CAS: 932-96-7; 4-Chloro-N-Methylaniline

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CAS号106-47-8 对氯苯胺 | CAS号74-88-4 碘甲烷 | CAS号698-69-1 4-氯-N,N-二甲基苯胺 | CAS号106-39-8 对氯溴苯 | CAS号74-89-5 氨基甲烷 | CAS号2617-79-0 N-(4-氯苯)甲酰胺 | CAS号128965-91-3 α-(4-chloro-phe... | CAS号27032-10-6 p-Chlorobenzyl ... | CAS号100-61-8 N-甲基苯胺 | CAS号26772-93-0 4'-氯-N-甲基甲酰苯胺 | CAS号35113-88-3 2,4-二氯-N-甲基苯胺 | CAS号845870-55-5 4-(N-甲基氨基)苯基硼酸,频哪醇酯 | CAS号100-61-8 N-甲基苯胺 | CAS号698-69-1 4-氯-N,N-二甲基苯胺 | CAS号1007-19-8 N-(4-chlorophen... | CAS号10218-95-8 N-(4-氯苯基)-n-甲基硫... | CAS号3365-81-9 N-甲基-[1,1-联苯]-4-胺 | CAS号623-09-6 N-甲基对苯二胺 | CAS号1197300-24-5 3-(2-氯苯基)-n-(4-... | CAS号14529-12-5 N-甲基-5-氯靛红酸酐

4-氯-N,N-二甲基苯胺置于三乙胺体系中,用 乙腈 作为反应溶剂,以70 %的收率获得产物4-氯-N-甲基苯胺
参考文献:碱驱动的光诱导芳基叔胺和酰胺的 N-脱烷基化
标题:碱驱动的光诱导芳基叔胺和酰胺的 N-脱烷基化
摘要:基于量子力学计算的预测和细致实验的验证,我们将先前提出的芳基叔胺的光致氧化机理扩展到碱性环境,发现了芳基叔胺和酰胺的光致氧化n-脱烷基化方法.脱烷基化是在碱性环境和温和条件下实现的,并且具有优异的官能团耐受性.
DOI:10.1021/acs.Orglett.3C03519

专利信息

专利号:US-11325912-B2
优先权日:2019-05-09
标题 :Regio-selective synthesis of imidazo[1,2-a]pyrimidines
发明人：CLAGG KYLE BRADLEY PASCUAL; WHITE NICHOLAS ANDREW; ZHANG HAIMING; GOSSELIN FRANCIS; NACK WILLIAM; O'SHEA PAUL D
权利人:GENENTECH INC
摘要:A method of regio-selectively synthesizing an imidazo-pyrimidine compound of formulae (XXa) or (XXb)comprising a step of coupling a first compound of formula XX-P1a or XX-P1b with a second compound of formula XX-P2This annulation reaction between β-ethoxy acrylamides and phosphorylated aminoimidazoles to furnish imidazo[1,2-a]pyrimidin-amines relies on steering effects from endocyclic and exocyclic phosphorylated aminoimidazoles. The reaction furnishes either 2-amino or 4-amino constitutional isomers of imidazo[1,2-a]pyrimidines with good yields and ranges of 90:10-99:1 regio-selectivity. The reaction is useful in the synthesis of various tracer molecules used in the study of neurological conditions such as where R3 and R4 together with the imidazole ring atoms to which they are bonded form a phenyl ring and the products are substituted benzimidazopyrimidines. The reaction can be generalized to form imidazo[1,2-a]pyrimidines substituted at either of their 2- and 4-positions by alkoxy or thioalkyl groups.

专利号:US-6348616-B1
优先权日:1996-07-26
标题 :Practical synthesis of benzoxazinones useful as HIV reverse transcriptase inhibitors
发明人：PIERCE MICHAEL ERNEST; RADESCA LILIAN ALICIA
摘要:The present invention describes novel methods for the synthesis of benzoxazinone compounds which are useful as human immunodeficiency virus (HIV) reverse transcriptase inhibitors. The benzoxazinone of the formula:is particularly effective in the treatment of HIV.

专利号:WO-2015058868-A1
优先权日:2013-10-25
标题 :Compositions and methods for the treatment of cancer
发明人：JIMENO DOÑAQUE JOSÉ Mª
权利人:PANGAEA BIOTECH S L
摘要:The invention relates to anti-tumor compounds which have been designed to functionally disrupt the cross-talk between AEG-1 and the p65 subunit of NF-κB. Therefore, the invention relates to methods and compositions for the treatment of cancer using the compounds identified in the present invention, as well as compositions adequate for sustained release of the compounds of the invention to be administered to the surgical site after resection of the tumor. The invention also provides methods for the synthesis of the compounds of the invention.

专利号:US-9676783-B2
优先权日:2008-10-22
标 题:Method of treatment using substituted pyrazolo[1,5-A] pyrimidine compounds
发明人：HAAS JULIA; ANDREWS STEVEN W; JIANG YUTONG; ZHANG GAN
权利人:ARRAY BIOPHARMA INC
摘要:Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.

专利号:US-8846898-B2
优先权日:2000-10-17
标题:Phosphinoamidite carboxylates and analogs thereof in the synthesis of oligonucleotide having reduced internucleotide charge
发明人：DELLINGER DOUGLAS J
权利人:DELLINGER DOUGLAS J; Lieure Cornu LLC
摘要:Nucleoside phosphinoamidite carboxylates and analogs are provided that have the structure of formula (III) n nwherein A is hydrogen, hydroxyl, lower alkoxy, lower alkoxy-substituted lower alkoxy, halogen, SH, NH 2 , azide or DL wherein D is O, S or NH and L is a heteroatom-protecting group, unsubstituted hydrocarbyl, substituted hydrocarbyl, heteroatom-containing hydrocarbyl, or substituted heteroatom-containing hydrocarbyl; B is a nucleobase; and one of R 11 and R 12 is a blocking group and the other is (IV) or (VI)n n nin which W, X, Y, Z, R 1 and n are as defined herein.

专利号:WO-2024163852-A1
优先权日:2023-02-03
标题:Histidine kinase inhibitors as antibacterial agents
发明人：CARLSON ERIN ELIZABETH; GOSWAMI MANIBARSHA; ESPINASSE ADELINE; JI YINDUO
权利人:UNIV MINNESOTA
摘要:The invention provides maleimide derivative compounds of Formula I, as histidine kinase inhibitors, useful for inhibiting bacterial histidine kinases, such as HK853 and AirS, for treating S. aureus bacterial infections, in particular methicillin-resistant S. aureus (MRSA). The invention further provides methods of treating bacterial infection with the. compounds of Formula I, either used alone or in combination with other agents in a therapeutic regimen. Further disclosed is the synthesis of the compounds of Formula I.