CAS: 446-08-2; 2-Amino-5-Fluorobenzoic Acid

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CAS号320-98-9 2-硝基-5-氟苯甲酸 | CAS号399-52-0 5-氟吲哚 | CAS号394-28-5 2-溴-5-氟苯甲酸 | CAS号446-33-3 5-氟-2-硝基甲苯 | CAS号443-69-6 5-氟靛红 | CAS号351-09-7 对氟异亚硝基乙酰苯胺 | CAS号49579-56-8 2-乙酰氨基-5-氟苯甲酸 | CAS号326-65-8 2-乙酰氨基-5-氟甲苯 | CAS号321-69-7 5-氟靛红酸酐 | CAS号319-24-4 2-氨基-5-氟苯甲酸甲酯 | CAS号394-28-5 2-溴-5-氟苯甲酸 | CAS号49579-56-8 2-乙酰氨基-5-氟苯甲酸 | CAS号2343-25-1 2-氨基-5-氟苯乙酮 | CAS号78755-80-3 7-氟-3.4-二氢-4-甲基... | CAS号88145-90-8 6-氟喹唑啉-2,4-二醇 | CAS号877264-44-3 5-氟-2-碘苯甲醛 | CAS号877264-43-2 (5-氟-2-碘苯基)甲醇

5-氟靛红置于双氧水,Sodium Hydroxide体系中,用 水 作为反应溶剂,化学反应生成 2-氨基-5-氟苯甲酸
参考文献:合成新的1,2,3-三唑并[1,5-A]喹唑啉酮
标题:合成新的1,2,3-三唑并[1,5-A]喹唑啉酮
摘要:通过适当的取代的2-叠氮基苯甲酸酯的阴离子杂多米诺反应,合成高产率的新型3-取代的1,2,3,3-三唑并[1,5-A]喹唑啉酮,所述取代基由由1,3-活化的靛红和乙腈制备的2-叠氮基苯甲酸酯噻唑,1,3-苯并噻唑,1,3,4-恶二唑和1,2,4-恶二唑环.已表明乙腈显示出高反应性并且是用于此类反应的方便的亚甲基化合物,提供了快速的结构变化.j.杂环化学.(2010).
DOI:10.1002/jhet.321

专利信息

专利号:US-7230101-B1
优先权日:2002-08-28
标 题:Synthesis of methotrexate-containing heterodimeric molecules
发明人：MURTHI KRISHNA K; SMITH CHASE C
权利人:GPC BIOTECH INC
摘要:The present invention relates to novel compositions of methotrexate-containing heterodimeric probe molecules, also known as chemical inducers of dimerization (CID), useful in three-hybrid assays. The invention further relates to synthesis of said compositions and their intermediates. Another aspect of the invention is a method for using the heterodimeric probe molecules described herein in drug screens to identify potential protein targets to a given ligand, optimize protein-ligand interactions, or identify potential ligands for a given protein target. In certain embodiments, the invention contemplates the synthesis of the following methotrexate-containing heterodimeric probe:

专利号:US-5783577-A
优先权日:1995-09-15
标题 :Synthesis of quinazolinone libraries and derivatives thereof
发明人：HOUGHTEN RICHARD A; OSTRESH JOHN M
权利人:TREGA BIOSCIENCES INC
摘要:The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.

专利号:US-9453037-B2
优先权日:2011-07-28
标 题 :Methylphenidate-prodrugs, processes of making and using the same
发明人：GUENTHER SVEN; CHI GUOCHEN; BERA BINDU; MICKLE TRAVIS; BERA SANJIB
权利人:KEMPHARM INC; KEMPHARM INC
摘要:The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof.

专利号:US-12416015-B2
优先权日:2017-09-15
标题:Multiplex production and barcoding of genetically engineered cells
发明人：ROY KEVIN; SMITH JUSTIN D; ST ONGE ROBERT P; STEINMETZ LARS M; HABER JAMES E
权利人:UNIV LELAND STANFORD JUNIOR; UNIV BRANDEIS
摘要:The present disclosure relates to multiplex production and phenotyping of genetically engineered cells using RNA-guided nucleases and genomic barcoding. In particular, high-throughput multiplex genome editing is achieved utilizing a system that facilitates precise genome editing at desired target chromosomal loci by homology directed repair. Integration of guide RNA and donor DNA sequences as a genomic barcode at a separate chromosomal locus allows identification, isolation, and massively-parallel validation of individual variants from a pool of transformants. Strains can be arrayed according to their precise genetic modifications, as specified by donor DNA incorporation in heterologous or native genes. The present disclosure further relates to a method of editing codons outside of canonical guide RNA recognition regions, which enables complete saturation mutagenesis of protein-coding genes, a marker-based internal cloning method, which removes background due to oligonucleotide synthesis errors and incomplete vector backbone cleavage, and a method of enhancing homology directed repair by active donor recruitment.

专利号:WO-9811438-A1
优先权日:1996-09-13
标题 :Synthesis of quinazolinone libraries and derivatives thereof

专利号:US-5925647-A
优先权日:1995-06-07
标 题 :Methods for use of cryptolepine analogs with hypoglycemic activity
发明人：BIERER DONALD E
权利人:SHAMAN PHARMACEUTICALS INC
摘要:Novel cryptolepine analogs useful as hypoglycemic agents and methods for their use as hypoglycemic agents, for example, in the treatment of diabetes, and a method for their synthesis are described. As hypoglycemic agents, the novel cryptolepine analogs are useful for the treatment of insulin-dependent diabetes mellitus (IDDM or Type I) and non-insulin dependent diabetes mellitus (NIDDM or Type II).