专利号:US-5981240-A 优先权日:1996-11-27 标题:Enzyme-catalyzed synthesis of macromolecules in organic solvents 发明人:AKKARA JOSEPH A; BRUNO FERDINANDO F 权利人:US ARMY 摘要:A method is described for a simple, fast and efficient synthesis of homopolymers and copolymers by the enzymatic ring opening polymerization of lactones and lactides. The enzyme used is an ion paired protease. The advantage of this enzymatic system is in using small amount of enzyme per monomer and lower reaction time. Homopolymers and copolymers are synthesized with molecular weights between 1000 and 4600 daltons, and dispersity as low as 1.1. The monomer conversion after 4 days, for reactions catalyzed by protease S, has reached 100%. Different initiators are used to control the rate and degree of polymerization. Synthesis of block copolymers with defined block size and crystallinity are described in this invention. These biodegradable and bioerodable polyesters and copolyesters with controlled molecular weight, dispersity and crystallinity have applications in medical, drug, cosmetic and food industries.
专利号:US-10793495-B2 优先权日:2015-08-14 标 题:Synthesis of polyaryl substituted aryl compounds 发明人:BOULOS RAMIZ; FEUTRILL JOHN 权利人:BOULOS & COOPER PHARMACEUTICALS PTY LTD 摘要:A method for the synthesis of a aryl compound of Formula (1).n nU T-W—R 1 ) n    (1)
专利号:US-2023323449-A1 优先权日:2021-12-17 标 题:Compositions and methods for detection of variants 发明人:GANTT RICHARD; ARNESON ADRIANA 权利人:TWIST BIOSCIENCE CORP 摘要:Testing the many hypotheses from genomics and systems biology experiments demands accurate and cost-effective gene and genome synthesis. Here we describe a microchip-based technology for multiplex gene synthesis. Pools of thousands of ‘construction’ oligonucleotides and tagged complementary ‘selection’ oligonucleotides are synthesized on photo-programmable microfluidic chips, released, amplified and selected by hybridization to reduce synthesis errors ninefold. A one-step polymerase assembly multiplexing reaction assembles these into multiple genes. This technology enabled us to synthesize all 21 genes that encode the proteins of the Escherichia coli 30S ribosomal subunit, and to optimize their translation efficiency in vitro through alteration of codon bias. This is a significant step towards the synthesis of ribosomes in vitro and should have utility for synthetic biology in general.
专利号:US-2024082118-A1 优先权日:2021-05-19 标 题:Topical compositions and methods of preparing the same 发明人:ABRAMOVICH SAGI; AVIDOR GAL; LANDA BENZION 权利人:LANDA LABS 2012 LTD 摘要:There is disclosed a composition comprising a water-insoluble thermoplastic compound capable of stimulating collagen synthesis (CSSC), the CSSC having a molecular weight of more than 0.6 kDa and being dispersed in a polar carrier as nano-elements having an average diameter of 200 nm or less and a viscosity of 107 mPa·s or less. The nano-elements of CSSC can be capable of stimulating the synthesis of skin proteins and/or enabling the delivery of active agents upon their application to a surface to be treated therewith. Methods for preparing the compositions and uses thereof are also provided.
专利号:US-9068192-B2 优先权日:2009-01-28 标 题:Compositions and methods for conversion of aldehydes to alkanes 发明人:ZENG WEIQING; HE SHENG YANG 权利人:ZENG WEIQING; HE SHENG YANG; UNIV MICHIGAN STATE 摘要:The invention provides the discovery that SCD2 (Susceptible to Coronatine-Deficient Pst DC3118-2) protein converts aldehydes to alkanes, thereby changing the composition and/or amount of synthesized waxes. The invention additionally provides homologs, orthologs and paralogs of SCD2 protein, and nucleotide sequences encoding these proteins. Also provided are expression vectors, transgenic cells, transgenic plants, transgenic seeds, methods for altering alkane production in cells, methods for identifying the function of a nucleotide sequence in the synthesis of plant surface wax, and methods for identifying plant tissue that has an altered surface wax composition. The invention's compositions and methods are useful for altering the amount and/or composition of wax produced by cells, including plants and seeds, that have been transformed with the invention's sequences.