CAS: 1192500-31-4; (1R,2S,5R)-2-Carbamoyl-7-Oxo-1,6-Diazabicyclo[3.2.1]Octan-6-Yl Hydrogen Sulfate

上下游产品

(2S,5R)-6-Hydroxy-7-Oxo-1,6-Diazabicyclo[3.2.1]Octane-2-Carboxamide
(1R,2S,5R)-7-氧代-6-(苄氧基)-1,6-二氮杂双环[3.2.1]辛烷-2-甲酰胺 (2S,5R)-6-(Benzyloxy)-7-Oxo-1,6-Diazabicyclo[3.2.1]Octane-2-Carboxamide 1192651-49-2
Methyl (2S,5R)-6-(Benzyloxy)-7-Oxo-1,6-Diazabicyclo[3.2.1]Octane-2-Carboxylate 1383814-58-1
(2S,5R)-7-氧代-6-(苯基甲氧基)-1,6-二氮杂双环[3.2.1]辛烷-2-羧酸乙酯 (2S,5R)-Ethyl 6-(Benzyloxy)-7-Oxo-1,6-Diazabicyclo[3.2.1]Octane-2-Carboxylate 1416134-63-8
(2S,5R)-Benzyl 6-(Benzyloxy)-7-Oxo-1,6-Diazabicyclo[3.2.1]Octane-2-Carboxylate 1416134-61-6

(2S,5R)-6-Hydroxy-7-Oxo-1,6-Diazabicyclo[3.2.1]octane-2-Carboxamide置于氯磺酸体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 48.0H,以97%的收率获得avibactam; 硫酸单[(1R,2S,5R)-2-(氨基羰基)-7-氧代-1,6-氮杂双环[3.2.1]辛-6-基]酯
参考文献:β内酰胺酶抑制剂阿维巴坦的合成方法
标题:β内酰胺酶抑制剂阿维巴坦的合成方法
摘要:本发明涉及一种β内酰胺酶抑制剂阿维巴坦的合成方法,属于β内酰胺酶抑制剂的制备技术领域.本发明包括以下步骤:(1)以化合物2为原料,与r1Nh2反应生成化合物3;(2)在有机溶剂中,化合物3与生物催化剂在葡萄糖或蔗糖的存在下生成化合物4;(3)化合物4和三氟乙酸酐反应生成化合物5;(4)化合物5和r2Onh2反应生成化合物6;(5)化合物6在碱性条件下水解生成化合物7;(6)化合物7和三光气反应生成化合物8;(7)在有机溶剂中,化合物8在催化剂存在下与甲酸铵反应生成化合物9,催化剂为pd/c体系;(8)化合物9与磺化剂反应生成产物1.本发明工艺稳定,收率高,操作简单安全,生产成本低.

专利信息

专利号:US-11059835-B2
优先权日:2014-08-15
标 题 :Synthesis of cephalosporin compounds
发明人：WALLER DAVID; GAZDA GREGORY; MINDEN ZACHARY; BARTON LISA; LEIGH CLIFTON
权利人:MERCK SHARP & DOHME
摘要:Provided herein is a method for the synthesis of cephalosporin antibiotic compounds comprising a palladium-catalyzed coupling reaction.

专利号:US-2023286915-A1
优先权日:2020-10-07
标 题 :Synthesis of pyrrole acid derivatives
发明人：WILKINSON ANDREW; COOPER LAN; ORR DAVID; FINLAYSON JONATHAN; BUNT ADAM; KIRKHAM JAMES; LYTH DAVID; BLADES KEVIN
权利人:INFEX THERAPEUTICS LTD
摘要:This invention relates to the synthesis of compounds that can be used to treat bacterial infections in combination with other antibacterial agents, and more specifically in combination with a class of antibacterial agents known as carbapenems. The compounds resulting from the novel methods of the present invention are enzyme inhibitors and more particularly are metallo-β-lactamase inhibitors.

专利号:US-2025009786-A1
优先权日:2021-09-30
标 题 :Automated synthesis of polymeric dual drugs
发明人：MATRAY TRACY; VANBRUNT MICHAEL; MCCUTCHEON JOHN MICHAEL
权利人:SONY GROUP CORP
摘要:Compounds useful as biologically active compounds with or without fluorescent or colored dyes are disclosed. In some embodiments, the compounds have the following structure (I): (I) or a stereoisomer, tautomer or salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, L1, L2, L3, L4, L5, L6, L7, L8, L9, L10, L11, M1, M2, M3, l, m, n, p, and q are as defined herein. Additional compound, methods of preparation, pharmaceutical compositions, and methods of treatment related to compounds of Structure (I) are also provided.

专利号:US-10941161-B2
优先权日:2014-08-15
标 题:Intermediates in the synthesis of cephalosporin compounds
发明人：MOSHOS KRISTOS ADRIAN; JURKAUSKAS VALDAS; FOGLIATO GIOVANNI; SCANU MANUEL; HWANG YOU SEOK
权利人:MERCK SHARP & DOHME
摘要:Described herein are crystalline forms of a compound of formula (III′), including toluene solvates of TATD-CLE, as well as processes for the preparation thereof and use thereof in the preparation of cephalosporin compounds such as ceftolozane.

专利号:US-11542279-B2
优先权日:2016-06-06
标 题:Solid forms of ceftolozane and processes for preparing
发明人：MALONEY KEVIN MATTHEW; SIROTA ERIC M; VARSOLONA RICHARD J; GAUTHIER JR DONALD R; REN HONG
权利人:MERCK SHARP & DOHME; MERCK SHARP & DOHME LLC
摘要:The instant invention is related to a novel solid form of ceftolozane sulfate (the DMAc solvate of ceftolozane sulfate (Form 3)), compositions comprising ceftolozane sulfate DMAc solvate (Form 3), synthesis of Form 3 and an improved crystallization process using Form 3 to prepare ceftolozane sulfate Form 2. Novel compositions also include ceftolozane sulfate solid Form 3 and/or other crystalline and amorphous solid forms of ceftolozane.

专利号:WO-2025027521-A1
优先权日:2023-08-01
标题 :An improved process for the preparation of avibactam and intermediate thereof
发明人：DHAVARIA SANDEEP; HANDA VISHAL; SHARMA SUNEEL KUMAR; MEHTA ANSHU KUMAR; SINGH ADITYA NARAYAN; ABUL AZIM; GUPTA NITIN; SINGH GOVIND; CABRI WALTER
权利人:FRESENIUS KABI ONCOLOGY LTD
摘要:The present invention relates to an improved process for the preparation of Avibactam or a pharmaceutically acceptable salt thereof, particularly the present invention relates to process for the preparation of a bridged ester intermediate of Formula I, wherein R1 is a hydroxy protecting group which is a key intermediate for Avibactam or a pharmaceutically acceptable salt thereof. The present invention also relates to the crystalline form of intermediates used for the synthesis of Avibactam or a pharmaceutically acceptable salt thereof. The invention also provides improved processes for the preparation of Avibactam or a pharmaceutically acceptable salt, using the bridged ester compound of formula I prepared by the process of the present invention.