CAS: 622-47-9; 2-(P-Tolyl)Acetic Acid

上下游产品

(4-methylphenyl)acetonitrile °Ctane para-xylene n-pentylsodium (E,E)-1-(4-methylphenyl)-4-phenylbuta-1,3-diene 3-(4-methylbenzyliden)-3H-isobenzofuran-1-one trans-stilben-4-yl)-2-p-tolyl-acrylic acid3ξ-(trans-stilben-4-yl)-2-p-tolyl-acrylic acid 4-Methylphenethyl alcohol

[sbph3(O2Cch2(C6H4Ch3))2]置于谷胱甘肽体系中,用 乙醇,水 作为反应溶剂,化学反应 24.0H,反应生成 对甲基苯乙酸
参考文献:Bi(V) 和 Sb(V) 抗利什曼配合物的硫醇还原
标题:Bi(V) 和 Sb(V) 抗利什曼配合物的硫醇还原
摘要:包括锥虫硫酮和谷胱甘肽在内的低分子量硫醇在利什曼原虫物种的细胞生长,维持和减少氧化应激中发挥重要作用.特别是,寄生虫特异性锥虫硫酮已被确定为新的抗利什曼原虫药物的主要目标.先前对基于 Sb(V) 的一线抗利什曼病药物葡甲胺锑酸盐与谷胱甘肽相互作用的研究表明,还原途径可能是其有效和选择性的原因.一组新的有机金属配合物,通式为 [mar 3 (O 2 Cr) 2](m = Sb 或 Bi)已被证明具有作为新的选择性候选药物的潜力.然而,它们对关键硫醇谷胱甘肽和锥虫硫酮的行为仍然很大程度上未知.使用 NMR 光谱和质谱,我们检测了类似的 Sb(V) 和 Bi(V) 有机金属配合物 [sbph 3 (O 2 Cch 2 (C 6 H 4 Ch 3)) 2] S1和 [biph 3 (O 2 Cch 2 (C 6 H 4 Ch 3)) 2] B1,与锥虫硫酮和 L-谷胱甘肽的三氟乙酸 (Tfa)
DOI:10.1016/j.Jinorgbio.2021.111470

专利信息

专利号:US-4045452-A
优先权日:1974-03-13
标题 :Steroid total synthesis process utilizing a cyanoalkyl A-ring precursor
发明人：COHEN NOAL; ROSENBERGER MICHAEL; SAUCY GABRIEL
权利人:HOFFMANN LA ROCHE
摘要:A multi-step, stereospecific total synthesis of steroids utilizing intermediates having a cyanoalkyl A-ring precursor is disclosed. The initial starting materials for this process are the relatively inexpensive and commercially available reagents γ-butyrolactone and sodium cyanide. The process is suitable for the preparation of racemic or optically active, medicinally valuable steroids, particularly 19-norsteroids. It is a feature of this process that conditions employed during the multiple step synthesis are selected so as to retain the normally labile nitrile group even during hydrogenation and hydrolysis steps. In this manner, it is possible to employ the nitrile group as an A-ring precursor without resorting to protective groups as wasl heretofore found necessary in previous steroid total synthesis processes.

专利号:US-4105676-A
优先权日:1975-12-22
标题 :Steroid total synthesis process utilizing a cyanoalkyl a-ring precursor
发明人：COHEN NOAL; ROSENBERGER MICHAEL; SAUCY GABRIEL
权利人:HOFFMANN LA ROCHE
摘要:A multi-step, stereospecific total synthesis of steroids utilizing intermediates having a cyanoalkyl A-ring precursor is disclosed. The initial starting materials for this process are the relatively inexpensive and commercially available reagents γ-butyrolactone and sodium cyanide. The process is suitable for the preparation of racemic or optically active, medicinally valuable steroids, particularly 19-norsteroids. It is a feature of this process that conditions employed during the multiple step synthesis are selected so as to retain the normally labile nitrile group even during hydrogenation and hydrolysis steps. In this manner, it is possible to employ the nitrile group as an A-ring precursor without resorting to protective groups as was heretofore found necessary in previous steroid total synthesis processes.

