CAS: 1075198-30-9; 4-(6-Cyano-2-Methyl-7-Oxo-4,8-Dioxa-2,5-Diazadec-5-En-3-Ylidene)Morpholin-4-Ium Hexafluorophosphate(V)

相似化合物

136849-72-4 790600-30-5 198011-60-8

专利信息

专利号:WO-2024261319-A1
优先权日:2023-06-23
标题 :Methods of chemical synthesis of peptides
发明人：AL MUSAIMI OTHMAN; WILLIAMS DARYL ROBERT
权利人:IMPERIAL COLLEGE INNOVATIONS LTD
摘要:The present invention relates to methods for the synthesis of peptides and related compounds supported on a solid polymeric resin. The inventive method provides synthetic schemes that permit the coupling of two or more peptide fragments attached to the same polymeric support, in a fashion that allows access to previously unobtainable structures, and provides a more convenient and higher-yielding approach to known peptides, including those of commercial significance.

专利号:WO-2024163644-A1
优先权日:2023-02-01
标题:Belt reactor manufacturing process for oligomer synthesis
发明人：KELLER KARSTEN; HILLEBRAND ROMAN
权利人:ARROWHEAD PHARMACEUTICALS INC
摘要:A method and apparatus for synthesis of oligomers such as oligonucleotides and peptides are disclosed. The method employs a device including at least one deprotection station to carry out a step of deprotection, at least one coupling station to carry out a step of coupling, optionally, one or more oxidation and/or thiolation stations to carry out a step of oxidation or thiolation, optionally, one or more capping stations to carry out a step of capping, and, optionally, one or more washing stations to carry out a step of washing. A plurality of solid phase material for oligomer synthesis is moved to the stations via a conveyor device, wherein a fluid delivery device acts upon said solid phase material to produce an oligomer.

专利号:US-2023391818-A1
优先权日:2020-11-05
标 题:Peptide synthesis method for suppressing defect caused by diketopiperazine formation
发明人：NOMURA KENICHI; KAGE MIRAI; TAMIYA MINORU; KANAZAWA JUNICHIRO
权利人:CHUGAI PHARMACEUTICAL CO LTD
摘要:Solid-phase synthesis of a peptide has a problem that a desired elongation reaction is prevented from proceeding by diketopiperazine and a 6-membered diamine skeleton compound formed when a protective group at the N-terminal is removed. The present inventors have found that when in production of a peptide by a solid-phase method, a peptide in which an amino group at the N-terminal is protected with a protective group having an Fmoc skeleton is treated in a specific solvent with a base having a pKa of 23 or more in acetonitrile as a conjugate acid, and a peptide chain is then elongated, it is possible to solve the problem described above.

专利号:US-10822371-B2
优先权日:2017-12-06
标题 :Solid phase synthesis of NIR fluorescent probe
发明人：CAMPANELLA RAPHAEL; CLOUET ANTHONY; LATTUADA LUCIANO
权利人:BRACCO IMAGING SPA
摘要:The present invention discloses a solid-phase process for the preparation of a Near Infra-Red (NIR) fluorescent probe characterized by an aza-bicycloalkane based cyclic peptide labelled with a Cy5.5 dye moiety and used in the guided surgery of tumors and pathologic regions.

专利号:WO-2024103123-A1
优先权日:2022-11-17
标题 :The synthesis of omapatrilat
发明人：VITALE ROMINA; MARTIN VINCENT ALEXANDRE; FABER WIJNAND; SOMMER ROMAN
权利人:ENDOTHELIUM SCANNING NANOTECHNOLOGY LTD
摘要:Described herein are improved methods of making Compound 1 (4S,7S,10aS)-4-((S)-2- mercapto-3-phenylpropanamido)-5-oxooctahydro-7H-pyrido[2,1-b][1,3]thiazepine-7-carboxylic acid, or Omapatrilat, and purified Omapatrilat obtained from the improved methods.

专利号:US-10544186-B2
优先权日:2016-11-09
标题:Process for the synthesis of amide bonds with the aid of novel catalysts
发明人：IGNATYEV NIKOLAI MYKOLA; FRANK WALTER; BARTHEN PETER; VYSOTSKY MYROSLAV
权利人:MERCK PATENT GMBH
摘要:The invention relates to a process for the production of amide bonds, in particular peptide bonds, with the aid of novel amide linking reagents containing an anion of the formula (I), to the novel reagents, and to the preparation thereof.