专利号:US-9428524-B2 优先权日:2010-05-25 标 题:Synthetic process for the manufacture of ecteinascidin compounds 发明人:MARTIN LÓPEZ MA JESÚS; FRANCESCH SOLLOSO ANDRÉS; CUEVAS MARCHANTE MARIA DEL CARMEN 权利人:MARTIN LÓPEZ MA JESÚS; FRANCESCH SOLLOSO ANDRÉS; CUEVAS MARCHANTE MARIA DEL CARMEN; PHARMA MAR SA 摘要:This invention relates to compounds of formula II: wherein R 1 , R 2 , Prot SH , and Prot NH are as defined, to processes for the synthesis of ecteinascidins of formula I from compounds of formula II, and to processes for the synthesis of compounds of formula II.
专利号:WO-2024112764-A1 优先权日:2022-11-21 标 题:Synthesis of pyrrolo[3,4-c]pyrroles 发明人:LUKE GEORGE P; RODRIGUEZ SONIA; OUELLET STEPHANE G; GORINS GILLES; DIKER KHALID; BEAUDENON AURÉLIE; COUSIN JONATHAN 权利人:NOVO NORDISK HEALTHCARE AG 摘要:Novel synthetic methods of making pyrrolo[3,4- c ]pyrroles, derivatives thereof, and intermediates thereto are provided. Also provided are methods using pyrrolo[3,4- c ]pyrroles in the processes for preparing bioactive compounds ( e.g. PKR Activating Compounds).
专利号:EP-4622958-A1 优先权日:2022-11-21 标 题 :Synthesis of pyrrolo[3,4-c]pyrroles
专利号:WO-2014060575-A2 优先权日:2012-10-19 标 题 :Process for the enantioselective synthesis of a tetrahydrobenzazepine compound
专利号:US-4722749-A 优先权日:1986-06-27 标题 :Pyridinesulfonamides and their use as herbicidal agents 发明人:LEE SHY-FUH 权利人:SANDOZ LTD 摘要:Substituted 2-pyridinesulfonamide 1-oxides, synthesis thereof, intermediates therefor, and the use of said compounds for the control of weeds.
专利号:US-8895696-B1 优先权日:2011-08-31 标 题 :Methods for forming peptides and peptide conjugates and peptides and peptide conjugates compositions formed thereby 发明人:SUCHECK STEVEN J; TALAN ROMMEL S; KARMAKAR PARTHA 权利人:SUCHECK STEVEN J; TALAN ROMMEL S; KARMAKAR PARTHA; UNIV TOLEDO 摘要:Methods for building peptide chains containing sulfonyl modified amines at the N-terminus, or, within amino acid side chains, of a growing peptide in a solid-phase peptide synthesis are described. Further, compositions having a sulfonyl modified amine attached to the N-terminus, or within an amino acid side chain, of a polypeptide containing three or more amino acid residues are described.
摘要:Chemla, F.; Ferreira, F.; Pérez-Luna, A., Science of Synthesis Knowledge Updates, (2012) 1, 464. 参考文献:10.1016/j.bioorg.2015.09.008 摘要:Riaz S, Khan IU, Bajda M, Ashraf M, Qurat-Ul-Ain, Shaukat A, Rehman TU, Mutahir S, Hussain S, Mustafa G, Yar M. Pyridine sulfonamide as a small key organic molecule for the potential treatment of type-II diabetes mellitus and Alzheimer's disease: In vitro studies against yeast α-glucosidase, acetylcholinesterase and butyrylcholinesterase. Bioorg Chem. 2015 Dec;63():64–71. doi: 10.1016/j.bioorg.2015.09.008.