CAS: 520-26-3; (S)-5-Hydroxy-2-(3-Hydroxy-4-Methoxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-Trihydroxy-6-Methyltetrahydro-2H-Pyran-2-yl)Oxy)Methyl)Tetrahydro-2H-Pyran-2-yl)Oxy)Chroman-4-One

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CAS号161713-86-6 alpha-Glucosyl ... | CAS号64-17-5 乙醇 | CAS号50376-44-8 3,2',6'-trihydr... | CAS号64726-90-5 hesperetin 7-O-... | CAS号537-73-5 异阿魏酸 | CAS号520-27-4 地奥司明 | CAS号520-33-2 橙皮素 | CAS号1356391-89-3 4-methylumbelli... | CAS号26184-96-3 6-O-(6-deoxy-al... | CAS号187539-57-7 芸香糖乙苷

4G-α-D-Glucopyranosyl Hesperidin置于small Intestine Homogenate Of Rat体系中,化学反应 1.0H,反应生成 橙皮甙
参考文献:Bioavailability Of Glucosyl Hesperidin In Rats
标题:Bioavailability Of Glucosyl Hesperidin In Rats
摘要:葡萄糖苷橙皮苷(g-橙皮苷)是一种水溶性的橙皮苷衍生物.我们比较了g-橙皮苷与橙皮苷在大鼠中的吸收和代谢情况.在给大鼠口服g-橙皮苷或橙皮苷后,通过β-葡萄糖醛酸酶水解的血清中检测到了橙皮素,但在未水解的血清中未检测到.使用g-橙皮苷处理的大鼠血清中橙皮素的出现速度比使用橙皮苷处理的大鼠更快.使用g-橙皮苷处理的大鼠血清中橙皮素的浓度-时间曲线下面积大约是使用橙皮苷处理的大鼠的3.7倍.在两个给药组的尿液中均检测到了橙皮素及其葡萄糖醛酸盐.g-橙皮苷处理的大鼠代谢物的尿液排泄量高于橙皮苷处理的大鼠.这些结果表明g-橙皮苷与橙皮苷具有相同的代谢特征.此外,由于其高水溶性,G-橙皮苷的吸收速度和效率高于橙皮苷.
DOI:10.1271/bbb.50657

专利信息

专利号:WO-2025081225-A1
优先权日:2023-10-17
标 题 :Synthesis of polyphenols
发明人：TURLAND CADE LACHLAN; GROLMAN DAVID; BEHRENDORFF JAMES BRUCE YARNTON HAYCOCK; MORADI SHAYLI VARASTEH; THOMSON RAINE ELIZABETH STURT
权利人:Delica Therapeutics Pty Ltd
摘要:The present disclosure relates to polyphenols, including flavonoids, flavones and cannflavins, and methods of synthesising polyphenols. The present disclosure provides methods, enzymes and compositions that may be useful in the synthesis of polyphenols.

专利号:US-7598291-B2
优先权日:2004-09-02
标题 :Methods and compositions for enhancing collagen and proteoglycan synthesis in the skin
发明人：NIMNI MARCEL; HAN BO
权利人:NIMNI MARCEL; HAN BO
摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid, a lipoic acid analogue or derivative, a bioflavonoid, a constituent of ginkgo, or an isoflavone. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.

专利号:US-2010160244-A1
优先权日:2004-09-02
标 题 :Methods and compositions for enhancing collagen, proteoglycan, and glutathione synthesis in the skin
发明人：NIMNI MARCEL; HAN BO
权利人:NIMNI MARCEL; HAN BO
摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids or hydrolyzed whey protein; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid or a lipoic acid analogue or derivative. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.

专利号:US-11766720-B2
优先权日:2021-10-07
标 题 :Method of making silver nanoparticles
发明人：OLADEPO SULAYMAN ADEYEMI
权利人:UNIV KING FAHD PET & MINERALS
摘要:A method of synthesis of silver nanoparticles (AgNP's) using an orange peel extract is described. The method includes preparing an orange peel extract by cutting a portion of an orange peel into smaller pieces and washing the cut orange peel pieces with de-ionized water to form a washed orange peel. The method further includes boiling the washed orange peel in de-ionized water for at least 3 minutes to form an extract solution and filtering the extract solution from the orange peel to obtain the orange peel extract. The method further includes forming a synthesis mixture of at least one silver salt and the orange peel extract and reacting the silver salt and the orange peel extract to form the silver nanoparticles within 1 minute. The silver nanoparticles find application in detection of mercury ions in an aqueous solution.

专利号:US-2006115880-A1
优先权日:2002-12-03
标 题 :Enzymatic production of acyl flavonoid derivatives
发明人：GHOUL MOHAMED; ENGASSER JEAN-MARC; MOUSSOU PHILIPPE; PAULY GILLES; ARDHAOUI MELIKA; FALCIMAIGNE AUDE
权利人:COGNIS FRANCE SA
摘要:Disclosed is a method for enzymatic synthesis of esters of flavonoid and flavonoid derivatives, according to which a reaction medium containing an organic solvent, a glycosylated flavonoid or aglycon flavonoid, an acyl group donor, and an enzymatic catalyst is produced, b) additional quantities of flavonoid and/or acyl donor are optionally added during the reaction, and c) the obtained esters are separated from the enzymatic particles and the solvent. The inventive method is characterized by maintaining the concentration of water and/or alcohol which are formed during the reaction to below 150 mM. Advantageously, the molar ratio of flavonoid to acyl donor in the reaction medium is maintained in the range from 0.01 to 20.00 during the reaction.

专利号:US-2024026314-A1
优先权日:2020-11-25
标题 :Polypeptides for use in the synthesis of bioactive phenolic compounds
发明人：ROTHSTEIN STEVEN; AKHTAR TARIQ; CASARETTO JOSE; PERRIN COLBY; VAN GELDER KRISTEN
权利人:ROTHSTEIN STEVEN; AKHTAR TARIQ; CASARETTO JOSE; PERRIN COLBY; VAN GELDER KRISTEN
摘要:Described herein is a polypeptide encoding a prenyltransferase for prenylating a polyphenol and a polypeptide encoding an O-methyltransferase for methylating a polyphenol. For example, the polypeptide comprises or consists of the sequence of SEQ ID NO: 1, 2, 3, 4, 5, and/or 6, and/or a polypeptide listed in Table 1, and/or SEQ ID NO: 7-30, or a variant thereof having at least 80% sequence identity to SEQ ID NO: 1, 2, 3, 4, 5, and/or 6, and/or the polypeptide listed in Table 1, and/or SEQ ID NO: 7-30, or a fragment of the polypeptide or the variant thereof.