CAS: 938-97-6; 2-Amino-2-(4-Hydroxyphenyl)Acetic Acid

• 英文名称2-Amino-2-(4-Hydroxyphenyl)Acetic Acid
• 中文名称DL-对羟基苯甘氨酸
• IUPAC名称2-amino-2-(4-hydroxyphenyl)acetic acid
• 其它别名2-Amino-2-(4-Hydroxyphenyl)Acetic Acid; 4-Hydroxyphenylglycine; Dl-4-Hydroxyphenylglycine; Dl-P-Hydroxyphenylglycine; Amino(4-Hydroxyphenyl)Acetic Acid; (Rs)-2-(4-Hydroxyphenyl)Glycine; Alpha-Amino-4-Hydroxybenzeneacetic Acid; 7Uyg7X0F53; Chebi
• CAS编号938-97-6
• MFCD编号:MFCD00065931
• EINECS号:213-353-2
• 分子式:C8H9NO3
• 分子量:167.16
• 产品CID: 1982054
• 产品分类有机原料→生命科学→氨基酸及其衍生物→甘氨酸及其衍生物

• 相似结构搜索
• 产品信息参考;
• InChIKey: LJCWONGJFPCTTL-UHFFFAOYNA-N
• InChI=1S/C8H9NO3/c9-7(8(11)12)5-1-3-6(10)4-2-5/h1-4,7,10H,9H2,(H,11,12)…
• 计算化学: 氢键受体数3.0氢键供体数3.0可旋转键数2.0

相似化合物

物理性质

• 熔点240°C
• 沸点446.3°C at 760 mmHg
• 闪点223.7 °C
• 密度1.411g/cm3
• pKa:2.15±0.10(预测)
• PSA:83.55
• LogP:0.4766
• 折射率1.547
• 蒸汽压1.7E-06 mmHg at 25 °C
• 溶解性DMSO (Very Slightly, Heated), Water (Slightly, Heated, Sonicated)
• 外观形态白色至淡黄色固体
• 储存条件请置于阴暗处, 惰性气氛中,室温
• 产品应用羟氨苄青霉素;头孢哌酮等β-内酰胺类抗生素的中间体(用D型).
• 性质描述R型(即D型):结晶,熔点240°C(分解),[α]-158.4°(C=1,1mol/LHCl).(+,-)型:片状结晶(水),难溶于水,乙醚中不溶,200°C不熔分解.

MSDS等安全信息

• GHS符号GHS07
• 警示词Warning
• 危险描述H302-H315-H319-H335
• 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
• 危险等级IRRITANT
• 危险品标志Xi

上下游产品

合成工艺路线路线简述

• 936565-30-9 + 22818-40-2 = 938-97-6
  反应条件:1.1 Reagents: Sodium Carbonate Solvents: Methanol; Rt -> 60 °C; 2 H,60 °C
  标题:Asymmetric Resolution Of D-P-Hydroxyphenylglycine
  作者:Yang,Fan; Zhang,Zhenglin; Zou,Jianzhong
  参考文献:Zhongguo Yiyao Gongye Zazhi 日期:2005 卷标:36(4) 页码:199-200]
  
  123-08-0 = 938-97-6
  反应条件:1.1 Solvents: Methanol,Water; 10 Min,Rt1.2 Reagents: Trisodium Citrate Solvents: Water; 25 °C; 30 °C1.3 Reagents: Sulfuric Acid; Ph 31.4 Reagents: Carbon Dioxide,Ammonia Solvents: Water; 30 °C -> 80 °C; 80 °C -> 120 °C; 0.8 - 1 Mpa,120 °C -> 140 °C; 0.5 Mpa,101 °C1.5 Reagents: Sodium Hydroxide Solvents: Water; 0.8 - 1 Mpa,178 °C; 0.5 Mpa,101 °C1.6 Reagents: Sulfuric Acid Solvents: Water; Ph 5 - 5.5,< 100 °C; 100 °C -> 35 °C
  标题:Process For Preparation Of D,L-Phenylglycine Derivatives
  参考文献:China]
  
