专利号:US-9920084-B2 优先权日:2011-08-23 标题 :Ionic tags for synthesis of oligoribonucleotides 发明人:DAMHA MASAD J; HASSLER MATTHEW; CHAN TAK-HANG; NANDYALA MALLIKARJUNA REDDY; DONGA ROBERT ALEXANDER 权利人:DAMHA MASAD J; HASSLER MATTHEW; CHAN TAK HANG; NANDYALA MALLIKARJUNA REDDY; DONGA ROBERT ALEXANDER; THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIV; HONG KONG POLYTECHNIC UNIV 摘要:The invention relates to the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. In another aspect, the invention relates to compounds of formula (II) processes for making these compounds, and the use thereof in the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. The invention also relates to methods of synthesis of oligomers, including but not limited to oligopeptides, oligosaccharides and oligonucleotides, particularly oligoribonucleotides and also oligodeoxyribonucleotides, in solution systems, and ionic tag linkers for use in methods provided herein.
专利号:WO-2025086012-A1 优先权日:2023-10-27 标题:Catalyst for the synthesis of methanol from methane and carbon dioxide 发明人:LI CHAO-JUN; SU HUI; HAN JINGTAN 权利人:THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIV 摘要:There is provided a photocatalyst for the direct synthesis of methanol from methane and carbon dioxide. The photocatalyst comprises an AuPd alloy nanoparticles dispersed on a support comprising GaN, InN, AlN, BN, TlN, GaP, InP or a combination thereof. The AuPd alloy nanoparticles are uniformly dispersed on the support such that at least 90% of the AuPd alloy nanoparticles are positioned at a distance of from 1 nm to 15 nm from other AuPd alloy nanoparticles. There is also provided a method of synthesizing methanol from methane and carbon dioxide with a photocatalyst comprising a transition metal dispersed on a support comprising GaN, InN, AlN, BN, TlN, GaP, InP or a combination thereof.
专利号:US-11623872-B2 优先权日:2019-06-13 标 题 :Device and method for synthesis of gallium-containing garnet-structured scintillator poly crystalline material 发明人:DING YUCHONG 权利人:CHINA ELECTRONICS TECH GROUP CORPORATION NO 26 RESEARCH INSTITUTE 摘要:Provided are a device and a method for synthesis of a gallium-containing garnet-structured scintillator polycrystalline material. The synthesis device includes a polycrystalline material synthesis chamber (7) made of a thermal insulation material (1); a crucible (3) arranged at the center of the bottom of the polycrystalline material synthesis chamber; an induction coil (2) annularly arranged outside the polycrystalline material synthesis chamber at a position with a height corresponding to that of the crucible; an arc heating device (4) arranged on a central axis of the induction coil in the polycrystalline material synthesis chamber, so as to heat and melt raw materials at the center of the crucible by means of the high temperature generated by arc discharge; the induction coil is connected to a RF induction power supply.
专利号:WO-2025125181-A1 优先权日:2023-12-14 标题:Green hydrogen, synthesis gas with a reduced nitrogen content, and flue gas for the synthesis of ammonia and urea 发明人:GORVAL EVGENI 权利人:THYSSENKRUPP UHDE GMBH; THYSSENKRUPP AG 摘要:The invention relates to the synthesis of urea from ammonia and carbon dioxide, wherein the hydrogen required for ammonia synthesis is obtained both by steam reforming of feed natural gas (grey hydrogen) and by electrolysis of water using electricity from renewable energy sources (green hydrogen). As the proportion of green hydrogen increases, the amount of carbon dioxide formed in the synthesis gas during steam reforming is no longer sufficient for the synthesis of urea. Therefore, flue gas, which is formed during the combustion of a fuel gas composed of fuel natural gas and combustion air and which also contains carbon dioxide, is additionally used. The oxygen formed during the electrolysis of water is introduced into the flue gas, and the modified flue gas is fed to a secondary reformer; and/or the fuel natural gas is combusted together with combustion air and the oxygen formed during electrolysis. Excess nitrogen is preferably separated from the synthesis gas before it is used for the synthesis of ammonia.