专利号:US-3965138-A
优先权日:1974-03-13
标 题:Steroid total synthesis process utilizing a cyanoalkyl A-ring precursor
发明人：COHEN NOAL; ROSENBERGER MICHAEL; SAUCY GABRIEL
权利人:HOFFMANN LA ROCHE
摘要:A multi-step, stereospecific total synthesis of steroids utilizing intermediates having a cyanoalkyl A-ring precursor is disclosed. The initial starting materials for this process are the relatively inexpensive and commercially available reagents γ-butyrolactone and sodium cyanide. The process is suitable for the preparation of racemic or optically active, medicinally valuable steroids, particularly 19-norsteroids. It is a feature of this process that conditions employed during the multiple step synthesis are selected so as to retain the normally labile nitrile group even during hydrogenation and hydrolysis steps. In this manner, it is possible to employ the nitrile group as an A-ring precursor without resorting to protective groups as was heretofore found necessary in previous steroid total synthesis processes.

专利号:US-3991084-A
优先权日:1970-08-26
标题 :Steroid total synthesis process utilizing a cyanoalkyl A-ring precursor
发明人：COHEN NOAL; ROSENBERGER MICHAEL; SAUCY GABRIEL
权利人:HOFFMANN LA ROCHE
摘要:A multi-step, stereospecific total synthesis of steroids utilizing intermediates having a cyanoalkyl A-ring precursor is disclosed. The initial starting materials for this process are the relatively inexpensive and commercially available reagents γ-butyrolactone and sodium cyanide. The process is suitable for the preparation of racemic or optically active, medicinally valuable steroids, particularly 19-norsteroids. It is a feature of this process that conditions employed during the multiple step synthesis are selected so as to retain the normally labile nitrile group even during hydrogenation and hydrolysis steps. In this manner, it is possible to employ the nitrile group as an A-ring precursor without resorting to protective groups as was heretofore found necessary in previous steroid total synthesis processes.

专利号:US-2004014168-A1
优先权日:1998-06-11
标题:Reagents and methods for library synthesis and screening
发明人：SCHREIBER STUART L; BLACKWELL HELEN E; PEREZ FERNANDEZ LUCY; TALLARICO JOHN A
权利人:HUGHES HOWARD MED INST
摘要:The invention provides novel solid supports for the synthesis of compound libraries. The solid supports have the physical capacity to deliver at least 50 nmol of compound and are functionalized with a silicon-containing linker. In one embodiment of the invention the solid support comprises a bead having a diameter of between approximately 400 and 600 μm functionalized with a silicon-containing linker. According to certain embodiments of the invention the bead is a polystyrene bead. According to certain embodiments of the invention the linker is a diisopropylalkyl-substituted silyl ether. The invention further provides grafted polymeric supports such as lanterns functionalized with a silicon-containing linker. n The invention provides methods for screening in which compounds are synthesized on solid supports in a quantity so that a single solid support such as a bead provides a stock solution sufficient to perform hundreds or thousands of biological or chemical assays. The methods include decoding the sequence of chemical reactions used to synthesize the compound by identifying tags incorporated into the compound during synthesis.

专利号:US-9181292-B2
优先权日:2011-01-05
标题 :Methods for preparation of glycosphingolipids and uses thereof
发明人：LIANG PI-HUI
权利人:LIANG PI-HUI
摘要:Methods for synthesis and preparation of alpha-glycosphingolipids are provided. Methods for synthesis of α-galactosyl ceramide, and pharmaceutically active analogs and variants thereof are provided. Novel alpha-glycosphingolipids are provided, wherein the compounds are immunogenic compounds which serve as ligands for NKT (natural killer T) cells.