CAS: 2592-18-9; (2S,3R)-2-((Tert-Butoxycarbonyl)Amino)-3-Hydroxybutanoic Acid

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55674-67-4 23082-30-6 85979-33-5

上下游产品

CAS号72-19-5 L-苏氨酸 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号15260-10-3 B°C-O-苄基-L-苏氨酸 | CAS号77313-56-5 B°C-Thr-ONbn | CAS号126587-71-1 B°C-threonine [... | CAS号75844-68-7 TERT-BUTYL 2,3-... | CAS号1070-19-5 Carbonazidic ac... | CAS号104272-92-6 2-t-butoxycarbo... | CAS号104272-95-9 t-butyl S-3,6-d... | CAS号108149-61-7 4-Methyl 3-(2-m... | CAS号48068-25-3 B°C-O-甲基L-苏氨酸 | CAS号95656-86-3 N-(2-羟丙基)氨基甲酸叔丁酯 | CAS号69355-99-3 B°C-O-苄基-D-苏氨酸 | CAS号168034-31-9 B°C-O-苄基-D-苏氨醇 | CAS号119768-44-4 (R)-(2-羟丙基)氨基甲酸叔丁酯 | CAS号174224-64-7 (2S)-2-[[(2S,3R... | CAS号15260-10-3 B°C-O-苄基-L-苏氨酸 | CAS号80082-48-0 TERT-BUTYL ((2S... | CAS号79069-63-9 n-b°C-(2s,3s)-2...

N-Boc-O-苄基-L-苏氨酸置于magnesium,Hydrazinium Monoformate体系中,用 甲醇 用作溶剂,化学反应 1.0H,以90%的收率获得boc-L-苏氨酸
参考文献:镁/肼基甲酸酯:一种新的氢化方法,用于去除肽合成中一些常用的保护基
标题:镁/肼基甲酸酯:一种新的氢化方法,用于去除肽合成中一些常用的保护基
摘要:描述了通过使用一甲酸肼盐和镁的催化转移氢化除去肽合成中一些常用的保护基.在解封肽合成中大多数常用的保护基团方面,该方法与其他方法具有同等竞争力.在这些条件下,叔丁基衍生的和不稳定的碱保护基团是完全稳定的.Mg / Nh 2-Nh 2 .hcooh的使用使它成为钯的快速,低成本替代品,并将后处理减少为简单的萃取操作.
Doi:10.1016/s0040-4039(01)02113-X

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-5783577-A
优先权日:1995-09-15
标题 :Synthesis of quinazolinone libraries and derivatives thereof
发明人：HOUGHTEN RICHARD A; OSTRESH JOHN M
权利人:TREGA BIOSCIENCES INC
摘要:The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.

专利号:US-8138272-B2
优先权日:2006-05-22
标 题:Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds
发明人：KONRADI ANDREI W; SMITH JENIFER L
权利人:KONRADI ANDREI W; SMITH JENIFER L; ELAN PHARM INC
摘要:This invention provides an improved synthesis of polymer conjugates of formula (I), n nof agricultural, therapeutic, and food additive compounds. In particular, a process is described for the preparation of conjugates by treating primary or secondary alcohol substituents of active compounds with polymeric nucleophiles using “Mitsunobuâ€? or related reaction conditions.

专利号:WO-9710221-A1
优先权日:1995-09-15
标 题:Synthesis of quinazolinone libraries
发明人：HOUGHTEN RICHARD A; OSTRESH JOHN M
权利人:TORREY PINES INST
摘要:The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.

专利号:US-6664282-B2
优先权日:1999-09-17
标 题:Synthesis of [3,5,7]-1H-imidazo [1,5-a]imidazol-2 (3H)- one compounds
发明人：ELABDELLAOUI HASSAN M; OSTRESH JOHN M; HOUGHTEN RICHARD A
权利人:TORREY PINES INST
摘要:Individual substituted [3,5,7]-1H-imidazo[1,5-a]imidazol-2(3H)-one compounds and their pharmaceutically-acceptable salts are disclosed, as are libraries of such compounds. Methods of preparing and using the libraries of compounds as well as individual compounds of the libraries are also disclosed.

专利号:US-3842067-A
优先权日:1973-07-27
标 题:Synthesis of(des-asn5)-srif and intermediates
发明人：SARANTAKIS D
权利人:AMERICAN HOME PROD
摘要:AND THE NON-TOXIC ACID ADDITION SALTS THEREOF, SAID AMINO ACID RESIDUES HAVING AN ASYMMETRIC A-CARBON ATOM BEING OF THE L-FORM. H-ALA-GLY-CYS-LYS-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH H-ALA-GLY-CYS-LYS-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH, 1. A COMPOUND SELECTED FROM THOSE OF THE FORMULA: