CAS: 1888-89-7; 1,5-Hexadiene Diepoxide

相似化合物

2426-07-5 2855-19-8 2984-50-1

上下游产品

Perbenzoic acid 1,5-Hexadien 1,6-diiodo-hexane-2,5-diol epichlorohydrin hexane-2,5-diol cyclohex-2-ene-1,4-diol

1,5-已二烯置于间氯过氧苯甲酸体系中,用 二氯甲烷 用作溶剂,以87%的收率获得1,5-己二烯二环氧化物
参考文献:7-N,7'-N'-(1″,2″-Dithianyl-3″,6″-Dimethylenyl)Bismitomycin C: Synthesis And Nucleophilic Activation Of A Dimeric Mitomycin
标题:7-N,7'-N'-(1″,2″-Dithianyl-3″,6″-Dimethylenyl)Bismitomycin C: Synthesis And Nucleophilic Activation Of A Dimeric Mitomycin
摘要:能够修饰互补 Dna 链的二聚烷基化剂引起了人们的极大兴趣.我们制备了新型二聚丝裂霉素--7-N,7â²-Nâ²-(1â³,2â³-二噻烷基-3â³,6â³-二亚甲基)双丝裂霉素 C (9),其中丝裂霉素由一个二噻烷单元桥接.二聚体 9 与临床测试的无环二硫化物 Kw-2149 (3) 和 Bms-181174 (4) 一样,都是在亲核和还原条件下激活的.9 在亲核剂介导下连续发生二硫裂解转化,预计会产生硫醇物种,从而使两种丝裂霉素系统易受亲核攻击,并允许 Dna 链间交联的形成.二噻烷连接体位于两种丝裂霉素之间,具有战略意义,使 9 号与 3 号和 4 号区别开来.这种环状二硫化物的亲核活化使得两种活化的丝裂霉素能够彼此保持连接.我们报告了 9 的合成过程,并表明与参考化合物 7-N,7â²-Nâ²-(环己基-反式-1â³,4â³-二甲苯基)双丝裂霉素 C(27)相比,亲核剂 Et3P 能显著提高 9 的活化和消耗.我们还进一步证明,与二聚参比化合物 27 和 7-N,7-Nâ²-(2â³,5â³-二羟基-1â³,6â³-己二基)霉素 C(28)或单体丝裂霉素 1 和 3 相比,当向含有 Ecori 线性化 Pbr322 Dna 的溶液中加入 Et3P 时,9 能提供更高水平的 Dna 链间交联.
Doi:10.1039/b414806A

专利信息

专利号:US-11485823-B2
优先权日:2017-06-29
标 题:Polymer for delivery of biologically active materials
发明人：YANG YI-YAN; YANG CHUAN; CHENG WEI; LEE ASHLYNN
权利人:AGENCY SCIENCE TECH & RES
摘要:The present invention mainly relates to a polymer for delivery of biologically active materials, a complex and a method of synthesis thereof. The polymer comprises a poly(ethylene imine) and at least one monomer, each monomer comprising a modified sugar moiety, preferably galactose, comprising a sulphur atom or a nitrogen atom and a chemical moiety comprising a terminal epoxide for linking the polyethylene imine to the monomer, wherein the sulphur atom or the nitrogen atom links the modified sugar moiety to the chemical moiety. The biologically active material is preferably a gene, siRNA, mRNA or plasmid DNA. Further disclosed is the medical use of said complex in treating a disease caused by a genetic disorder, for example cancer.

专利号:US-7465838-B2
优先权日:2002-10-01
标题:Chiral diols, their manufacture and ligands and catalysts derived therefrom
发明人：BERENS ULRICH
权利人:CIBA SPECIALTY CHEMICAL CORP
摘要:The present invention relates to a method for the preparation of C 2 -symmetric 1,4-diols of the formula IVA or IVB, wherein ring A, R 1 and R 2 have the meanings given in the specification, that makes use of the metallation of pure enantiomers of α-(aryl or heteroaryl)-α-substituted alkanol compounds or the use of said alkanol compounds in the preparation of said mmetric 1,4-diols; novel C 2 -symmetric 1,4-diols in enantiomerically pure form; and methods of use or their use in the synthesis of chiral ligands which find use to produce catalysts for a variety of asymmetric transformations such as hydrogenations.

专利号:US-10399925-B2
优先权日:2014-05-16
标题:Beta-hydroxylated tertiary diamines, a process for their synthesis and their use for eliminating acid compounds a gaseous effluent
发明人：GRANDJEAN JULIEN; DELFORT BRUNO; LE PENNEC DOMINIQUE; HUARD THIERRY; WENDER AURELIE; NIGON ARMELLE
权利人:IFP ENERGIES NOW
摘要:The invention relates to novel nitrogen compounds belonging to the family of tertiary diamines of general formula (I) below, wherein R is an alkanediyl radical —(CH 2 )n- with n=2, 3, 4, 5 or 6. n nThe compound according to the invention is for example N,N,N′,N′-(tetramethyl)-1,6-diamino-2,5-hexanediol or N,N,N′,N′-(tetramethyl)-1,8-diamino-2,7-octanediol. The invention also relates to the method for preparing them and to their use for removing acid compounds contained in a gaseous effluent.

专利号:US-6706209-B1
优先权日:1999-08-27
标题:Stabilized monomer composition
发明人：SCHARF JAKOB; RAU HARTMUT; GOETZEN FRIEDRICH
权利人:ROEHM GMBH
摘要:A stabilized monomer composition containing at least one ethylenically unsaturated monomer and a combination of N,N-diethylhydroxylamine an N-nitroso-N-phenylhydroxylamine or its salt in a weight ratio of from 1:1 to 10:1 permits the synthesis of 2-hydroxyalkyl (meth)acrylates in particularly high yields and remains stable during prolonged storage.

专利号:US-11773002-B2
优先权日:2020-05-19
标题:Method to prepare three-dimensional transparent glass via polymer plasticity
发明人：XIE TAO; ZHENG NING; XU YANG; ZHAO QIAN
权利人:ZJU HANGZHOU GLOBAL SCIENTIFIC AND TECH INNOVATION CENTER
摘要:The present disclosure provides a method to fabricate three-dimensional transparent glass utilizing polymer plasticity, including the following steps. In step 1, synthesize polymer-glass powder composite containing dynamic chemical bonds, the bond exchange catalyst is added during the synthesis process, and then cure to obtain a two-dimensional sheet shape I, the bond exchange catalyst is used to activate a dynamic chemical bond in step 2. In step 2, shape the two-dimensional sheet shape I obtained in step 1 into a complex three-dimensional shape II under the conditions of the effect of an external force and the activable dynamic chemical bond. In step 3, pyrolyze the composite precursor at high temperature to obtain transparent glass with complex three-dimensional shape II. The present disclosure provides a method in shaping the transparent glass with complex geometries by unique polymer plasticity in lower temperature.