CAS: 171557-31-6; 2-(Bis(2-(Tert-Butoxy)-2-Oxoethyl)Amino)Acetic Acid

相似化合物

174267-71-1 85916-13-8 137076-54-1

上下游产品

(Benzyloxycarbonylmethyl-tert-butoxycarbonylmethyl-amino)-acetic acid tert-butyl ester t-butyl iodoacetate tert-butyl esterbromoacetic acid tert-butyl ester

碘乙酸叔丁酯置于palladium On Activated Charcoal Ph 7.0 Phosphate Buffer,氢气体系中,用 甲醇,二甲基亚砜 用作溶剂,化学反应 80.0H,反应生成(双-叔丁氧基羰基甲基-氨基)-乙酸
参考文献:Stereocontrolled Synthesis Of Dtpa Analogs Branched In The Ethylene Unit
标题:Stereocontrolled Synthesis Of Dtpa Analogs Branched In The Ethylene Unit
摘要:Stereochemically Controlled Synthesis Of Diethylenetriaminepentaacetic Acid (Dtpa) Analogues Substituted On The Ethylene Backbones With Methyl Groups,The Chiral Center A To The Terminal Nitrogen Being Derived From (S)-Or (R)-Alanine,Has Been Achieved. The Key Intermediate (S)-Propylenediaminetriacetic Acid Triester Was Synthesized Via Selective Detosylation Of The Alkylation Product Derived From (S)-Alanine And Tert-Butyl Glycinate. Attaching The Remaining Modified Alanine (Or Glycine) Fragment Through Acyl Coupling And Then Selective Reduction Of The Amide Followed By Hydrolysis Of The Esters Afforded The Substituted Dtpa Analogues. Ester Differentiation Has Been Accomplished Through Alkylation Rather Than Acylation Of The (S)-Propylenediaminetriacetic Acid Triester. A Byproduct From This Alkylation Is The Oxazoloisoindole Formed By Internal Alkylation Of The Oxygen Of The Phthaloyl Protecting Group. Phthaloyl Deprotection Followed By Dialkylation Afforded The Ester-Differentiated (S,S)-Dipropylenetriaminepentaacetic Esters. The Enantiomeric Purity Of The Chiral Intermediates (S)-Alaninol And (S)-Propylenediamines Were Determined By HPLC Using Epimeric Standards.
Doi:10.1021/jo00126A059

专利信息

专利号:US-10364262-B2
优先权日:2012-07-17
标 题 :Method for the synthesis of N-phosphonomethyliminodiacetic acid
发明人：DEVAUX ALBERT; BURCK SEBASTIAN; NOTTE PATRICK
权利人:MONSANTO TECHNOLOGY LLC
摘要:A method for synthesis of N-phosphonoalkyliminodiacetic acid or derivatives thereof by forming a reaction mixture having an acid catalyst, a compound of the following general formula R1—CH2—NX—CH2—R2 and a compound having one or more P—O—P anhydride moieties to form a compound having a formula R1—CH2—N(—CH2PO3R32)(—CH2—R2) wherein in R1—CH2—NX—CH2—R2: X is —CH2—OH or —CH2—COOH; R1 and R2 are independently selected from the group consisting of nitrile, C1-C4 alkyl carboxylate, and carboxylic acid for when X is —CH2—OH, or R1 and R2 are both carbonyl groups linked by a hydrogen substituted nitrogen atom or a C1-C4-alkyl substituted nitrogen atom; and R3 is H, an alkyl group, or an aryl group; the anhydride moieties in the P—O—P anhydride compound have one P atom at the oxidation state (+III) and one P atom at the oxidation state (+III) or (+V); and 2) hydrolyzing the mixture to form N-phosphonomethyliminodiacetic acid or one of its derivatives.

专利号:WO-2014012986-A1
优先权日:2012-07-17
标 题:Method for the synthesis of n-phosphonomethyliminodiacetic acid

专利号:US-2015166584-A1
优先权日:2012-07-17
标 题:Method for the synthesis of n-phosphonomethyliminodiacetic acid

专利号:EP-2875038-A1
优先权日:2012-07-17
标 题:Method for the synthesis of n-phosphonomethyliminodiacetic acid