6-己内酯-2-酮置于氢溴酸体系中,化学反应生成6-溴-2-己酮 参考文献:Lipp,Justus Liebigs Annalen Der Chemie,1896,Vol. 289,P. 229 标题:Lipp,Justus Liebigs Annalen Der Chemie,1896,Vol. 289,P. 229
专利信息
专利号:US-9751851-B2 优先权日:2013-09-20 标 题:Molecules and compositions that inhibit gram negative bacteria and their uses 发明人:BASSLER BONNIE L; SEMMELHACK MARTIN F; DRESCHER KNUT; SIRYAPORN ALBERT; CONRAD-MILLER LAURA C; O'LOUGHLIN COLLEEN T 权利人:UNIV PRINCETON; BASSLER BONNIE L; SEMMELHACK MARTIN F; DRESCHER KNUT; SIRYAPORN ALBERT; MILLER LAURA C; O'LOUGHLIN COLLEEN T 摘要:Antivirulence strategies to combat Pseudomonas aeruginosa , are described. One strategy encompasses synthesis of a series of compounds that inhibit the production of pyocyanin, a redox-active virulence factor produced by this pathogen. A related strategy encompasses synthesis of compounds that inhibit the two P. aeruginosa quorum-sensing receptors, LasR and RhlR, inhibit production of pyocyanin, and inhibit biofilm formation.