CAS: 200124-22-7; (S)-2-((Tert-Butoxycarbonyl)Amino)-5-(3-((2,2,4,6,7-Pentamethyl-2,3-Dihydrobenzofuran-5-yl)Sulfonyl)Guanidino)Pentanoic Acid

相似化合物

186698-61-3 154445-77-9 187618-60-6

上下游产品

CAS号24424-99-5 二碳酸二叔丁酯 | CAS号200115-86-2 N5-[[[(2,3-二氢-2...

Boc-Arg(Pbf)-Oh置于水,Lithium Hydroxide体系中,用 四氢呋喃 用作溶剂,化学反应 3.0H,反应生成N-叔丁氧羰基-N'-(2,2,4,6,7-五甲基二氢苯并呋喃-5-磺酰基)-L-精氨酸
参考文献:Triazole Groups As Biomimetic Amide Groups In Peptides Can Trigger Racemization
标题:Triazole Groups As Biomimetic Amide Groups In Peptides Can Trigger Racemization
摘要:
Doi:10.24820/ark.5550190.P011.484

专利信息

专利号:WO-2023030277-A1
优先权日:2021-08-30
标 题:Method for fully liquid-phase synthesis of grnh nonapeptide amide analog
发明人：SUN PENGCHENG; PAN JING; WU JUNYONG; TANG YONGBO; Du Yixiong; GUO LIN
权利人:HUNAN MICRO PEPTIDE BIOMEDICAL CO LTD
摘要:Provided is a method for fully liquid-phase synthesis of a GRnH nonapeptide amide analog, which belongs to the technical field of medicine synthesis. The method comprises respectively synthesizing a 'Trp-Ser-Tyr' fragment, an 'R-Leu' fragment, a 'Pyr-His' fragment and 'Arg-Pro-Hunan T', wherein, R = D-Ala (alarelin), D-Leu (leuprorelin), D-Trp (deslorelin) and D-His (histrelin), and obtaining the GRnH nonapeptide amide analog with high yield and high purity by means of a '3 +2 +2 +2' fragment condensation method. The synthesis method is environmentally friendly, mild, and free of any highly toxic and poisonable reagents. The cost is greatly reduced and the synthesis method is very suitable for large-scale production.

专利号:US-2018265547-A1
优先权日:2014-07-18
标 题 :Z-selective olefin metathesis of peptides
发明人：MANGOLD SHANE L; GRUBBS ROBERT H
权利人:CALIFORNIA INST OF TECHN
摘要:The invention relates generally to the synthesis of modified amino acids and modified peptides in the presence of cyclometalated catalysts. The invention has utility in the fields of catalysis, organic synthesis, polymer chemistry, and industrial and fine chemicals chemistry.

专利号:WO-2013057186-A1
优先权日:2011-10-19
标题 :Photolabile linker for the synthesis of hydroxamic acids
发明人：NIELSEN THOMAS E; QVORTRUP KATRINE
权利人:UNIV DANMARKS TEKNISKE
摘要:The present invention relates to a photolabile hydroxamate linker based on the o - nitroveratryl group and its application for multistep solid-phase synthesis and controlled photolytic release of hydroxamic acids. The invention provides a method for producing a solid support comprising a hydroxylamine - functionalized photolabile linker, and the so produced hydroxylamine - functionalized photolabile solid support. The invention further provides a method for synthesizing a one-bead-one compound library of hydroxamic acid derivatives on a photolabile linker, as well as a method for screening a library of hydroxamic acid derivatives.

专利号:CN-103159819-A
优先权日:2013-03-29
标题 :Synthesis of a Cholesterol Derivative and Its Application in Gene Transfection

专利号:ES-2616871-T3
优先权日:2009-06-01
标 题 :Synthesis of relaxin peptide

专利号:US-12172946-B2
优先权日:2019-01-07
标题:Compound containing diphenylmethane structure and use thereof
发明人：LIANG WEIZHOU; ZHENG QINGQUAN; TANG QI
权利人:GUANGZHOU TROJAN PHARMATEC LTD
摘要:A structure of the compound containing a diphenylmethane structure of the present invention is represented by General Formula (1). The compound containing a diphenylmethane structure of the present invention contains a hydroxyl group, an amino group, a substituted amino group, and an active group, and can be used as an amino acid or peptide C-terminal protection reagent. A peptide synthesis reaction using this protection carrier has a fast reaction speed and a high reagent utilization rate in a suitable solvent system; post-treatment is carried out by means of simple liquid-liquid extraction separation, i.e. effective purification can be carried out, and finally, a product with a high purity can be obtained; and during a synthesis process, the change in solubility is small and an operation process has a strong universality, and therefore, the present method can be developed into a universal production method.