BUHR WILM; ZIMMERMANN PETER JAN; BREHM CHRISTOF; CHIESA MARIA VITTORIA; ZANOTTI-GEROSA ANTONIO
摘要:The invention relates to a process for the synthesis of compounds of the formula (1-a) and compounds of the formula (1-b). The compounds of the formula 1-a and the compounds of the formula 1-b, in which the substituents R1, R2, R3, and Arom have the meanings indicated in the description, are valuable intermediates for the preparation of pharmaceutically active compounds.