CAS: 716-61-0; (1R,2R)-2-Amino-1-(4-Nitrophenyl)Propane-1,3-Diol

上下游产品

(+/-)-threo-1-(4-nitro-phenyl)-2-amino-1,3-propanediol S,3S)-2-amino-3-methoxy-3-(4-nitro-phenyl)-propan-1-ol(2S,3S)-2-amino-3-methoxy-3-(4-nitro-phenyl)-propan-1-ol R,2S)-2-acetylamino-1-(4-nitro-phenyl)-propane-1,3-diol(1R,2S)-2-acetylamino-1-(4-nitro-phenyl)-propane-1,3-diol (1S,2S)-2-acetamido-1-phenylpropane-1,3-diyl diacetateS,2S)-1-(4-nitro-phenyl)-2-[2]pyridylmethylenamino-propane-1,3-diol(1S,2S)-1-(4-nitro-phenyl)-2-[2]pyridylmethylenamino-propane-1,3-diol S,2S)-2-benzoylamino-1-(4-nitro-phenyl)-propane-1,3-diol(1S,2S)-2-benzoylamino-1-(4-nitro-phenyl)-propane-1,3-diol S,2S)-2-(furan-2-carbonylamino)-1-(4-nitro-phenyl)-propane-1,3-diol(1S,2S)-2-(furan-2-carbonylamino)-1-(4-nitro-phenyl)-propane-1,3-diol N-[(1S,2S)-2-hydroxy-1-hydroxymethyl-2-(4-nitro-phenyl)-ethyl]-phthalamic acidN-[(1S,2S)-2-hydroxy-1-hydroxymethyl-2-(4-nitro-phenyl)-ethyl]-phthalamic acid

氯霉素置于盐酸体系中,用 水 作为反应溶剂,化学反应 2.0H,反应生成 (1R,2R)-2-氨基-1-(4-硝基苯基)丙烷-1,3-二醇
参考文献:氯霉素的triphenilphosphonium类似物作为双重作用的抗菌剂和抗增殖剂
标题:氯霉素的triphenilphosphonium类似物作为双重作用的抗菌剂和抗增殖剂
摘要:在当前的工作中,我们在继续我们的最新研究的基础上,合成并研究了新的嵌合化合物,包括靶向核糖体的抗生素氯霉素(chl)和膜穿透性阳离子三苯基phosph(tpp),它们通过不同长度的烷基连接.使用各种生化分析,我们表明这些cam-Cn-Tpp化合物与细菌核糖体结合,以与母体chl类似的方式在体内和体外抑制蛋白质合成,并显着降低膜电位.与cam-C4-Tpp相似,细菌核糖体中cam-C10-Tpp和cam-C14-Tpp的作用方式与chl不同.通过模拟细菌核糖体的cam-Cn-Tpp复合物的动力学,我们提出了这些类似物在翻译过程中作用的特异性的可能解释.与chl相比,Cam-C10-Tpp和cam-C14-Tpp更强烈地抑制革兰氏阳性细菌的生长,并抑制一些对chl耐药的菌株.因此,我们已经表明chl的tpp衍生物是针对细菌的核糖体和细胞膜的双重作用化合物.cam-Cn-Tpp化合物的tpp片段
DOI:10.3390/antibiotics10050489

专利信息

专利号:US-11512303-B2
优先权日:2017-05-27
标 题 :Engineered polypeptides and their applications in the synthesis of beta-hydroxy-alpha-amino acids
发明人：CHEN HAIBIN; BONG YONG KOY; XU QING; ZHOU AMENG; SHEN TIANRAN; YANG JIADONG; YANG ZHUHONG
权利人:ENZYMASTER NINGBO BIO ENG CO LTD
摘要:The present invention provides engineered polypeptides that are useful for the asymmetric synthesis of β-hydroxy-α-amino acids under industrial-relevant conditions. The engineered polypeptides disclosed in this invention were developed through directed evolution based on the ability of catalytic synthesis of (2S, 3R)-2-amino-3-hydroxy-3-(4-nitrophenyl) propanoic acid. The present disclosure also provides polynucleotides encoding engineered polypeptides, host cells capable of expressing engineered polypeptides, and methods of producing β-hydroxy-α-amino acids using engineered polypeptides. Compared to other processes of preparation, the use of the engineered polypeptides of the present invention for the preparation of β-hydroxy-α-amino acids results in high purity of the desired stereoisomers, mild reaction conditions, low pollution and low energy consumption. So, it has good industrial application prospects.

专利号:US-2021284987-A1
优先权日:2017-05-27
标 题:Engineered polypeptides and their applications in the synthesis of beta-hydroxy-alpha-amino acids

专利号:EP-3630798-B1
优先权日:2017-05-27
标 题:Engineered aldolase polypeptides and their applications in synthesis of beta-hydroxy-alpha-amino acids

专利号:US-11286270-B2
优先权日:2017-10-11
标 题:Boronic acid derivatives and synthesis thereof
发明人：HECKER SCOTT J; BOYER SERGE HENRI; DIELEMANS HUBERTUS J A; GONZALEZ DE CASTRO ANGELA; DE VRIES ANDREAS H M; LEFORT LAURENT
权利人:QPEX BIOPHARMA INC
摘要:Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the method of use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents, for example, β-lactamase inhibitors (BLIs).

专利号:EP-1644384-B1
优先权日:2002-12-11
标 题:Process and intermediates for the synthesis of entecavir

专利号:CN-108323173-A
优先权日:2018-01-22
标 题:A kind of method of enzymatic synthesis chloramphenicol intermediate