CAS: 17193-39-4; (S)-Methyl 2-Amino-3-Cyclohexylpropanoate Hydrochloride

相似化合物

144644-00-8 98105-41-0 40056-18-6

上下游产品

CAS号7524-50-7 L-苯丙氨酸甲酯盐酸盐 | CAS号67-56-1 甲醇 | CAS号25528-71-6 β环己基丙氨酸盐酸盐 | CAS号98105-41-0 (S)-2-((叔丁氧基羰基)... | CAS号27527-05-5 (S)-2-氨基-3-环己基羧酸 | CAS号63-91-2 L-苯丙氨酸 | CAS号51987-73-6 N-B°C-L-苯丙氨酸甲酯 | CAS号25341-42-8 Cbz-L-环己基丙氨酸 | CAS号105192-90-3 achpa | CAS号25528-71-6 β环己基丙氨酸盐酸盐 | CAS号40056-18-6 (S)-METHYL 2-AM...

L-苯丙氨酸甲酯盐酸盐置于rh/al2O3 氢气体系中,用 甲醇 用作溶剂,以95%的收率获得l-环己基丙氨酸甲酯盐酸盐
参考文献:苯并恶唑胺和苯并噻唑胺:白三烯生物合成的有效,对映选择性抑制剂,具有新颖的作用机理.
标题:苯并恶唑胺和苯并噻唑胺:白三烯生物合成的有效,对映选择性抑制剂,具有新颖的作用机理.
摘要:描述了一系列抑制白三烯(lt)生物合成的苯并恶唑胺和苯并噻唑胺类似物.最初的铅(S)-N-(苯并噻唑-2-基)苯丙氨酸乙酯(5A)在筛选程序中被发现,该程序可抑制ca-离子载体-A23187诱导的人多形核白细胞释放ltb4(ic50 0.23 Microm ).通过结构修饰,确定了5-位上的疏水取代基以及苯丙氨酸的苯环被环己基取代极大地增强了效能.描述了几种保留效力和对映异构体选择性的酯类生物甾体.铅优化最终达到(S)-N-[2-环己基-1-(2-吡啶基)乙基]-5-甲基-2-苯并恶唑胺+ ++(43B),Ic50 0.001 Microm.所述化合物不是5-脂氧合酶的抑制剂,而是
Doi:10.1021/jm00033A008

专利信息

专利号:US-2005032187-A1
优先权日:2003-08-01
标题:Novel peptide-forming enzyme, microbe producing the enzyme and method for producing peptide using them
发明人：YOKOZEKI KENZO; SUZUKI SONOKO; HARA SEIICHI; KATAYAMA SATOSHI
权利人:AJINOMOTO KK
摘要:The present invention relates to a novel enzyme that allows peptide to be produced easily, inexpensively and at high yield without going through a complex synthesis method. More particularly, the present invention provides a novel enzyme that catalyzes a peptide-producing reaction from a carboxy component and an amine component, a microbe that produces the enzyme, and a method for inexpensive production of peptides using this enzyme or microbe. The novel enzyme that efficiently produces peptide was discovered from a newly discovered microbe belonging to the genus Empedobacter , and a method was found that allows peptides to be produced inexpensively and easily.

专利号:US-2005032154-A1
优先权日:2002-07-26
标题 :Method for producing tripeptides and/or peptides longer than tripeptides
发明人：YOKOZEKI KENZO; SUZUKI SONOKO; HARA SEIICHI; ABE ISAO
权利人:AJINOMOTO KK
摘要:It is an object of the present invention to provide a method that allows the production of peptides that are equal to or longer than tripeptides easily, inexpensively and at high yield without going through a complex synthesis method. The inventors of the present invention have found a novel enzyme that efficiently produces a peptide from bacteria belonging to the genus Empedobacter or the genus Sphingobacterium . In the present invention, this enzyme is allowed to act on a carboxy component and an amine component to produce peptides that are equal to or longer than tripeptides.

专利号:US-5523410-A
优先权日:1992-07-02
标 题 :Intermediate for synthesis and production of amino acid derivative
发明人：KAGARA KOOJI; KAWAI NOBUTAKA; MACHIYA KOJI; FURUTERA TETSUO; NAKAMURA TAKASHI; OMORI HIROKI
权利人:FUJISAWA PHARMACEUTICAL CO
摘要:The present invention relates to synthetic intermediates useful for preparing amino acid derivatives possessing renin-inhibitory activity, and to processes for preparing the amino acid derivatives using the synthetic intermediates.

专利号:US-7749742-B2
优先权日:2002-07-26
标 题:Method for producing tripeptides and/or peptides longer than tripeptides
发明人：YOKOZEKI KENZO; SUZUKI SONOKO; HARA SEIICHI; ABE ISAO
权利人:AJINOMOTO KK
摘要:A method is disclosed that allows the production of peptides having three or more amino acid residues easily, inexpensively and at high yield without going through a complex synthesis method. A novel enzyme that efficiently produces a peptide from bacteria belonging to the genus Empedobacter or the genus Sphingobacterium is provided. The enzyme acts on a carboxy component and an amine component to form peptides having three or more amino acid residues by acting on a carboxy component and an amine component.

专利号:EP-0648747-A1
优先权日:1992-07-02
标题:Novel intermediate for synthesis and production of amino acid derivative