CAS: 6418-38-8; 2,3-Difluorophenol

上下游产品

ortho-difluorobenzene 1,2,3-trifluorobenzene (2,3-difluorophenyl)boronic acid 1,1,2-Trifluoro-7-oxabicyclo[2.2.1]hept-4-ene 2,3-difluoro-4-(undecyloxy)benzene 2,3-difluoro-4-(heptyloxy)benzene 1,2-difluoro-3-hexyloxybenzene 2,3-difluoro-1-n-°Ctyloxybenzene

1,1,2-Trifluoro-7-Oxabicyclo[2.2.1]Hept-4-Ene置于lithium Diisopropyl Amide体系中,用 四氢呋喃 作为反应溶剂,化学反应 3.5H,以25%的收率获得产物2,3-二氟苯酚
参考文献:呋喃衍生物与三氟乙烯的环加成反应
标题:呋喃衍生物与三氟乙烯的环加成反应
摘要:研发了三氟乙烯与呋喃和许多衍生物的环加成反应,得到未报告的1,1,2-三氟-7-氧杂双环[2.2.1]庚-4-烯及其衍生物.使用过量的三氟乙烯,在自生压力下于200oc在不锈钢高压釜中进行反应.发现用呋喃和在2和/或5位具有甲基的衍生物进行反应.然而,在这些位置上的吸电子取代基阻止了反应.尝试使用多种碱对1,1,2-三氟-7-氧杂双环[2.2.1]庚-4-烯进行脱氟化氢反应没有反应,但是使用lda可以制备25%收率的2,3-二氟苯酚.
DOI:10.1016/s0022-1139(00)00250-5

专利信息

专利号:WO-2025149479-A1
优先权日:2024-01-12
标题:Synthesis of modified nucleoside triphosphates
发明人：KUCHELMEISTER HANNES; PFAFFENEDER TONI; MEX MARTIN; VETH SIMON; MENKE JAN-MICHAEL
权利人:ROCHE DIAGNOSTICS GMBH
摘要:The invention relates to a new diastereoselective synthesis method for highly modified nucleoside triphosphates with two conjugable groups. The method works in liquid phase with conventional laboratory equipment as used in any chemical laboratory or production. For this, a new chiral P(V) phosphorylation reagent has been designed that allows highly efficient diastereoselective synthesis under mild conditions. Overall, a highly efficient, diastereoselective, high quality, cost-effective synthetic method of modified nucleoside triphosphates has been developed.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-6689919-B1
优先权日:1999-09-22
标 题 :Catalysts for oxidative polymerization of fluorophenol, method of oxidative polymerization of fluorophenol, and poly(oxyfluorophenylene) derivative
发明人：TSUCHIDA EISHUN; OYAIZU KENICHI; KUMAKI YOSUKE; SAITO KEI
权利人:JAPAN SCIENCE & TECH CORP
摘要:The synthesis of fluoropolyarylene ether with a high degree of polymerization is enabled, by using a copper complex catalyst with an oxidation potential in the range of -1V to 2V, for the oxidative polymerization of fluorophenols that contain at least one hydrogen atom as well as a fluorine atom bonded to the carbon atoms constituting the benzene ring.

专利号:WO-2013131872-A1
优先权日:2012-03-05
标 题 :Imaging neural activity
发明人：BETTS HELEN MAY; DESMOND ANTONIA; ROBINS EDWARD GEORGE
权利人:GE HEALTHCARE LTD; UCL SCHOOL OF PHARMACY
摘要:The present invention provides a novel radiofluorinated compound for imaging voltage-gated sodium channels (VGSCs) that is more straightforward to synthesise than the known radiofluorinated phenoxyphenyl pyrazole carboxylic acid compounds. The compound of the present invention demonstrates specific uptake and retention in key tissues as well as good in vivo stability. Also provided by the present invention is a radiopharmaceutical composition comprising the radiofluorinated compound of the invention, precursor compounds and methods for the synthesis of said radiofluorinated compound, and methods for using said radiofluorinated compound.

专利号:US-5087764-A
优先权日:1988-03-10
标 题 :Process for the preparation of 2,3-difluorobenzenes
发明人：REIFFENRATH VOLKER; KRAUSE JOACHIM
权利人:MERCK PATENT GMBH
摘要:1,4-disubstituted 2,3-difluorobenzenes according to formula I are suitable as intermediates for the synthesis of liquid crystalline compounds.

专利号:US-9351974-B2
优先权日:2011-11-10
标题 :Substituted pteridinones for the treatment of cancer
发明人：JIN MEIZHONG; KADALBAJOO MRIDULA; LI AN-HU; MULVIHILL MARK J; SIU KAM W; STEINIG ARNO G; WANG JING
权利人:OSI PHARMACEUTICALS LLC
摘要:Compounds of Formula I, as shown below and defined herein: n npharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including treatment of cancers, such as tumors driven or mediated at least in part by RSK. This Abstract is not limiting of the invention.