Z-Gly-Asp(Obu)-Oh置于palladium On Activated Charcoal 氢气,对甲苯磺酸体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 48.0H,反应生成 甘氨酰-L-天冬氨酸 参考文献:Synthesis And Antiviral Activity Of Vp1 Fragments Of The Aphthous Fever Virus 标题:Synthesis And Antiviral Activity Of Vp1 Fragments Of The Aphthous Fever Virus 摘要: DOI:10.1007/bf02464250
专利号:EP-2588602-A1 优先权日:2010-07-01 标题:Variants of glucoamylase 发明人:DEGN PETER EDVARD; BOTT RICHARD R; VROEMEN CASPER WILLEM; SCHEFFERS MARTIJN SILVAN; AEHLE WOLFGANG; PETERSEN ELIN 权利人:DUPONT NUTRITION BIOSCI APS; DANISCO US INC 摘要:The present invention relates to combinatorial variants of a parent glucoamylase that have altered properties for reducing the synthesis of condensation products during hydrolysis of starch. Accordingly the variants of a parent glucoamylase are suitable such as for use within brewing and glucose syrup production. Also disclosed are DMA constructs encoding the variants and methods of producing the glucoamylase variants in host cells.
专利号:US-2009069239-A1 优先权日:2007-09-06 标题 :Use of Iridoptin to Induce Toxicity in Insects 发明人:BILIMORIA SHAN L 权利人:UNIV TEXAS TECH 摘要:Improved methods and compounds to control insects, involving a biological control method to induce toxicity in targeted insects using iridoptin. The present invention induces high levels of apoptosis and inhibition of host protein synthesis in insect cells. It is the first viral toxin against non-lepidopteran insects and is distinct from existing bacterial toxins, such as Bacillus thuringiensis toxins, which are not effective against most beetles, including the boll weevil, and the Baculoviridae, which is the main group of viruses currently used as biological control agents. Iridoptin will have use in the control of agricultural pests. It will increase productivity and reduce disease transfer by vectors and household pests. By extension it has application in cancer therapy and other medical treatments where apoptosis is critical to removal of certain cells.
专利号:US-6087332-A 优先权日:1997-12-23 标 题 :Streptokinase derivatives with high affinity for activated platelets and methods of their production and use in thrombolytic therapy 发明人:GALLER LAWRENCE ISAAC 摘要:Streptokinase derivatives having platelet glycoprotein binding domains adjacent to the termini of the streptokinase sequence. These derivatives produce higher local concentrations of plasmin in vivo as compared to unmodified streptokinase. Certain of the derivatives have high affinity for the GPIIB/IIIA receptor and low affinity for the fibronectin and vitronectin receptors. Others have substantially equivalent affinity for all three receptors. The derivatives are useful in treating thromboembolic disorders. The streptokinase derivatives can be made by recombinant techniques or by chemical synthesis or conjugation.
专利号:CN-115073587-A 优先权日:2022-07-08 标 题 :A kind of synthetic process of semi-continuous liquid phase synthesis of bivalirudin
专利号:US-9751911-B2 优先权日:2012-11-27 标 题:Solomonamide analogue compounds, pharmaceuticals containing solomonamide analogue compounds, and processes for the preparation thereof 发明人:REDDY DUMBALA SRINIVASA; KOMIRISHETTY KASHINATH; NATARAJAN VASUDEVAN 权利人:COUNCIL SCIENT IND RES 摘要:Solomanamide analogs of Formula-I having anti-inflammatory activity, and viable synthetic routes for the preparation of such analogs, including the synthesis of macrocyclic core of Salomanamide analogs. The Solomanamide analogs of Formula-I or their pharmaceutical salt may be provided in a pharmaceutical composition and administered in an effective amount for the treatment of inflammation and/or pain.
专利号:CA-2394414-A1 优先权日:1999-12-16 标 题 :Moss genes from physcomitrella patens encoding proteins involved in the synthesis of tocopherols carotenoids