  86788-93-4 = 938-97-6
  反应条件:1.1 Reagents: P-Toluenesulfonic Acid Solvents: Acetonitrile
  标题:Deprotection Of 4-Methoxybenzyloxycarbonyl Group With P-Toluenesulfonic Acid In Acetonitrile. Application To A Large-Scale Preparation Of 7-[d-2-Amino-2-(4-Hydroxyphenyl)Acetamido]Cephalosporanic Acid
  作者:Yamada,Hirotada; Tobiki,Hisao; Tanno,Norihiko; Suzuki,Hiroyuki; Jimpo,Kiyokazu; Et Al
  参考文献:Bulletin Of The Chemical Society Of Japan 日期:1984 卷标:57(11) 页码:3333-4]
  
  1198-84-1 = 938-97-6 [标题:Reaction Conditions
  标题:Synthesis Of Dl-2-(P-Hydroxyphenyl)Glycine By The Ammonolysis Of P-Hydroxymandelic Acid Obtained By The Condensation Of Phenol With Glyoxylic Acid
  作者:Powar,Netaji P.; Chandalia,Sampatraj B.
  参考文献:Journal Of Chemical Technology And Biotechnology 日期:1989 卷标:46(3) 页码:219-32]
  
  298-12-4 = 938-97-6
  反应条件:1.1 Reagents: Sulfamic Acid Catalysts: Benzyltriethylammonium Chloride; Rt -> 70 °C; 8 H,70 °C1.2 Reagents: Ammonium Hydroxide Solvents: Water; Ph 7; Cooled
  标题:Study On Synthesis Of Dl-P-Hydroxyphenylglycine
  作者:Pei,Lei; Liu,Fusheng; Yu,Shitao
  参考文献:Jingxi Shiyou Huagong Jinzhan 日期:2007 卷标:8(11) 页码:20-23]
  
  123-08-0 + 7677-24-9 = 938-97-6
  反应条件:1.1 Reagents: Benzylamine Solvents: Ethanol1.2 Solvents: Tetrahydrofuran1.3 Reagents: Ammonium Chloride Solvents: Tetrahydrofuran,Water1.4 Reagents: Hydrochloric Acid Solvents: Water1.5 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol
  标题:Novel Method Of Preparing Hydroxyarylglycines,Alkoxyarylglycines And The Glycinates Thereof,From Aromatic Aldehydes And Benzylamine
  参考文献:World Intellectual Property Organization]
  
  298-12-4 = 938-97-6
  反应条件:1.1 Reagents: Stearyldimethylbenzylammonium Chloride Solvents: Water; Rt -> 60 °C; 15 Min,60 °C1.2 Reagents: Benzoic Acid; 8 H,60 °C; 60 °C -> Rt1.3 Reagents: Potassium Carbonate Solvents: Water; Ph 6,Rt
  标题:The Preparation Of D-4-Hydroxyphenylglycine
  作者:Zhang,Da-Shuai; Mu,Shuai; Niu,Duan; Liu,Ying; Wang,Ping-Bao; Et Al
  参考文献:Jingxi Huagong Zhongjianti 日期:2013 卷标:43(2) 页码:33-36]
  
  69322-01-6 = 938-97-6
  反应条件:1.1 Solvents: Water
  标题:Process For Preparing An Alpha-Amino Acid,The Corresponding Ester And Amide
  参考文献:European Patent Organization]
  
  123-08-0 = 938-97-6
  反应条件:1.1 Reagents: Potassium Hydroxide,β-Cyclodextrin,Ammonia Catalysts: Hexadecyltrimethylammonium Bromide Solvents: Dichloromethane,Water
  标题:Synthesis Of P-Hydroxyphenylglycine
  作者:Liu,Changchun
  参考文献:Huagong Shikan 日期:2001 卷标:15(9) 页码:25-27]
  
  69322-01-6 = 938-97-6
  反应条件:1.1 Reagents: Ammonium Hydroxide,Ammonium Chloride
  标题:P-Hydroxyphenylglycine Or An N-Alkyl Or An N,N-Dialkyl Derivative
  参考文献:Netherlands]
  
  298-12-4 = 938-97-6
  反应条件:1.1 Reagents: Sulfamic Acid Solvents: Water; 45 Min,120 °C
  标题:Preparation Of Dl-4-Hydroxyphenylglycine In Pulse Tube Reactor
  参考文献:China]
  
