CAS: 102229-10-7; 2-((Tert-Butyldimethylsilyl)Oxy)Ethanol

上下游产品

ethylene glycol tert-butyldimethylsilyl chloride (2-Benzyloxy-ethoxy)-tert-butyl-dimethyl-silane O-(tert-Butyldimethylsilyl)-2-(4-nitrobenzyloxy)ethanol tert-butyldimethylsiloxyacetaldehyde 2-(t-Butyldimethylsilyloxy)ethyl trifluoromethanesulfonate ethylene glycol tris[2-(tert-butyldimethylsilyloxy)ethyl] 1,3,5-benzenetricarboxylate

(2-(苄氧基)乙氧基)(叔丁基)二甲基硅烷置于5% Pd On Active Carbon Ti-Hms体系中,用 甲醇 用作溶剂,化学反应 4.0H,以71%的收率获得叔丁基二甲基羟乙氧基硅烷
参考文献:Selective Acceleration For Deprotection Of Benzyl Ethers With Ti-Hms
标题:Selective Acceleration For Deprotection Of Benzyl Ethers With Ti-Hms
摘要:Ti-Hms,A Ti-Loaded Hexagonal Mesoporous Silica,Was Found To Accelerate Deprotection Of Benzyl Ethers Under Hydrogenolytic Conditions With Palladium Catalyst. Such Acid-Sensitive Functional Groups As Silyl Ether And Acetal Moieties In The Molecule Were Little Affected By Ti-Hms,Which Possesses Lewis Acid Sites Due To Ti-Atom. (C) 1998 Elsevier Science Ltd. All Rights Reserved.
Doi:10.1016/s0040-4039(98)02145-5

专利信息

专利号:US-9938297-B2
优先权日:2014-08-04
标 题:Process for the synthesis of everolimus and intermediates thereof
发明人：RAO DHARMARAJ RAMACHANDRA; MALHOTRA GEENA; PULLELA VENKATA SRINIVAS; ACHARYA VINOD PARAMESHWARAN
权利人:CIPLA LTD; CIPIA LTD
摘要:The present invention relates to a novel process for the synthesis of everolimus of formula (I): n nand intermediates thereof.

专利号:US-6989401-B2
优先权日:2000-07-19
标题:Sulfonic acid derivatives of hydroxamic acids and their use as medicinal products
发明人：MAEDA KAZUHIRO; SONDA SHUJI; TAKEMOTO TADAHIRO; GOTO TOMOKAZU; KOBAYASHI FUJIO; KAJII MASAHIKO; KOMORITA NARUYASU; HIRAYAMA FUMIHIRO
权利人:MITSUBISHI PHARMA CORP
摘要:The present invention relates to a novel sulfonic acid derivative of hydroxamic acid or a pharmacologically acceptable salt thereof. More particularly, the present invention relates to a sulfonic acid derivative of hydroxamic acid or a pharmacologically acceptable salt thereof, which is useful as an inhibitor of lipopolysaccharides (LPS). In addition, the present invention relates to a novel intermediate compound useful for the synthesis of this sulfonic acid derivative of hydroxamic acid.

专利号:US-7799524-B2
优先权日:2002-10-03
标 题:Substrates for O6-alkylguanina-DNA alkyltransferase
发明人：KINDERMANN MAIK; JOHNSSON KAI; BIERI CHRISTOPH
权利人:ECOLE POLYTECHNIQUE FERDEALE D
摘要:The invention relates to compounds of formula 1 n nwherein R 1 -R 2 is a guanine derivative; X is oxygen or sulfur; R 3 is a heteroaromatic, unsaturated heterocyclyl or an alkynyl group with the double or triple bond connected to CH 2 ; R 4 is a linker; and L is a label, a plurality of same or different labels, a bond connecting R 4 to R 1 forming a cyclic substrate, or a further group —R 3 —CH 2 —X—R 1 -R 2 . The invention relates also to methods of manufacture of such novel AGT substrates, to intermediates useful in the synthesis of such AGT substrates, and to a method of transferring a label from such AGT substrates to O 6 -alkylguanine-DNA alkyltransferase (AGT) fusion proteins comprising proteins of interest.

专利号:US-2017217988-A1
优先权日:2014-08-04
标 题:Process for the Synthesis of Everolimus and Intermediates Thereof

专利号:EP-3166950-A1
优先权日:2014-08-04
标 题:Process for the synthesis of everolimus and intermediates thereof

专利号:WO-2016020664-A1
优先权日:2014-08-04
标 题 :Process for the synthesis of everolimus and intermediates thereof