CAS: 104121-92-8; (1R,2R,3R,Z)-5-(2-((1R,3As,7Ar,E)-1-((R)-6-Hydroxy-6-Methylheptan-2-yl)-7A-Methyloctahydro-4H-Inden-4-Ylidene)Ethylidene)-2-(3-Hydroxypropoxy)-4-Methylenecyclohexane-1,3-Diol

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CAS号342645-84-5 (1β,2α,3α,5Z,7E... | CAS号342644-91-1 [3R-(1Z,3β,4α,5... | CAS号342645-07-2 (1α,2β,3β,5Z,7E... | CAS号66774-80-9 Inhoffen Lythgo... | CAS号200636-54-0 [3R-(1Z,3β,4α,5... | CAS号244278-87-3 [3R-(1Z,3β,4α,5... | CAS号377091-68-4 [3R-(1Z,3β,4α,5... | CAS号342644-83-1 [3R-(1Z,3β,4α,5...

维生素 D3置于正丁基锂,Oxone,1,1,1-三氟丙酮,碳酸氢钠,对甲苯磺酸,臭氧体系中,用 四氢呋喃,甲醇,正己烷,二氯甲烷,水,乙腈 用作溶剂,化学反应 37.5H,反应生成艾地骨化醇
参考文献:二十烷醇的大规模合成
标题:二十烷醇的大规模合成
摘要:描述了工业规模的去骨钙糖醇的合成.在室温下,Aa对苯甲氧基苄基(pmb)保护的二烯醇的高度非对映选择性环氧化提供了带有仲羟基的关键环氧化物中间体,该中间体被三氟甲磺酸烷基化以在c-1,C-2处建立所有亚基,A环片段的c-3位置.选择性的保护基操作,然后进行钯催化的环化,即可提供a环合成子.C / D环片段是通过(1)使用原位制备的三氟丙酮二环氧乙烷直接将grundman'S酮的ch直接羟基化和(2)保护获得的.最后,A环与c / D环片段的偶联,整体脱保护和重结晶提供了高度结晶的去骨钙糖醇.
Doi:10.1021/acs.Oprd.0C00436

专利信息

专利号:US-2022267266-A1
优先权日:2019-07-09
标 题 :Improved, cost effective process for synthesis of vitamin d3 and its analogue calcifediol from ergosterol
发明人：DATLA ANUPAMA; NAGRE PRASHANT; TAMORE JAGDISH; PRABHU MANOJKUMAR SADANAND; KADAM SACHIN VASANT
权利人:FERMENTA BIOTECH LTD
摘要:Disclosed herein is an improved and efficient process for synthesis of vitamin D3 and its analogue Calcifediol from Ergosterol. Particularly, the present invention discloses the synthesis of key intermediate 3β-tert-Butyldimethylsilyloxy-22-hydroxy-23,24-bisnorchola-5,7-diene (5), and novel intermediate β-tert-Butyldimethylsilyloxy-22-iodo-23,24-bisnorchola-5,7-diene (9) by a simple and cost effective process. The industrially viable processes for preparation of said intermediate(s) results in providing provitamins with various side chains and the desired products in high yield.

专利号:WO-2025108575-A1
优先权日:2023-11-21
标 题:Methods of selective deprotection and synthesis of transhydrindane- skeleton-based compounds
发明人：HUBER FLORIAN MAURITIUS ERASMUS
权利人:ROCHE DIAGNOSTICS GMBH
摘要:The present invention relates to methods of selectively deprotecting a transhydrindane-skeleton-based compound comprising at least two different silyl ether groups. The present invention further relates to methods of synthesizing a Vitamin D molecule and to Vitamin D molecules obtainable by such processes. Furthermore, the present invention relates to a compound according to formula (I) comprising two different silyl ether groups, its use in the synthesis of Vitamin D molecules and to methods of producing such a compound.

专利号:US-11591280-B2
优先权日:2019-05-13
标题:Process and intermediates for the preparation of eldecalcitol
发明人：HERNÃ?NDEZ HERRERO GONZALO; GARCÃ?A DOMÃ?NGUEZ NEFTALÃ?; SUÃ?REZ CORTÉS TATIANA MARÃ?A; GONZÃ?LEZ GARCÃ?A TANIA; GÓMEZ PÃ?CIOS GENEROSA; FALL DIOP YAGAMARE; SANTALLA GARCÃ?A HUGO; GARRIDO FERNÃ?NDEZ FÃ?TIMA
权利人:FAES FARMA SA
摘要:The invention relates to new intermediates in the synthesis of Eldecalcitol and to processes for the preparation of said intermediates and of Eldecalcitol.