  298-12-4 = 938-97-6
  反应条件:1.1 Catalysts: P-Toluenesulfonic Acid; 20 H,35 °C1.2 Reagents: Sodium Hydroxide,Sodium Bisulfite Solvents: Water; Ph 3,25 °C
  标题:Method For Synthesizing P-Hydroxyphenylglycine
  参考文献:China]
  
  4746-62-7 = 938-97-6
  反应条件:1.1 Reagents: Phosphoric Acid; Rt -> 65 °C; 7 H,60 - 65 °C1.2 Reagents: Sodium Bicarbonate Solvents: Water; Ph 4.8
  标题:Process For Preparation Of 4-Hydroxyphenylglycine
  参考文献:China]
  
  298-12-4 = 938-97-6
  反应条件:1.1 Reagents: Sulfamic Acid Catalysts: Sulfuric Acid Solvents: Water; 5 - 6 H,70 °C1.2 Reagents: Ammonia Solvents: Water; 24 H,Ph 7
  标题:Study On Synthesis Of Dl-P-Hydroxyphenylglycine
  作者:Zhang,Jing; Tu,Wei-Ping
  参考文献:Yingyong Huagong 日期:2003 卷标:32(5) 页码:46-48]
  
  298-12-4 = 938-97-6
  反应条件:1.1 Reagents: Sulfamic Acid Catalysts: Phosphoric Acid Solvents: Hexane,Water; 70 - 75 °C; 2 H; 4 H1.2 Solvents: Water; 65 - 70 °C1.3 Reagents: Ammonia Solvents: Water; Ph 3 - 5
  标题:Method For Preparation Of P-Hydroxyphenylglycine
  参考文献:China]
  
  298-12-4 = 938-97-6
  反应条件:1.1 Reagents: Sulfamic Acid Catalysts: Sodium Hydroxide,Ammonium Nitrate,Aluminum Hydroxide Solvents: Water; Rt -> 60 °C; 7 H,60 °C; 60 °C -> Rt1.2 Reagents: Ammonium Hydroxide; Ph 6,Rt; 1 H,Rt
  标题:Solid Acid Catalyst And Preparation Method Thereof And Preparation Method Of Para-Hydroxyphenylglycine
  参考文献:China]
  
  298-12-4 = 938-97-6
  反应条件:1.1 Reagents: Sulfamic Acid; 28 °C1.2 76 °C
  标题:An In-Depth Mechanistic Study Of The P-Hydroxyphenylglycine Synthetic Process Using In Situ Atr-Ir Spectroscopy
  作者:Mao,Hai-Fang; Xing,Hui-Min; Jin,Miao-Miao; Liu,Ji-Bo; Yao,Yue-Liang; Et Al
  参考文献:Analytical Methods 日期:2022 卷标:14(29) 页码:2833-2840]
  
  298-12-4 = 938-97-6
  反应条件:1.1 Reagents: 4-Nitrophthalimide; 10 H,65 °C; 65 °C -> 25 °C
  标题:Process For Preparation Of Dl-P-Hydroxyphenylglycine
  参考文献:China]
  
  298-12-4 = 938-97-6
  反应条件:1.1 Catalysts: P-Toluenesulfonamide,Ethylene Glycol; 30 °C; 20 °C; 35 °C; 65 °C1.2 Ph 4 - 51.3 Reagents: Ammonia Solvents: Water; Ph 7,35 - 45 °C
  标题:Production Method And Device Of D,L-P-Hydroxyphenylglycine By Adopting Staged Temperature Control Of Multi-Stage Tubular Reactor,Continuous Neutralization And Kettle-Type Reactor
  参考文献:China]
  
  298-12-4 = 938-97-6
  反应条件:1.1 Reagents: Urea,Potassium Chlorate Solvents: Water1.2 Reagents: Sulfamic Acid; 2 H,20 °C
  标题:Process For Preparation Of Dl-4-Hydroxyphenylglycine
  参考文献:China

海关参考信息

• 2902600000-乙苯
  2912110000-甲醛
  2912120000-乙醛
  2915110000-甲酸
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• ➥ 象形图和危险代码
• ➥ 防范代码详解
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