CAS: 61764-71-4; Methyl Prop-2-Yn-1-Yl Carbonate

相似化合物

623-53-0 35466-83-2 56525-42-9

2-丙炔-1-醇,氯甲酸甲酯 以 吡啶,乙醚 作为反应溶剂,化学反应 3.0H,以82%的收率获得产物甲基羧酸-2-丙炔基酯
参考文献:Synthesis Of Phenylthiomethyl Substitution Furans By Lewis Acid Catalysed Substitution
标题:Synthesis Of Phenylthiomethyl Substitution Furans By Lewis Acid Catalysed Substitution
摘要:介绍了两条合成不同功能化三取代呋喃甲基4-甲基-2-[(苯硫基)甲基]-3-呋喃酸酯的路线.一条是直接的钯催化环化反应,能在硫醚的存在下顺利进行;另一条依赖于苯硫基三甲基硅烷对甲氧基的高度化学选择性取代.对后者转化的范围和机制进行了简单模型体系的研究.
DOI:10.1055/s-1993-26011

专利信息

专利号:US-8431693-B2
优先权日:2004-04-05
标题:Process for desilylation of oligonucleotides
发明人：MANOHARAN MUTHIAH; JUNG MICHAEL F; RAJEEV KALLANTHOTTATHIL G; PANDEY RAJENDRA K; WANG GANG
权利人:MANOHARAN MUTHIAH; JUNG MICHAEL F; RAJEEV KALLANTHOTTATHIL G; PANDEY RAJENDRA K; WANG GANG; ALNYLAM PHARMACEUTICALS INC
摘要:The present invention relates to processes and reagents for oligonucleotide synthesis and purification. One aspect of the present invention relates to compounds useful for activating phosphoramidites in oligonucleotide synthesis. Another aspect of the present invention relates to a method of preparing oligonucleotides via the phosphoramidite method using an activator of the invention. Another aspect of the present invention relates to sulfur-transfer agents. In a preferred embodiment, the sulfur-transfer agent is a 3-amino-1,2,4-dithiazolidine-5-one. Another aspect of the present invention relates to a method of preparing a phosphorothioate by treating a phosphite with a sulfur-transfer reagent of the invention. In a preferred embodiment, the sulfur-transfer agent is a 3-amino-1,2,4-dithiazolidine-5-one. Another aspect of the present invention relates to compounds that scavenge acrylonitrile produced during the deprotection of phosphate groups bearing ethylnitrile protecting groups. In a preferred embodiment, the acrylonitrile scavenger is a polymer-bound thiol. Another aspect of the present invention relates to agents used to oxidize a phosphite to a phosphate. In a preferred embodiment, the oxidizing agent is sodium chlorite, chloroamine, or pyridine-N-oxide. Another aspect of the present invention relates to methods of purifying an oligonucleotide by annealing a first single-stranded oligonucleotide and second single-stranded oligonucleotide to form a double-stranded oligonucleotide; and subjecting the double-stranded oligonucleotide to chromatographic purification. In a preferred embodiment, the chromatographic purification is high-performance liquid chromatography.

专利号:US-8221719-B2
优先权日:2007-09-05
标 题:Luminescent lanthanide (III) chelates, chelating agents and conjugates derived thereof
发明人：PEURALAHTI JARI; HOVINEN JARI; KETOLA JANNE; JAAKKOLA LASSI; MUKKALA VELI-MATTI; LIITTI PAEIVI
权利人:PEURALAHTI JARI; HOVINEN JARI; KETOLA JANNE; JAAKKOLA LASSI; MUKKALA VELI-MATTI; LIITTI PAEIVI; WALLAC OY
摘要:This invention relates to a group of novel chelating agents, novel chelates, biomolecules labeled with said chelates or chelating agents as well as solid supports conjugated with said chelates, chelating agents or labeled biomolecules. Especially the invention relates to novel chelating agents useful in solid phase synthesis of oligonucleotides or oligopeptides and the oligonucleotides and oligopeptides so obtained.