CAS: 431-67-4; 3,3-Dibromo-1,1,1-Trifluoropropan-2-One

相似化合物

431-35-6 431-91-4 382-12-7

上下游产品

CAS号421-50-1 1,1,1-三氟丙酮(TFK) | CAS号33468-83-6 2-(4-吡啶基)-4-三氟甲基咪唑 | CAS号33469-15-7 2-(4-氯苯基)-4-三氟甲... | CAS号33469-36-2 2-苯基-4-三氟甲基咪唑 | CAS号33468-69-8 4-(三氟甲基)-1H-咪唑 | CAS号69816-38-2 2-氨基-5-三氟甲基吡嗪 | CAS号75-90-1 三氟乙醛 | CAS号33468-71-2 2-naphthalen-2-... | CAS号33468-84-7 3-(4-三氟甲基-1H-咪唑... | CAS号33469-18-0 2-(4-甲基苯基)-4-三氟... | CAS号33469-12-4 2-(4-氟苯基)-5-(三氟...

1,1,1-三氟丙酮置于溴体系中,用46%的收率获得产物1,1-二溴-3,3,3-三氟丙酮
参考文献:2-(三氟甲基)哌嗪:使用NMR和x射线光电子能谱进行合成和表征
标题:2-(三氟甲基)哌嗪:使用NMR和x射线光电子能谱进行合成和表征
摘要:报道了2-(三氟甲基)哌嗪(1)的合成.1 H NMR光谱表明,在椅子型哌嗪环中,Cf 3基团位于赤道位置.固体1的x射线光电子能谱表明,Cf 3基团在其最邻近的碳原子的c 1 S核心结合能上引起1.5 Ev的二次(β)化学位移.半经验的pm3和ham / 3计算支持了该结果.
DOI:10.1002/recl.19951140305

专利信息

专利号:US-10226449-B2
优先权日:2013-12-20
标 题:Heterocyclic modulators of lipid synthesis and combinations thereof
发明人：HEUER TIMOTHY SEAN; OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; DUKE GREGORY; OHOL-GUPTA YAMINI; O'FARRELL MARIE
权利人:3 V BIOSCIENCES INC
摘要:Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by dysregulation of a fatty acid synthase pathway by the administration of such compounds and combinations of such compounds and other therapeutic agents.

专利号:US-9428502-B2
优先权日:2012-07-03
标题:Heterocyclic modulators of lipid synthesis
发明人：OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; WAGMAN ALLAN S
权利人:3-V BIOSCIENCES INC
摘要:Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by disregulation of a fatty acid synthase pathway by the administration of such compounds.

专利号:US-11999741-B2
优先权日:2017-05-26
标 题:Process for the synthesis of 6-((3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl)-3-(tetrahydropyran-4-yl-7H-imidazo[1,5-a]pyrazin-8-one
发明人：SVENSTRUP NIELS; ZHANG JUN; SUN JIKUI; CHEN YUYIN; KONG JIANSHE; MA RUJIAN; ZHANG JUNHUA; QIN LIANG; XIAO HUANMING; SUN JINXU; MENG XIAO; SUN FENGLAI; ZHU JINGYANG
权利人:CARDURION PHARMACEUTICALS INC
摘要:The present disclosure relates to processes for preparing 64(3s,4s)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl)-3-(tetrahydropyran-4-yl-7h-imidazo[1,5-a]pyrazin-8-one.

专利号:US-2025019381-A1
优先权日:2017-05-26
标题 :PROCESS FOR THE SYNTHESIS OF 6-((3S,4S)-4-METHYL-1-(PYRIMIDIN-2-YLMETHYL)PYRROLIDIN-3-YL)-3-(TETRAHYDROPYRAN-4-YL-7H-IMIDAZO[1,5-a]PYRAZIN-8-ONE

专利号:US-11370795-B2
优先权日:2017-05-26
标 题 :Process for the synthesis of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-3-tetrahydropyran-4-yl-7H-imidazo[1,5-a]pyrazin-8-one

专利号:US-2018222892-A1
优先权日:2012-07-03
标 题 :Heterocyclic modulators of lipid synthesis