专利号:US-11643387-B2 优先权日:2019-07-18 标题 :Process for the synthesis of urea 发明人:MARRONE LEONARDO; BERTINI PAOLO 权利人:CASALE SA 摘要:A process for synthesis of urea from ammonia and carbon dioxide comprising the synthesis of urea in parallel in a first urea reactor ( 1 ) at a first urea synthesis pressure and in a second urea reactor ( 2 ) at a second and lower urea synthesis pressure; a stripping step of the reaction effluent of the first reactor, which is performed in a stripper ( 4 ) operating at a stripping pressure lower than the first urea synthesis pressure; the reaction effluent ( 21 ) of the second reactor ( 2 ) and the stripper liquid effluent ( 11 ) are sent to a recovery section ( 13 ) where a carbamate-containing recycle solution ( 17 ) is produced, and said recycle solution ( 17 ) is sent partly to said first reactor and partly to said second reactor.
专利号:US-9884885-B2 优先权日:2009-05-18 标题:Synthesis of labile base protected-modified deoxy and modified ribo nucleosides, corresponding phosphoramidites and supports and their use in high purity oligonucleotide synthesis 发明人:SRIVASTAVA SURESH C; SRIVASTAVA NAVEEN P 权利人:SRIVASTAVA SURESH C; SRIVASTAVA NAVEEN P; CHEMGENES CORP 摘要:This invention relates to novel method of synthesis of RNA utilizing N-2-acetyl protected guanine as nucleoside base, nucleosides, succinates, phosphoramidites, corresponding solid supports that are suitable for oligo deoxy nucleosides and RNA oligonucleotide synthesis. Our discovery using N-acetyl protected guanine as nucleoside base protecting group, which is significantly faster base labile protecting group, yet significantly more stable than commonly utilized-2-isobutyryl guanosine is a novel approach to obtain highest purity oligonucleotides. This approach is designed to lead to very high purity and very clean oligonucleotide, after efficient removal of the protecting groups, including acetyl group from guanine and to produce high purity therapeutic grade DNA oligonucleotides, RNA oligonucleotides, diagnostic DNA, diagnostic RNA for microarray platform. The deprotection of acetyl protecting groups of the natural deoxy and ribonucleosides occurs under substantially reduced time in contact with mild deprotection conditions such as mild bases, secondary amines for removal of such groups under such conditions would allows synthesis of various DNA and RNA of highest purity for diagnostics and therapeutic application. This approach is designed to lead to high purity large scale therapeutic grade oligonucleotide chimeras which consist of fluoro sugar modification in conjunction with deoxy nucleosides, ribonucleosides, modified base and modified sugar nucleosides. This approach is further designed to use acetyl guanine protecting group when other bases are sensitive nucleoside, and for use in oligo peptide synthesis and for support bound oligo nucleotides.
参考文献:10.1510/icvts.2009.228270 摘要:Badreldin AM, Albert AA, Ismail MM, Heldwein M, Doerr F, Bossert T, Lichtenberg A, Hekmat K. Gaseous emboli during off-pump surgery with T-graft technique, two different mechanisms. Interact Cardiovasc Thorac Surg. 2010 May;10(5):766–9. doi: 10.1510/icvts.2009.228270. 参考文献:10.1242/jeb.039842 摘要:McCue MD, Sivan O, McWilliams SR, Pinshow B. Tracking the oxidative kinetics of carbohydrates, amino acids and fatty acids in the house sparrow using exhaled 13CO2. J Exp Biol. 2010 Mar 01;213(5):782–9. doi: 10.1242/jeb.039842. 参考文献:10.1099/ijs.0.021782-0 摘要:Bräuer SL, Cadillo-Quiroz H, Ward RJ, Yavitt JB, Zinder SH. Methanoregula boonei gen. nov., sp. nov., an acidiphilic methanogen isolated from an acidic peat bog. Int J Syst Evol Microbiol. 2011 Jan;61(Pt 1):45–52. doi: 10.1099/ijs.0.021782-0. 参考文献:10.1007/s00216-010-3487-0 摘要:Tomicic C, Berode M. Sensitive headspace gas chromatography analysis of free and conjugated 1-methoxy-2-propanol in urine. Analytical and Bioanalytical Chemistry. 2010 Feb 13;396(7):2709–14. doi: 10.1007/s00216-010-3487-0. 参考文献:10.1007/s00442-010-1572-x 摘要:Wang X, Taub DR. Interactive effects of elevated carbon dioxide and environmental stresses on root mass fraction in plants: a meta-analytical synthesis using pairwise techniques. Oecologia. 2010 May;163(1):1–11. doi: 10.1007/s00442-010-1572-x.